TY - JOUR
T1 - Depressed functions of T cells and the presence of suppressor macrophages in patients with sarcoidosis
AU - Muraguchi, Atsushi
AU - Tachibana, Teruo
AU - Miki, Yoshitsugu
AU - Kuritani, Taro
AU - Kishi, Hiroyuki
AU - Kishimoto, Susumu
AU - Yamamura, Yuichi
AU - Kishimoto, Tadamitsu
PY - 1982/5
Y1 - 1982/5
N2 - T-cell functions of patients with sarcoidosis were studied by employing PWM-induced immunoglobulin (Ig) synthesis and PHA-induced T-cell colony formation. Con A-induced suppressor function as well as helper function in PWM-induced Ig production was markedly depressed in T cells from patients with sarcoidosis. PHA-induced T colony formation was also found to be markedly depressed in patients with sarcoidosis. However, the depressed colony formation was recovered by depletion of macrophages or by addition of indomethacin. The addition of the soluble factors derived from patients' macrophages suppressed the colony formation of T cells from healthy adult volunteers. Taken together, the results suggest that the presence of suppressor macrophages may induce the depressed state of several T-cell functions in patients with sarcoidosis.
AB - T-cell functions of patients with sarcoidosis were studied by employing PWM-induced immunoglobulin (Ig) synthesis and PHA-induced T-cell colony formation. Con A-induced suppressor function as well as helper function in PWM-induced Ig production was markedly depressed in T cells from patients with sarcoidosis. PHA-induced T colony formation was also found to be markedly depressed in patients with sarcoidosis. However, the depressed colony formation was recovered by depletion of macrophages or by addition of indomethacin. The addition of the soluble factors derived from patients' macrophages suppressed the colony formation of T cells from healthy adult volunteers. Taken together, the results suggest that the presence of suppressor macrophages may induce the depressed state of several T-cell functions in patients with sarcoidosis.
UR - http://www.scopus.com/inward/record.url?scp=0019995806&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(82)90107-6
DO - 10.1016/0090-1229(82)90107-6
M3 - 学術論文
C2 - 6213337
AN - SCOPUS:0019995806
SN - 0090-1229
VL - 23
SP - 189
EP - 201
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 2
ER -