抄録
Genes differentially expressed in the subjective day and night in the rat suprachiasmatic nucleus (SCN) were surveyed by differential display. A gene homologous to human casein kinase 1ε (CK1ε) was isolated, which initially appeared to be expressed in the suprachiasmatic nucleus (SCN) in a circadian manner. We here describe the cDNA cloning of the rat CK1ε and characterization of the protein products. The rCK1ε is predominantly expressed in the brain including the SCN, binds and phosphorylates mPer1, mPer2, and mPer3 in vitro, and translocates mPer1 and mPer3, but not mPer2, to the cell nucleus depending on its kinase activity when coexpressed with these Per proteins in COS-7 cells. Copyright (C) 2000 Federation of European Biochemical Societies.
本文言語 | 英語 |
---|---|
ページ(範囲) | 106-112 |
ページ数 | 7 |
ジャーナル | FEBS Letters |
巻 | 477 |
号 | 1-2 |
DOI | |
出版ステータス | 出版済み - 2000/07/14 |
ASJC Scopus 主題領域
- 生物理学
- 構造生物学
- 生化学
- 分子生物学
- 遺伝学
- 細胞生物学