Decreased number of orbital sulci in schizophrenia spectrum disorders

Tsutomu Takahashi; Mihoko Nakamura; Yumiko Nishikawa; Yoichiro Takayanagi; Atsushi Furuichi; Mikio Kido; Daiki Sasabayashi; Kyo Noguchi; Michio Suzuki

doi:10.1016/j.pscychresns.2016.03.005

Decreased number of orbital sulci in schizophrenia spectrum disorders

Tsutomu Takahashi^*, Mihoko Nakamura, Yumiko Nishikawa, Yoichiro Takayanagi, Atsushi Furuichi, Mikio Kido, Daiki Sasabayashi, Kyo Noguchi, Michio Suzuki

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

An altered orbitofrontal sulcogyral pattern has been reported in the schizophrenia-spectrum, but it remains unknown whether they also have differences in the number of intermediate and posterior orbital sulci compared with healthy subjects. This magnetic resonance imaging study investigated the number of these sulci in 102 schizophrenia patients, 47 schizotypal disorder patients, and 84 controls. Both patient groups had a significantly lower number of both sulci bilaterally compared with controls, which was weakly associated with the severity of negative symptoms. Our results may reflect the neurodevelopmental pathology related to vulnerability to psychosis.

Original language	English
Pages (from-to)	29-32
Number of pages	4
Journal	Psychiatry Research - Neuroimaging
Volume	250
DOIs	https://doi.org/10.1016/j.pscychresns.2016.03.005
State	Published - 2016/04/30

Keywords

Magnetic resonance imaging
Orbitofrontal cortex
Schizotypal disorder

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pscychresns.2016.03.005

Cite this

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title = "Decreased number of orbital sulci in schizophrenia spectrum disorders",

abstract = "An altered orbitofrontal sulcogyral pattern has been reported in the schizophrenia-spectrum, but it remains unknown whether they also have differences in the number of intermediate and posterior orbital sulci compared with healthy subjects. This magnetic resonance imaging study investigated the number of these sulci in 102 schizophrenia patients, 47 schizotypal disorder patients, and 84 controls. Both patient groups had a significantly lower number of both sulci bilaterally compared with controls, which was weakly associated with the severity of negative symptoms. Our results may reflect the neurodevelopmental pathology related to vulnerability to psychosis.",

keywords = "Magnetic resonance imaging, Orbitofrontal cortex, Schizotypal disorder",

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day = "30",

doi = "10.1016/j.pscychresns.2016.03.005",

language = "英語",

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T1 - Decreased number of orbital sulci in schizophrenia spectrum disorders

AU - Takahashi, Tsutomu

AU - Nakamura, Mihoko

AU - Nishikawa, Yumiko

AU - Takayanagi, Yoichiro

AU - Furuichi, Atsushi

AU - Kido, Mikio

AU - Sasabayashi, Daiki

AU - Noguchi, Kyo

AU - Suzuki, Michio

PY - 2016/4/30

Y1 - 2016/4/30

N2 - An altered orbitofrontal sulcogyral pattern has been reported in the schizophrenia-spectrum, but it remains unknown whether they also have differences in the number of intermediate and posterior orbital sulci compared with healthy subjects. This magnetic resonance imaging study investigated the number of these sulci in 102 schizophrenia patients, 47 schizotypal disorder patients, and 84 controls. Both patient groups had a significantly lower number of both sulci bilaterally compared with controls, which was weakly associated with the severity of negative symptoms. Our results may reflect the neurodevelopmental pathology related to vulnerability to psychosis.

AB - An altered orbitofrontal sulcogyral pattern has been reported in the schizophrenia-spectrum, but it remains unknown whether they also have differences in the number of intermediate and posterior orbital sulci compared with healthy subjects. This magnetic resonance imaging study investigated the number of these sulci in 102 schizophrenia patients, 47 schizotypal disorder patients, and 84 controls. Both patient groups had a significantly lower number of both sulci bilaterally compared with controls, which was weakly associated with the severity of negative symptoms. Our results may reflect the neurodevelopmental pathology related to vulnerability to psychosis.

KW - Magnetic resonance imaging

KW - Orbitofrontal cortex

KW - Schizotypal disorder

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DO - 10.1016/j.pscychresns.2016.03.005

M3 - 学術論文

C2 - 27017422

AN - SCOPUS:84962520270

SN - 0925-4927

VL - 250

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JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

ER -

Decreased number of orbital sulci in schizophrenia spectrum disorders

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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