Discovery of 2-pyridineformamide thiosemicarbazones as potent antiausterity agents

Bhushan Shakya, Paras Nath Yadav, Jun Ya Ueda, Suresh Awale*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Series of 2-pyridineformamide thiosemicarbazones were synthesized. Their preferential cytotoxicity in nutrient deprived medium (NDM) was evaluated using PANC-1 human pancreatic cancer cells by employing an antiausterity strategy. 2-Pyridineformamide thiosemicarbazones induced apoptosis and exhibited preferential cytotoxic activity toward PANC-1 cells in NDM, with potencies in the submicromolar range. These compounds are potential candidates for the development of therapeutics against pancreatic cancer.

Original languageEnglish
Pages (from-to)458-461
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume24
Issue number2
DOIs
StatePublished - 2014/01/15

Keywords

  • 2-Pyridineformamide thiosemicarbazones
  • Antiausterity agents
  • Apoptosis
  • Nutrition starvation
  • Pancreatic cancer

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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