Damnacanthal from the congolese medicinal plant Garcinia huillensis has a potent preferential cytotoxicity against human pancreatic cancer PANC-1 cells

Dya Fita Dibwe; Suresh Awale; Shigetoshi Kadota; Yasuhiro Tezuka

doi:10.1002/ptr.4672

Damnacanthal from the congolese medicinal plant Garcinia huillensis has a potent preferential cytotoxicity against human pancreatic cancer PANC-1 cells

Dya Fita Dibwe, Suresh Awale, Shigetoshi Kadota, Yasuhiro Tezuka^*

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

30 被引用数 (Scopus)

抄録

Screening of eight Congolese medicinal plants showed that the CHCl ₃ and MeOH extracts of Aframomum melegueta (PC₅₀ = 47.8 μg/mL and 13.8 μg/mL, respectively) and CHCl₃ extracts of Garcinia huillensis (PC₅₀ = 17.8 μg/mL) and Securidaca longepedunculata (PC₅₀ = 23.4 μg/mL) had preferential cytotoxicity against human pancreatic cancer PANC-1 cells under nutrient-deprived conditions. The active constituents of the CHCl₃ extract of G. huillensis were examined and 12 known anthraquinones were identified. Among them, damnacanthal (1) caused preferential necrotic cell death of PANC-1 and PSN-1 cells under nutrient-deprived and serum-sensitive conditions (PC ₅₀ = 4.46 μm and 3.77 μm, respectively).

本文言語	英語
ページ（範囲）	1920-1926
ページ数	7
ジャーナル	Phytotherapy Research
巻	26
号	12
DOI	https://doi.org/10.1002/ptr.4672
出版ステータス	出版済み - 2012/12

ASJC Scopus 主題領域

薬理学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.1002/ptr.4672

フィンガープリント

「Damnacanthal from the congolese medicinal plant Garcinia huillensis has a potent preferential cytotoxicity against human pancreatic cancer PANC-1 cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

@article{1c9eedf61a664dabaff82a7f5a88ccfb,

title = "Damnacanthal from the congolese medicinal plant Garcinia huillensis has a potent preferential cytotoxicity against human pancreatic cancer PANC-1 cells",

abstract = "Screening of eight Congolese medicinal plants showed that the CHCl 3 and MeOH extracts of Aframomum melegueta (PC50 = 47.8 μg/mL and 13.8 μg/mL, respectively) and CHCl3 extracts of Garcinia huillensis (PC50 = 17.8 μg/mL) and Securidaca longepedunculata (PC50 = 23.4 μg/mL) had preferential cytotoxicity against human pancreatic cancer PANC-1 cells under nutrient-deprived conditions. The active constituents of the CHCl3 extract of G. huillensis were examined and 12 known anthraquinones were identified. Among them, damnacanthal (1) caused preferential necrotic cell death of PANC-1 and PSN-1 cells under nutrient-deprived and serum-sensitive conditions (PC 50 = 4.46 μm and 3.77 μm, respectively).",

keywords = "Garcinia huillensis, anthraquinone, damnacanthal, pancreatic cancer, preferential cytotoxicity",

author = "Dibwe, {Dya Fita} and Suresh Awale and Shigetoshi Kadota and Yasuhiro Tezuka",

year = "2012",

month = dec,

doi = "10.1002/ptr.4672",

language = "英語",

volume = "26",

pages = "1920--1926",

journal = "Phytotherapy Research",

issn = "0951-418X",

publisher = "John Wiley and Sons Ltd",

number = "12",

}

TY - JOUR

T1 - Damnacanthal from the congolese medicinal plant Garcinia huillensis has a potent preferential cytotoxicity against human pancreatic cancer PANC-1 cells

AU - Dibwe, Dya Fita

AU - Awale, Suresh

AU - Kadota, Shigetoshi

AU - Tezuka, Yasuhiro

PY - 2012/12

Y1 - 2012/12

N2 - Screening of eight Congolese medicinal plants showed that the CHCl 3 and MeOH extracts of Aframomum melegueta (PC50 = 47.8 μg/mL and 13.8 μg/mL, respectively) and CHCl3 extracts of Garcinia huillensis (PC50 = 17.8 μg/mL) and Securidaca longepedunculata (PC50 = 23.4 μg/mL) had preferential cytotoxicity against human pancreatic cancer PANC-1 cells under nutrient-deprived conditions. The active constituents of the CHCl3 extract of G. huillensis were examined and 12 known anthraquinones were identified. Among them, damnacanthal (1) caused preferential necrotic cell death of PANC-1 and PSN-1 cells under nutrient-deprived and serum-sensitive conditions (PC 50 = 4.46 μm and 3.77 μm, respectively).

AB - Screening of eight Congolese medicinal plants showed that the CHCl 3 and MeOH extracts of Aframomum melegueta (PC50 = 47.8 μg/mL and 13.8 μg/mL, respectively) and CHCl3 extracts of Garcinia huillensis (PC50 = 17.8 μg/mL) and Securidaca longepedunculata (PC50 = 23.4 μg/mL) had preferential cytotoxicity against human pancreatic cancer PANC-1 cells under nutrient-deprived conditions. The active constituents of the CHCl3 extract of G. huillensis were examined and 12 known anthraquinones were identified. Among them, damnacanthal (1) caused preferential necrotic cell death of PANC-1 and PSN-1 cells under nutrient-deprived and serum-sensitive conditions (PC 50 = 4.46 μm and 3.77 μm, respectively).

KW - Garcinia huillensis

KW - anthraquinone

KW - damnacanthal

KW - pancreatic cancer

KW - preferential cytotoxicity

UR - http://www.scopus.com/inward/record.url?scp=84871307819&partnerID=8YFLogxK

U2 - 10.1002/ptr.4672

DO - 10.1002/ptr.4672

M3 - 学術論文

C2 - 22447631

AN - SCOPUS:84871307819

SN - 0951-418X

VL - 26

SP - 1920

EP - 1926

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 12

ER -