Chemotherapy-induced multiple vertebral compression fractures in a boy with acute lymphoblastic leukemia

Toshio Kakihara; Akihiro Watanabe; Chihaya Imai; Hiromitsu Hotta; Atsushi Tanaka; Makoto Uchiyama

doi:10.1046/j.1442-200X.2002.01619.x

Chemotherapy-induced multiple vertebral compression fractures in a boy with acute lymphoblastic leukemia

Toshio Kakihara^*, Akihiro Watanabe, Chihaya Imai, Hiromitsu Hotta, Atsushi Tanaka, Makoto Uchiyama

^*この論文の責任著者

小児科学講座

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2 被引用数 (Scopus)

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Skeletal abnormalities have been encountered in children with leukemia and survivors of leukemia. Osteopenia and fractures have been frequently observed in subgroups of leukemia, which revealed CD10-positive phenotype and low leukocyte count at diagnosis. Therapy, such as chemotherapy and radiation, contributes to the progression of osteoporosis. However, severe bone fracture after initiation of chemotherapy is rare. We here report a rare case, where the patient showed severe vertebral fractures after remission induction chemotherapy. The clinical course with administration of calcium, vitamin D (1 α (OH) D₃) and calcitonin is also shown.

本文言語	英語
ページ（範囲）	683-685
ページ数	3
ジャーナル	Pediatrics International
巻	44
号	6
DOI	https://doi.org/10.1046/j.1442-200X.2002.01619.x
出版ステータス	出版済み - 2002

ASJC Scopus 主題領域

小児科学、周産期医学および子どもの健康

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10.1046/j.1442-200X.2002.01619.x

引用スタイル

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title = "Chemotherapy-induced multiple vertebral compression fractures in a boy with acute lymphoblastic leukemia",

abstract = "Skeletal abnormalities have been encountered in children with leukemia and survivors of leukemia. Osteopenia and fractures have been frequently observed in subgroups of leukemia, which revealed CD10-positive phenotype and low leukocyte count at diagnosis. Therapy, such as chemotherapy and radiation, contributes to the progression of osteoporosis. However, severe bone fracture after initiation of chemotherapy is rare. We here report a rare case, where the patient showed severe vertebral fractures after remission induction chemotherapy. The clinical course with administration of calcium, vitamin D (1 α (OH) D3) and calcitonin is also shown.",

keywords = "Bone fracture, Chemotherapy, Leukemia, Osteoporosis",

author = "Toshio Kakihara and Akihiro Watanabe and Chihaya Imai and Hiromitsu Hotta and Atsushi Tanaka and Makoto Uchiyama",

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T1 - Chemotherapy-induced multiple vertebral compression fractures in a boy with acute lymphoblastic leukemia

AU - Kakihara, Toshio

AU - Watanabe, Akihiro

AU - Imai, Chihaya

AU - Hotta, Hiromitsu

AU - Tanaka, Atsushi

AU - Uchiyama, Makoto

PY - 2002

Y1 - 2002

N2 - Skeletal abnormalities have been encountered in children with leukemia and survivors of leukemia. Osteopenia and fractures have been frequently observed in subgroups of leukemia, which revealed CD10-positive phenotype and low leukocyte count at diagnosis. Therapy, such as chemotherapy and radiation, contributes to the progression of osteoporosis. However, severe bone fracture after initiation of chemotherapy is rare. We here report a rare case, where the patient showed severe vertebral fractures after remission induction chemotherapy. The clinical course with administration of calcium, vitamin D (1 α (OH) D3) and calcitonin is also shown.

AB - Skeletal abnormalities have been encountered in children with leukemia and survivors of leukemia. Osteopenia and fractures have been frequently observed in subgroups of leukemia, which revealed CD10-positive phenotype and low leukocyte count at diagnosis. Therapy, such as chemotherapy and radiation, contributes to the progression of osteoporosis. However, severe bone fracture after initiation of chemotherapy is rare. We here report a rare case, where the patient showed severe vertebral fractures after remission induction chemotherapy. The clinical course with administration of calcium, vitamin D (1 α (OH) D3) and calcitonin is also shown.

KW - Bone fracture

KW - Chemotherapy

KW - Leukemia

KW - Osteoporosis

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U2 - 10.1046/j.1442-200X.2002.01619.x

DO - 10.1046/j.1442-200X.2002.01619.x

M3 - 学術論文

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AN - SCOPUS:0036434442

SN - 1328-8067

VL - 44

SP - 683

EP - 685

JO - Pediatrics International

JF - Pediatrics International

IS - 6

ER -

Chemotherapy-induced multiple vertebral compression fractures in a boy with acute lymphoblastic leukemia

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