Cleistanthane diterpenes from the seed of Caesalpinia sappan and their antiausterity activity against PANC-1 human pancreatic cancer cell line

Hai Xuan Nguyen; Mai Thanh Thi Nguyen; Thy Anh Nguyen; Nhi Y.Thi Nguyen; Dao Anh Thi Phan; Phuoc Ho Thi; Trong Huu Phan Nguyen; Phu Hoang Dang; Nhan Trung Nguyen; Jun Ya Ueda; Suresh Awale

doi:10.1016/j.fitote.2013.08.018

Cleistanthane diterpenes from the seed of Caesalpinia sappan and their antiausterity activity against PANC-1 human pancreatic cancer cell line

Hai Xuan Nguyen, Mai Thanh Thi Nguyen, Thy Anh Nguyen, Nhi Y.Thi Nguyen, Dao Anh Thi Phan, Phuoc Ho Thi, Trong Huu Phan Nguyen, Phu Hoang Dang, Nhan Trung Nguyen, Jun Ya Ueda, Suresh Awale^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Three new cleistanthane diterpenes named tomocinon (1), tomocinol A (2), and tomocinol B (3), were isolated from the EtOAc extract of the seed of Caesalpinia sappan. Their structures were determined by extensive NMR spectroscopic analysis. The absolute stereochemistry of tomocinon (1) has been established by CD spectroscopic analysis. Cleistanthane diterpenes (1-3) represents the novel class of antiausterity agents having preferential cytotoxicity against PANC-1 human pancreatic cancer cell line under nutrient deprived condition with PC₅₀ value of 34.7 μM, 42.4 μM and 39.4 μM, respectively.

Original language	English
Pages (from-to)	148-153
Number of pages	6
Journal	Fitoterapia
Volume	91
DOIs	https://doi.org/10.1016/j.fitote.2013.08.018
State	Published - 2013

Keywords

Antiausterity strategy
Anticancer drug discovery
Caesalpinia sappan
Cleistanthane diterpene
Nutrient starvation
PANC-1

ASJC Scopus subject areas

Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.fitote.2013.08.018

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Nguyen, H. X., Nguyen, M. T. T., Nguyen, T. A., Nguyen, N. Y. T., Phan, D. A. T., Thi, P. H., Nguyen, T. H. P., Dang, P. H., Nguyen, N. T., Ueda, J. Y., & Awale, S. (2013). Cleistanthane diterpenes from the seed of Caesalpinia sappan and their antiausterity activity against PANC-1 human pancreatic cancer cell line. Fitoterapia, 91, 148-153. https://doi.org/10.1016/j.fitote.2013.08.018

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title = "Cleistanthane diterpenes from the seed of Caesalpinia sappan and their antiausterity activity against PANC-1 human pancreatic cancer cell line",

abstract = "Three new cleistanthane diterpenes named tomocinon (1), tomocinol A (2), and tomocinol B (3), were isolated from the EtOAc extract of the seed of Caesalpinia sappan. Their structures were determined by extensive NMR spectroscopic analysis. The absolute stereochemistry of tomocinon (1) has been established by CD spectroscopic analysis. Cleistanthane diterpenes (1-3) represents the novel class of antiausterity agents having preferential cytotoxicity against PANC-1 human pancreatic cancer cell line under nutrient deprived condition with PC50 value of 34.7 μM, 42.4 μM and 39.4 μM, respectively.",

keywords = "Antiausterity strategy, Anticancer drug discovery, Caesalpinia sappan, Cleistanthane diterpene, Nutrient starvation, PANC-1",

author = "Nguyen, {Hai Xuan} and Nguyen, {Mai Thanh Thi} and Nguyen, {Thy Anh} and Nguyen, {Nhi Y.Thi} and Phan, {Dao Anh Thi} and Thi, {Phuoc Ho} and Nguyen, {Trong Huu Phan} and Dang, {Phu Hoang} and Nguyen, {Nhan Trung} and Ueda, {Jun Ya} and Suresh Awale",

note = "Funding Information: This work was supported by grant B2011-18-04TD from the Vietnam National University-Ho Chi Minh City (VNU-HCM) to MTTN, a grant from the Toyama Support Center for Young Principal Investigators in Advanced Life Sciences, Japan , and a Grant in Aid for Scientific Research (No. 24510314 ) from the Japan Society for the Promotion of Science (JSPS) to SA. ",

year = "2013",

doi = "10.1016/j.fitote.2013.08.018",

language = "英語",

volume = "91",

pages = "148--153",

journal = "Fitoterapia",

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AU - Nguyen, Hai Xuan

AU - Nguyen, Mai Thanh Thi

AU - Nguyen, Thy Anh

AU - Nguyen, Nhi Y.Thi

AU - Phan, Dao Anh Thi

AU - Thi, Phuoc Ho

AU - Nguyen, Trong Huu Phan

AU - Dang, Phu Hoang

AU - Nguyen, Nhan Trung

AU - Ueda, Jun Ya

AU - Awale, Suresh

N1 - Funding Information: This work was supported by grant B2011-18-04TD from the Vietnam National University-Ho Chi Minh City (VNU-HCM) to MTTN, a grant from the Toyama Support Center for Young Principal Investigators in Advanced Life Sciences, Japan , and a Grant in Aid for Scientific Research (No. 24510314 ) from the Japan Society for the Promotion of Science (JSPS) to SA.

PY - 2013

Y1 - 2013

N2 - Three new cleistanthane diterpenes named tomocinon (1), tomocinol A (2), and tomocinol B (3), were isolated from the EtOAc extract of the seed of Caesalpinia sappan. Their structures were determined by extensive NMR spectroscopic analysis. The absolute stereochemistry of tomocinon (1) has been established by CD spectroscopic analysis. Cleistanthane diterpenes (1-3) represents the novel class of antiausterity agents having preferential cytotoxicity against PANC-1 human pancreatic cancer cell line under nutrient deprived condition with PC50 value of 34.7 μM, 42.4 μM and 39.4 μM, respectively.

AB - Three new cleistanthane diterpenes named tomocinon (1), tomocinol A (2), and tomocinol B (3), were isolated from the EtOAc extract of the seed of Caesalpinia sappan. Their structures were determined by extensive NMR spectroscopic analysis. The absolute stereochemistry of tomocinon (1) has been established by CD spectroscopic analysis. Cleistanthane diterpenes (1-3) represents the novel class of antiausterity agents having preferential cytotoxicity against PANC-1 human pancreatic cancer cell line under nutrient deprived condition with PC50 value of 34.7 μM, 42.4 μM and 39.4 μM, respectively.

KW - Antiausterity strategy

KW - Anticancer drug discovery

KW - Caesalpinia sappan

KW - Cleistanthane diterpene

KW - Nutrient starvation

KW - PANC-1

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U2 - 10.1016/j.fitote.2013.08.018

DO - 10.1016/j.fitote.2013.08.018

M3 - 学術論文

C2 - 24001712

AN - SCOPUS:84884634050

SN - 0367-326X

VL - 91

SP - 148

EP - 153

JO - Fitoterapia

JF - Fitoterapia

ER -

Cleistanthane diterpenes from the seed of Caesalpinia sappan and their antiausterity activity against PANC-1 human pancreatic cancer cell line

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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