Chemotherapy-induced multiple vertebral compression fractures in a boy with acute lymphoblastic leukemia

Toshio Kakihara; Akihiro Watanabe; Chihaya Imai; Hiromitsu Hotta; Atsushi Tanaka; Makoto Uchiyama

doi:10.1046/j.1442-200X.2002.01619.x

Chemotherapy-induced multiple vertebral compression fractures in a boy with acute lymphoblastic leukemia

Toshio Kakihara^*, Akihiro Watanabe, Chihaya Imai, Hiromitsu Hotta, Atsushi Tanaka, Makoto Uchiyama

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Skeletal abnormalities have been encountered in children with leukemia and survivors of leukemia. Osteopenia and fractures have been frequently observed in subgroups of leukemia, which revealed CD10-positive phenotype and low leukocyte count at diagnosis. Therapy, such as chemotherapy and radiation, contributes to the progression of osteoporosis. However, severe bone fracture after initiation of chemotherapy is rare. We here report a rare case, where the patient showed severe vertebral fractures after remission induction chemotherapy. The clinical course with administration of calcium, vitamin D (1 α (OH) D₃) and calcitonin is also shown.

Original language	English
Pages (from-to)	683-685
Number of pages	3
Journal	Pediatrics International
Volume	44
Issue number	6
DOIs	https://doi.org/10.1046/j.1442-200X.2002.01619.x
State	Published - 2002

Keywords

Bone fracture
Chemotherapy
Leukemia
Osteoporosis

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1046/j.1442-200X.2002.01619.x

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title = "Chemotherapy-induced multiple vertebral compression fractures in a boy with acute lymphoblastic leukemia",

abstract = "Skeletal abnormalities have been encountered in children with leukemia and survivors of leukemia. Osteopenia and fractures have been frequently observed in subgroups of leukemia, which revealed CD10-positive phenotype and low leukocyte count at diagnosis. Therapy, such as chemotherapy and radiation, contributes to the progression of osteoporosis. However, severe bone fracture after initiation of chemotherapy is rare. We here report a rare case, where the patient showed severe vertebral fractures after remission induction chemotherapy. The clinical course with administration of calcium, vitamin D (1 α (OH) D3) and calcitonin is also shown.",

keywords = "Bone fracture, Chemotherapy, Leukemia, Osteoporosis",

author = "Toshio Kakihara and Akihiro Watanabe and Chihaya Imai and Hiromitsu Hotta and Atsushi Tanaka and Makoto Uchiyama",

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T1 - Chemotherapy-induced multiple vertebral compression fractures in a boy with acute lymphoblastic leukemia

AU - Kakihara, Toshio

AU - Watanabe, Akihiro

AU - Imai, Chihaya

AU - Hotta, Hiromitsu

AU - Tanaka, Atsushi

AU - Uchiyama, Makoto

PY - 2002

Y1 - 2002

N2 - Skeletal abnormalities have been encountered in children with leukemia and survivors of leukemia. Osteopenia and fractures have been frequently observed in subgroups of leukemia, which revealed CD10-positive phenotype and low leukocyte count at diagnosis. Therapy, such as chemotherapy and radiation, contributes to the progression of osteoporosis. However, severe bone fracture after initiation of chemotherapy is rare. We here report a rare case, where the patient showed severe vertebral fractures after remission induction chemotherapy. The clinical course with administration of calcium, vitamin D (1 α (OH) D3) and calcitonin is also shown.

AB - Skeletal abnormalities have been encountered in children with leukemia and survivors of leukemia. Osteopenia and fractures have been frequently observed in subgroups of leukemia, which revealed CD10-positive phenotype and low leukocyte count at diagnosis. Therapy, such as chemotherapy and radiation, contributes to the progression of osteoporosis. However, severe bone fracture after initiation of chemotherapy is rare. We here report a rare case, where the patient showed severe vertebral fractures after remission induction chemotherapy. The clinical course with administration of calcium, vitamin D (1 α (OH) D3) and calcitonin is also shown.

KW - Bone fracture

KW - Chemotherapy

KW - Leukemia

KW - Osteoporosis

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U2 - 10.1046/j.1442-200X.2002.01619.x

DO - 10.1046/j.1442-200X.2002.01619.x

M3 - 学術論文

C2 - 12421271

AN - SCOPUS:0036434442

SN - 1328-8067

VL - 44

SP - 683

EP - 685

JO - Pediatrics International

JF - Pediatrics International

IS - 6

ER -

Chemotherapy-induced multiple vertebral compression fractures in a boy with acute lymphoblastic leukemia

Abstract

Keywords

ASJC Scopus subject areas

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