Cytotoxicity of constituents from Mexican propolis against a panel of six different cancer cell lines

Feng Li; Suresh Awale; Yasuhiro Tezuka; Shigetoshi Kadota

doi:10.1177/1934578x1000501018

Cytotoxicity of constituents from Mexican propolis against a panel of six different cancer cell lines

Feng Li, Suresh Awale, Yasuhiro Tezuka, Shigetoshi Kadota^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The cytotoxicity of 39 compounds, including eighteen flavonoids (flavanones, 1-10; flavones, 11-17; flavanol, 18), sixteen phenolic acid derivatives (aromatic acids, 19-24; aldehyde, 25; esters, 26-34) and five glycerides (35-39), isolated from Mexican propolis, were evaluated against a panel of six different cancer cell lines; murine colon 26-L5 carcinoma, murine B16-BL6 melanoma, murine Lewis lung carcinoma, human lung A549 adenocarcinoma, human cervix HeLa adenocarcinoma and human HT-1080 fibrosarcoma. A phenylpropanoid-substituted flavanol, (2R,3S)-8-[4-phenylprop-2-en-1-one]- 4′,7-dihydroxy-3′,5-dimethoxyflavan-3-ol (18), showed the most potent cytotoxicity against A549 cells (IC₅₀, 6.2 μM) and HT-1080 cells (IC₅₀, 3.9 μM), stronger than those of the clinically used anticancer drug, 5-fluorouracil (IC₅₀, 7.5 μM and 5.4 μM, respectively). Based on the observed results, the structure-activity relationships are discussed.

Original language	English
Pages (from-to)	1601-1606
Number of pages	6
Journal	Natural Product Communications
Volume	5
Issue number	10
DOIs	https://doi.org/10.1177/1934578x1000501018
State	Published - 2010

Keywords

Cytotoxicity
Flavonoids
Phenolic acid derivatives
Phenylpropanoid glycerides
Propolis
Structure-activity relationship

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

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10.1177/1934578x1000501018

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title = "Cytotoxicity of constituents from Mexican propolis against a panel of six different cancer cell lines",

abstract = "The cytotoxicity of 39 compounds, including eighteen flavonoids (flavanones, 1-10; flavones, 11-17; flavanol, 18), sixteen phenolic acid derivatives (aromatic acids, 19-24; aldehyde, 25; esters, 26-34) and five glycerides (35-39), isolated from Mexican propolis, were evaluated against a panel of six different cancer cell lines; murine colon 26-L5 carcinoma, murine B16-BL6 melanoma, murine Lewis lung carcinoma, human lung A549 adenocarcinoma, human cervix HeLa adenocarcinoma and human HT-1080 fibrosarcoma. A phenylpropanoid-substituted flavanol, (2R,3S)-8-[4-phenylprop-2-en-1-one]- 4′,7-dihydroxy-3′,5-dimethoxyflavan-3-ol (18), showed the most potent cytotoxicity against A549 cells (IC50, 6.2 μM) and HT-1080 cells (IC50, 3.9 μM), stronger than those of the clinically used anticancer drug, 5-fluorouracil (IC50, 7.5 μM and 5.4 μM, respectively). Based on the observed results, the structure-activity relationships are discussed.",

keywords = "Cytotoxicity, Flavonoids, Phenolic acid derivatives, Phenylpropanoid glycerides, Propolis, Structure-activity relationship",

author = "Feng Li and Suresh Awale and Yasuhiro Tezuka and Shigetoshi Kadota",

year = "2010",

doi = "10.1177/1934578x1000501018",

language = "英語",

volume = "5",

pages = "1601--1606",

journal = "Natural Product Communications",

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T1 - Cytotoxicity of constituents from Mexican propolis against a panel of six different cancer cell lines

AU - Li, Feng

AU - Awale, Suresh

AU - Tezuka, Yasuhiro

AU - Kadota, Shigetoshi

PY - 2010

Y1 - 2010

N2 - The cytotoxicity of 39 compounds, including eighteen flavonoids (flavanones, 1-10; flavones, 11-17; flavanol, 18), sixteen phenolic acid derivatives (aromatic acids, 19-24; aldehyde, 25; esters, 26-34) and five glycerides (35-39), isolated from Mexican propolis, were evaluated against a panel of six different cancer cell lines; murine colon 26-L5 carcinoma, murine B16-BL6 melanoma, murine Lewis lung carcinoma, human lung A549 adenocarcinoma, human cervix HeLa adenocarcinoma and human HT-1080 fibrosarcoma. A phenylpropanoid-substituted flavanol, (2R,3S)-8-[4-phenylprop-2-en-1-one]- 4′,7-dihydroxy-3′,5-dimethoxyflavan-3-ol (18), showed the most potent cytotoxicity against A549 cells (IC50, 6.2 μM) and HT-1080 cells (IC50, 3.9 μM), stronger than those of the clinically used anticancer drug, 5-fluorouracil (IC50, 7.5 μM and 5.4 μM, respectively). Based on the observed results, the structure-activity relationships are discussed.

AB - The cytotoxicity of 39 compounds, including eighteen flavonoids (flavanones, 1-10; flavones, 11-17; flavanol, 18), sixteen phenolic acid derivatives (aromatic acids, 19-24; aldehyde, 25; esters, 26-34) and five glycerides (35-39), isolated from Mexican propolis, were evaluated against a panel of six different cancer cell lines; murine colon 26-L5 carcinoma, murine B16-BL6 melanoma, murine Lewis lung carcinoma, human lung A549 adenocarcinoma, human cervix HeLa adenocarcinoma and human HT-1080 fibrosarcoma. A phenylpropanoid-substituted flavanol, (2R,3S)-8-[4-phenylprop-2-en-1-one]- 4′,7-dihydroxy-3′,5-dimethoxyflavan-3-ol (18), showed the most potent cytotoxicity against A549 cells (IC50, 6.2 μM) and HT-1080 cells (IC50, 3.9 μM), stronger than those of the clinically used anticancer drug, 5-fluorouracil (IC50, 7.5 μM and 5.4 μM, respectively). Based on the observed results, the structure-activity relationships are discussed.

KW - Cytotoxicity

KW - Flavonoids

KW - Phenolic acid derivatives

KW - Phenylpropanoid glycerides

KW - Propolis

KW - Structure-activity relationship

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U2 - 10.1177/1934578x1000501018

DO - 10.1177/1934578x1000501018

M3 - 学術論文

C2 - 21121257

AN - SCOPUS:77957910787

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SP - 1601

EP - 1606

JO - Natural Product Communications

JF - Natural Product Communications

IS - 10

ER -

Cytotoxicity of constituents from Mexican propolis against a panel of six different cancer cell lines

Abstract

Keywords

ASJC Scopus subject areas

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