TY - JOUR
T1 - Cytotoxicity of constituents from Mexican propolis against a panel of six different cancer cell lines
AU - Li, Feng
AU - Awale, Suresh
AU - Tezuka, Yasuhiro
AU - Kadota, Shigetoshi
PY - 2010
Y1 - 2010
N2 - The cytotoxicity of 39 compounds, including eighteen flavonoids (flavanones, 1-10; flavones, 11-17; flavanol, 18), sixteen phenolic acid derivatives (aromatic acids, 19-24; aldehyde, 25; esters, 26-34) and five glycerides (35-39), isolated from Mexican propolis, were evaluated against a panel of six different cancer cell lines; murine colon 26-L5 carcinoma, murine B16-BL6 melanoma, murine Lewis lung carcinoma, human lung A549 adenocarcinoma, human cervix HeLa adenocarcinoma and human HT-1080 fibrosarcoma. A phenylpropanoid-substituted flavanol, (2R,3S)-8-[4-phenylprop-2-en-1-one]- 4′,7-dihydroxy-3′,5-dimethoxyflavan-3-ol (18), showed the most potent cytotoxicity against A549 cells (IC50, 6.2 μM) and HT-1080 cells (IC50, 3.9 μM), stronger than those of the clinically used anticancer drug, 5-fluorouracil (IC50, 7.5 μM and 5.4 μM, respectively). Based on the observed results, the structure-activity relationships are discussed.
AB - The cytotoxicity of 39 compounds, including eighteen flavonoids (flavanones, 1-10; flavones, 11-17; flavanol, 18), sixteen phenolic acid derivatives (aromatic acids, 19-24; aldehyde, 25; esters, 26-34) and five glycerides (35-39), isolated from Mexican propolis, were evaluated against a panel of six different cancer cell lines; murine colon 26-L5 carcinoma, murine B16-BL6 melanoma, murine Lewis lung carcinoma, human lung A549 adenocarcinoma, human cervix HeLa adenocarcinoma and human HT-1080 fibrosarcoma. A phenylpropanoid-substituted flavanol, (2R,3S)-8-[4-phenylprop-2-en-1-one]- 4′,7-dihydroxy-3′,5-dimethoxyflavan-3-ol (18), showed the most potent cytotoxicity against A549 cells (IC50, 6.2 μM) and HT-1080 cells (IC50, 3.9 μM), stronger than those of the clinically used anticancer drug, 5-fluorouracil (IC50, 7.5 μM and 5.4 μM, respectively). Based on the observed results, the structure-activity relationships are discussed.
KW - Cytotoxicity
KW - Flavonoids
KW - Phenolic acid derivatives
KW - Phenylpropanoid glycerides
KW - Propolis
KW - Structure-activity relationship
UR - http://www.scopus.com/inward/record.url?scp=77957910787&partnerID=8YFLogxK
U2 - 10.1177/1934578x1000501018
DO - 10.1177/1934578x1000501018
M3 - 学術論文
C2 - 21121257
AN - SCOPUS:77957910787
SN - 1934-578X
VL - 5
SP - 1601
EP - 1606
JO - Natural Product Communications
JF - Natural Product Communications
IS - 10
ER -