Decreased number of orbital sulci in schizophrenia spectrum disorders

Tsutomu Takahashi; Mihoko Nakamura; Yumiko Nishikawa; Yoichiro Takayanagi; Atsushi Furuichi; Mikio Kido; Daiki Sasabayashi; Kyo Noguchi; Michio Suzuki

doi:10.1016/j.pscychresns.2016.03.005

Decreased number of orbital sulci in schizophrenia spectrum disorders

Tsutomu Takahashi^*, Mihoko Nakamura, Yumiko Nishikawa, Yoichiro Takayanagi, Atsushi Furuichi, Mikio Kido, Daiki Sasabayashi, Kyo Noguchi, Michio Suzuki

^*この論文の責任著者

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

11 被引用数 (Scopus)

抄録

An altered orbitofrontal sulcogyral pattern has been reported in the schizophrenia-spectrum, but it remains unknown whether they also have differences in the number of intermediate and posterior orbital sulci compared with healthy subjects. This magnetic resonance imaging study investigated the number of these sulci in 102 schizophrenia patients, 47 schizotypal disorder patients, and 84 controls. Both patient groups had a significantly lower number of both sulci bilaterally compared with controls, which was weakly associated with the severity of negative symptoms. Our results may reflect the neurodevelopmental pathology related to vulnerability to psychosis.

本文言語	英語
ページ（範囲）	29-32
ページ数	4
ジャーナル	Psychiatry Research - Neuroimaging
巻	250
DOI	https://doi.org/10.1016/j.pscychresns.2016.03.005
出版ステータス	出版済み - 2016/04/30

ASJC Scopus 主題領域

神経科学（その他）
放射線学、核医学およびイメージング
精神医学および精神衛生

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.1016/j.pscychresns.2016.03.005

引用スタイル

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title = "Decreased number of orbital sulci in schizophrenia spectrum disorders",

abstract = "An altered orbitofrontal sulcogyral pattern has been reported in the schizophrenia-spectrum, but it remains unknown whether they also have differences in the number of intermediate and posterior orbital sulci compared with healthy subjects. This magnetic resonance imaging study investigated the number of these sulci in 102 schizophrenia patients, 47 schizotypal disorder patients, and 84 controls. Both patient groups had a significantly lower number of both sulci bilaterally compared with controls, which was weakly associated with the severity of negative symptoms. Our results may reflect the neurodevelopmental pathology related to vulnerability to psychosis.",

keywords = "Magnetic resonance imaging, Orbitofrontal cortex, Schizotypal disorder",

author = "Tsutomu Takahashi and Mihoko Nakamura and Yumiko Nishikawa and Yoichiro Takayanagi and Atsushi Furuichi and Mikio Kido and Daiki Sasabayashi and Kyo Noguchi and Michio Suzuki",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ireland Ltd.",

year = "2016",

month = apr,

day = "30",

doi = "10.1016/j.pscychresns.2016.03.005",

language = "英語",

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journal = "Psychiatry Research - Neuroimaging",

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T1 - Decreased number of orbital sulci in schizophrenia spectrum disorders

AU - Takahashi, Tsutomu

AU - Nakamura, Mihoko

AU - Nishikawa, Yumiko

AU - Takayanagi, Yoichiro

AU - Furuichi, Atsushi

AU - Kido, Mikio

AU - Sasabayashi, Daiki

AU - Noguchi, Kyo

AU - Suzuki, Michio

PY - 2016/4/30

Y1 - 2016/4/30

N2 - An altered orbitofrontal sulcogyral pattern has been reported in the schizophrenia-spectrum, but it remains unknown whether they also have differences in the number of intermediate and posterior orbital sulci compared with healthy subjects. This magnetic resonance imaging study investigated the number of these sulci in 102 schizophrenia patients, 47 schizotypal disorder patients, and 84 controls. Both patient groups had a significantly lower number of both sulci bilaterally compared with controls, which was weakly associated with the severity of negative symptoms. Our results may reflect the neurodevelopmental pathology related to vulnerability to psychosis.

AB - An altered orbitofrontal sulcogyral pattern has been reported in the schizophrenia-spectrum, but it remains unknown whether they also have differences in the number of intermediate and posterior orbital sulci compared with healthy subjects. This magnetic resonance imaging study investigated the number of these sulci in 102 schizophrenia patients, 47 schizotypal disorder patients, and 84 controls. Both patient groups had a significantly lower number of both sulci bilaterally compared with controls, which was weakly associated with the severity of negative symptoms. Our results may reflect the neurodevelopmental pathology related to vulnerability to psychosis.

KW - Magnetic resonance imaging

KW - Orbitofrontal cortex

KW - Schizotypal disorder

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U2 - 10.1016/j.pscychresns.2016.03.005

DO - 10.1016/j.pscychresns.2016.03.005

M3 - 学術論文

C2 - 27017422

AN - SCOPUS:84962520270

SN - 0925-4927

VL - 250

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JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

ER -

Decreased number of orbital sulci in schizophrenia spectrum disorders

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ASJC Scopus 主題領域

UN SDG

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