Discovery of 2-pyridineformamide thiosemicarbazones as potent antiausterity agents

Bhushan Shakya; Paras Nath Yadav; Jun Ya Ueda; Suresh Awale

doi:10.1016/j.bmcl.2013.12.044

Discovery of 2-pyridineformamide thiosemicarbazones as potent antiausterity agents

Bhushan Shakya, Paras Nath Yadav, Jun Ya Ueda, Suresh Awale^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Series of 2-pyridineformamide thiosemicarbazones were synthesized. Their preferential cytotoxicity in nutrient deprived medium (NDM) was evaluated using PANC-1 human pancreatic cancer cells by employing an antiausterity strategy. 2-Pyridineformamide thiosemicarbazones induced apoptosis and exhibited preferential cytotoxic activity toward PANC-1 cells in NDM, with potencies in the submicromolar range. These compounds are potential candidates for the development of therapeutics against pancreatic cancer.

Original language	English
Pages (from-to)	458-461
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/j.bmcl.2013.12.044
State	Published - 2014/01/15

Keywords

2-Pyridineformamide thiosemicarbazones
Antiausterity agents
Apoptosis
Nutrition starvation
Pancreatic cancer

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2013.12.044

Cite this

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title = "Discovery of 2-pyridineformamide thiosemicarbazones as potent antiausterity agents",

abstract = "Series of 2-pyridineformamide thiosemicarbazones were synthesized. Their preferential cytotoxicity in nutrient deprived medium (NDM) was evaluated using PANC-1 human pancreatic cancer cells by employing an antiausterity strategy. 2-Pyridineformamide thiosemicarbazones induced apoptosis and exhibited preferential cytotoxic activity toward PANC-1 cells in NDM, with potencies in the submicromolar range. These compounds are potential candidates for the development of therapeutics against pancreatic cancer.",

keywords = "2-Pyridineformamide thiosemicarbazones, Antiausterity agents, Apoptosis, Nutrition starvation, Pancreatic cancer",

author = "Bhushan Shakya and Yadav, {Paras Nath} and Ueda, {Jun Ya} and Suresh Awale",

note = "Funding Information: This work was supported by a Grant from Toyama Support Center for Young Principal Investigators in Advanced Life Sciences, Japan , and a Grant in Aid for Scientific Research (No. 24510314 ) from the Japan Society for the Promotion of Science (JSPS) to S.A., and the University Grants Commission of the Government of Nepal to B.S. We thank Dr. Rajendra Kumar Shakya, Wayne State University for the NMR data acquisition. ",

year = "2014",

month = jan,

day = "15",

doi = "10.1016/j.bmcl.2013.12.044",

language = "英語",

volume = "24",

pages = "458--461",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

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T1 - Discovery of 2-pyridineformamide thiosemicarbazones as potent antiausterity agents

AU - Shakya, Bhushan

AU - Yadav, Paras Nath

AU - Ueda, Jun Ya

AU - Awale, Suresh

N1 - Funding Information: This work was supported by a Grant from Toyama Support Center for Young Principal Investigators in Advanced Life Sciences, Japan , and a Grant in Aid for Scientific Research (No. 24510314 ) from the Japan Society for the Promotion of Science (JSPS) to S.A., and the University Grants Commission of the Government of Nepal to B.S. We thank Dr. Rajendra Kumar Shakya, Wayne State University for the NMR data acquisition.

PY - 2014/1/15

Y1 - 2014/1/15

N2 - Series of 2-pyridineformamide thiosemicarbazones were synthesized. Their preferential cytotoxicity in nutrient deprived medium (NDM) was evaluated using PANC-1 human pancreatic cancer cells by employing an antiausterity strategy. 2-Pyridineformamide thiosemicarbazones induced apoptosis and exhibited preferential cytotoxic activity toward PANC-1 cells in NDM, with potencies in the submicromolar range. These compounds are potential candidates for the development of therapeutics against pancreatic cancer.

AB - Series of 2-pyridineformamide thiosemicarbazones were synthesized. Their preferential cytotoxicity in nutrient deprived medium (NDM) was evaluated using PANC-1 human pancreatic cancer cells by employing an antiausterity strategy. 2-Pyridineformamide thiosemicarbazones induced apoptosis and exhibited preferential cytotoxic activity toward PANC-1 cells in NDM, with potencies in the submicromolar range. These compounds are potential candidates for the development of therapeutics against pancreatic cancer.

KW - 2-Pyridineformamide thiosemicarbazones

KW - Antiausterity agents

KW - Apoptosis

KW - Nutrition starvation

KW - Pancreatic cancer

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U2 - 10.1016/j.bmcl.2013.12.044

DO - 10.1016/j.bmcl.2013.12.044

M3 - 学術論文

C2 - 24380769

AN - SCOPUS:84891881616

SN - 0960-894X

VL - 24

SP - 458

EP - 461

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

Discovery of 2-pyridineformamide thiosemicarbazones as potent antiausterity agents

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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