Differential effects of DNA tumor virus nuclear oncogene products on adipocyte differentiation

Kazuyuki Tobe; Masato Kasuga; Hidero Kitasato; Fumimaro Takaku; Toshiya Takano; Kaoru Segawa

doi:10.1016/0014-5793(87)80175-8

Differential effects of DNA tumor virus nuclear oncogene products on adipocyte differentiation

Kazuyuki Tobe, Masato Kasuga, Hidero Kitasato, Fumimaro Takaku, Toshiya Takano, Kaoru Segawa^*

^*この論文の責任著者

内科学（第一）講座

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

15 被引用数 (Scopus)

抄録

We have introduced SV40 and polyoma large T antigen- and adenovirus-type 12 E1A genes into mouse 3T3-L1 preadipocyte cells to study the ability of various nuclear oncogene products to modulate cell differentiation. Clones expressing E1A products could differentiate into adipocytes faster than the control in spite of the absence of adipogenic inducers, as measured by the appearance of lipid droplets microscopically and by staining accumulated triglycerides with oil red O. However, clones expressing SV40 and polyoma large T antigens could not differentiate even if they were exposed to the inducers.

本文言語	英語
ページ（範囲）	345-349
ページ数	5
ジャーナル	FEBS Letters
巻	215
号	2
DOI	https://doi.org/10.1016/0014-5793(87)80175-8
出版ステータス	出版済み - 1987/05/11

ASJC Scopus 主題領域

生物理学
構造生物学
生化学
分子生物学
遺伝学
細胞生物学

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10.1016/0014-5793(87)80175-8

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title = "Differential effects of DNA tumor virus nuclear oncogene products on adipocyte differentiation",

abstract = "We have introduced SV40 and polyoma large T antigen- and adenovirus-type 12 E1A genes into mouse 3T3-L1 preadipocyte cells to study the ability of various nuclear oncogene products to modulate cell differentiation. Clones expressing E1A products could differentiate into adipocytes faster than the control in spite of the absence of adipogenic inducers, as measured by the appearance of lipid droplets microscopically and by staining accumulated triglycerides with oil red O. However, clones expressing SV40 and polyoma large T antigens could not differentiate even if they were exposed to the inducers.",

keywords = "Adipogenic differentiation, DNA tumor virus, Nuclear oncogene",

author = "Kazuyuki Tobe and Masato Kasuga and Hidero Kitasato and Fumimaro Takaku and Toshiya Takano and Kaoru Segawa",

year = "1987",

month = may,

day = "11",

doi = "10.1016/0014-5793(87)80175-8",

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T1 - Differential effects of DNA tumor virus nuclear oncogene products on adipocyte differentiation

AU - Tobe, Kazuyuki

AU - Kasuga, Masato

AU - Kitasato, Hidero

AU - Takaku, Fumimaro

AU - Takano, Toshiya

AU - Segawa, Kaoru

PY - 1987/5/11

Y1 - 1987/5/11

N2 - We have introduced SV40 and polyoma large T antigen- and adenovirus-type 12 E1A genes into mouse 3T3-L1 preadipocyte cells to study the ability of various nuclear oncogene products to modulate cell differentiation. Clones expressing E1A products could differentiate into adipocytes faster than the control in spite of the absence of adipogenic inducers, as measured by the appearance of lipid droplets microscopically and by staining accumulated triglycerides with oil red O. However, clones expressing SV40 and polyoma large T antigens could not differentiate even if they were exposed to the inducers.

AB - We have introduced SV40 and polyoma large T antigen- and adenovirus-type 12 E1A genes into mouse 3T3-L1 preadipocyte cells to study the ability of various nuclear oncogene products to modulate cell differentiation. Clones expressing E1A products could differentiate into adipocytes faster than the control in spite of the absence of adipogenic inducers, as measured by the appearance of lipid droplets microscopically and by staining accumulated triglycerides with oil red O. However, clones expressing SV40 and polyoma large T antigens could not differentiate even if they were exposed to the inducers.

KW - Adipogenic differentiation

KW - DNA tumor virus

KW - Nuclear oncogene

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AN - SCOPUS:0023278961

SN - 0014-5793

VL - 215

SP - 345

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JO - FEBS Letters

JF - FEBS Letters

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ER -

Differential effects of DNA tumor virus nuclear oncogene products on adipocyte differentiation

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