Damnacanthal from the congolese medicinal plant Garcinia huillensis has a potent preferential cytotoxicity against human pancreatic cancer PANC-1 cells

Dya Fita Dibwe; Suresh Awale; Shigetoshi Kadota; Yasuhiro Tezuka

doi:10.1002/ptr.4672

Damnacanthal from the congolese medicinal plant Garcinia huillensis has a potent preferential cytotoxicity against human pancreatic cancer PANC-1 cells

Dya Fita Dibwe, Suresh Awale, Shigetoshi Kadota, Yasuhiro Tezuka^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Screening of eight Congolese medicinal plants showed that the CHCl ₃ and MeOH extracts of Aframomum melegueta (PC₅₀ = 47.8 μg/mL and 13.8 μg/mL, respectively) and CHCl₃ extracts of Garcinia huillensis (PC₅₀ = 17.8 μg/mL) and Securidaca longepedunculata (PC₅₀ = 23.4 μg/mL) had preferential cytotoxicity against human pancreatic cancer PANC-1 cells under nutrient-deprived conditions. The active constituents of the CHCl₃ extract of G. huillensis were examined and 12 known anthraquinones were identified. Among them, damnacanthal (1) caused preferential necrotic cell death of PANC-1 and PSN-1 cells under nutrient-deprived and serum-sensitive conditions (PC ₅₀ = 4.46 μm and 3.77 μm, respectively).

Original language	English
Pages (from-to)	1920-1926
Number of pages	7
Journal	Phytotherapy Research
Volume	26
Issue number	12
DOIs	https://doi.org/10.1002/ptr.4672
State	Published - 2012/12

Keywords

Garcinia huillensis
anthraquinone
damnacanthal
pancreatic cancer
preferential cytotoxicity

ASJC Scopus subject areas

Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ptr.4672

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title = "Damnacanthal from the congolese medicinal plant Garcinia huillensis has a potent preferential cytotoxicity against human pancreatic cancer PANC-1 cells",

abstract = "Screening of eight Congolese medicinal plants showed that the CHCl 3 and MeOH extracts of Aframomum melegueta (PC50 = 47.8 μg/mL and 13.8 μg/mL, respectively) and CHCl3 extracts of Garcinia huillensis (PC50 = 17.8 μg/mL) and Securidaca longepedunculata (PC50 = 23.4 μg/mL) had preferential cytotoxicity against human pancreatic cancer PANC-1 cells under nutrient-deprived conditions. The active constituents of the CHCl3 extract of G. huillensis were examined and 12 known anthraquinones were identified. Among them, damnacanthal (1) caused preferential necrotic cell death of PANC-1 and PSN-1 cells under nutrient-deprived and serum-sensitive conditions (PC 50 = 4.46 μm and 3.77 μm, respectively).",

keywords = "Garcinia huillensis, anthraquinone, damnacanthal, pancreatic cancer, preferential cytotoxicity",

author = "Dibwe, {Dya Fita} and Suresh Awale and Shigetoshi Kadota and Yasuhiro Tezuka",

year = "2012",

month = dec,

doi = "10.1002/ptr.4672",

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T1 - Damnacanthal from the congolese medicinal plant Garcinia huillensis has a potent preferential cytotoxicity against human pancreatic cancer PANC-1 cells

AU - Dibwe, Dya Fita

AU - Awale, Suresh

AU - Kadota, Shigetoshi

AU - Tezuka, Yasuhiro

PY - 2012/12

Y1 - 2012/12

N2 - Screening of eight Congolese medicinal plants showed that the CHCl 3 and MeOH extracts of Aframomum melegueta (PC50 = 47.8 μg/mL and 13.8 μg/mL, respectively) and CHCl3 extracts of Garcinia huillensis (PC50 = 17.8 μg/mL) and Securidaca longepedunculata (PC50 = 23.4 μg/mL) had preferential cytotoxicity against human pancreatic cancer PANC-1 cells under nutrient-deprived conditions. The active constituents of the CHCl3 extract of G. huillensis were examined and 12 known anthraquinones were identified. Among them, damnacanthal (1) caused preferential necrotic cell death of PANC-1 and PSN-1 cells under nutrient-deprived and serum-sensitive conditions (PC 50 = 4.46 μm and 3.77 μm, respectively).

AB - Screening of eight Congolese medicinal plants showed that the CHCl 3 and MeOH extracts of Aframomum melegueta (PC50 = 47.8 μg/mL and 13.8 μg/mL, respectively) and CHCl3 extracts of Garcinia huillensis (PC50 = 17.8 μg/mL) and Securidaca longepedunculata (PC50 = 23.4 μg/mL) had preferential cytotoxicity against human pancreatic cancer PANC-1 cells under nutrient-deprived conditions. The active constituents of the CHCl3 extract of G. huillensis were examined and 12 known anthraquinones were identified. Among them, damnacanthal (1) caused preferential necrotic cell death of PANC-1 and PSN-1 cells under nutrient-deprived and serum-sensitive conditions (PC 50 = 4.46 μm and 3.77 μm, respectively).

KW - Garcinia huillensis

KW - anthraquinone

KW - damnacanthal

KW - pancreatic cancer

KW - preferential cytotoxicity

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DO - 10.1002/ptr.4672

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SN - 0951-418X

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IS - 12

ER -

Damnacanthal from the congolese medicinal plant Garcinia huillensis has a potent preferential cytotoxicity against human pancreatic cancer PANC-1 cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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