Depressed functions of T cells and the presence of suppressor macrophages in patients with sarcoidosis

Atsushi Muraguchi; Teruo Tachibana; Yoshitsugu Miki; Taro Kuritani; Hiroyuki Kishi; Susumu Kishimoto; Yuichi Yamamura; Tadamitsu Kishimoto

doi:10.1016/0090-1229(82)90107-6

Depressed functions of T cells and the presence of suppressor macrophages in patients with sarcoidosis

Atsushi Muraguchi^*, Teruo Tachibana, Yoshitsugu Miki, Taro Kuritani, Hiroyuki Kishi, Susumu Kishimoto, Yuichi Yamamura, Tadamitsu Kishimoto

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

T-cell functions of patients with sarcoidosis were studied by employing PWM-induced immunoglobulin (Ig) synthesis and PHA-induced T-cell colony formation. Con A-induced suppressor function as well as helper function in PWM-induced Ig production was markedly depressed in T cells from patients with sarcoidosis. PHA-induced T colony formation was also found to be markedly depressed in patients with sarcoidosis. However, the depressed colony formation was recovered by depletion of macrophages or by addition of indomethacin. The addition of the soluble factors derived from patients' macrophages suppressed the colony formation of T cells from healthy adult volunteers. Taken together, the results suggest that the presence of suppressor macrophages may induce the depressed state of several T-cell functions in patients with sarcoidosis.

Original language	English
Pages (from-to)	189-201
Number of pages	13
Journal	Clinical Immunology and Immunopathology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/0090-1229(82)90107-6
State	Published - 1982/05

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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title = "Depressed functions of T cells and the presence of suppressor macrophages in patients with sarcoidosis",

abstract = "T-cell functions of patients with sarcoidosis were studied by employing PWM-induced immunoglobulin (Ig) synthesis and PHA-induced T-cell colony formation. Con A-induced suppressor function as well as helper function in PWM-induced Ig production was markedly depressed in T cells from patients with sarcoidosis. PHA-induced T colony formation was also found to be markedly depressed in patients with sarcoidosis. However, the depressed colony formation was recovered by depletion of macrophages or by addition of indomethacin. The addition of the soluble factors derived from patients' macrophages suppressed the colony formation of T cells from healthy adult volunteers. Taken together, the results suggest that the presence of suppressor macrophages may induce the depressed state of several T-cell functions in patients with sarcoidosis.",

author = "Atsushi Muraguchi and Teruo Tachibana and Yoshitsugu Miki and Taro Kuritani and Hiroyuki Kishi and Susumu Kishimoto and Yuichi Yamamura and Tadamitsu Kishimoto",

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T1 - Depressed functions of T cells and the presence of suppressor macrophages in patients with sarcoidosis

AU - Muraguchi, Atsushi

AU - Tachibana, Teruo

AU - Miki, Yoshitsugu

AU - Kuritani, Taro

AU - Kishi, Hiroyuki

AU - Kishimoto, Susumu

AU - Yamamura, Yuichi

AU - Kishimoto, Tadamitsu

PY - 1982/5

Y1 - 1982/5

N2 - T-cell functions of patients with sarcoidosis were studied by employing PWM-induced immunoglobulin (Ig) synthesis and PHA-induced T-cell colony formation. Con A-induced suppressor function as well as helper function in PWM-induced Ig production was markedly depressed in T cells from patients with sarcoidosis. PHA-induced T colony formation was also found to be markedly depressed in patients with sarcoidosis. However, the depressed colony formation was recovered by depletion of macrophages or by addition of indomethacin. The addition of the soluble factors derived from patients' macrophages suppressed the colony formation of T cells from healthy adult volunteers. Taken together, the results suggest that the presence of suppressor macrophages may induce the depressed state of several T-cell functions in patients with sarcoidosis.

AB - T-cell functions of patients with sarcoidosis were studied by employing PWM-induced immunoglobulin (Ig) synthesis and PHA-induced T-cell colony formation. Con A-induced suppressor function as well as helper function in PWM-induced Ig production was markedly depressed in T cells from patients with sarcoidosis. PHA-induced T colony formation was also found to be markedly depressed in patients with sarcoidosis. However, the depressed colony formation was recovered by depletion of macrophages or by addition of indomethacin. The addition of the soluble factors derived from patients' macrophages suppressed the colony formation of T cells from healthy adult volunteers. Taken together, the results suggest that the presence of suppressor macrophages may induce the depressed state of several T-cell functions in patients with sarcoidosis.

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Depressed functions of T cells and the presence of suppressor macrophages in patients with sarcoidosis

Abstract

ASJC Scopus subject areas

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