@article{67c72d5cbfac4243a4700ffaf811bacf,
title = "Cleistanthane diterpenes from the seed of Caesalpinia sappan and their antiausterity activity against PANC-1 human pancreatic cancer cell line",
abstract = "Three new cleistanthane diterpenes named tomocinon (1), tomocinol A (2), and tomocinol B (3), were isolated from the EtOAc extract of the seed of Caesalpinia sappan. Their structures were determined by extensive NMR spectroscopic analysis. The absolute stereochemistry of tomocinon (1) has been established by CD spectroscopic analysis. Cleistanthane diterpenes (1-3) represents the novel class of antiausterity agents having preferential cytotoxicity against PANC-1 human pancreatic cancer cell line under nutrient deprived condition with PC50 value of 34.7 μM, 42.4 μM and 39.4 μM, respectively.",
keywords = "Antiausterity strategy, Anticancer drug discovery, Caesalpinia sappan, Cleistanthane diterpene, Nutrient starvation, PANC-1",
author = "Nguyen, {Hai Xuan} and Nguyen, {Mai Thanh Thi} and Nguyen, {Thy Anh} and Nguyen, {Nhi Y.Thi} and Phan, {Dao Anh Thi} and Thi, {Phuoc Ho} and Nguyen, {Trong Huu Phan} and Dang, {Phu Hoang} and Nguyen, {Nhan Trung} and Ueda, {Jun Ya} and Suresh Awale",
note = "Funding Information: This work was supported by grant B2011-18-04TD from the Vietnam National University-Ho Chi Minh City (VNU-HCM) to MTTN, a grant from the Toyama Support Center for Young Principal Investigators in Advanced Life Sciences, Japan , and a Grant in Aid for Scientific Research (No. 24510314 ) from the Japan Society for the Promotion of Science (JSPS) to SA. ",
year = "2013",
doi = "10.1016/j.fitote.2013.08.018",
language = "英語",
volume = "91",
pages = "148--153",
journal = "Fitoterapia",
issn = "0367-326X",
publisher = "Elsevier B.V.",
}
