Chemical constituents of Thai Piper ribesoides and their antiausterity activities against the PANC-1 human pancreatic cancer cell line

Sijia Sun; Ashraf M. Omar; Min Jo Kim; Nguyen Duy Phan; Yaowared Chulikhit; Suresh Awale

doi:10.1016/j.fitote.2021.104901

Chemical constituents of Thai Piper ribesoides and their antiausterity activities against the PANC-1 human pancreatic cancer cell line

Sijia Sun, Ashraf M. Omar, Min Jo Kim, Nguyen Duy Phan, Yaowared Chulikhit, Suresh Awale^*

^*この論文の責任著者

和漢医薬学総合研究所研究開発部門資源開発分野（天然物創薬学領域）

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

抄録

A methanolic extract of Thai Piper ribesoides showed preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition, with a PC₅₀ value of 24 μg/mL. Phytochemical investigation of this bio-active extract led to the isolation of six compounds (1–6), including two new polyoxygenated cyclohexane derivatives, named ribesoidones A and B (1 and 2). The structural elucidation of the new compounds was achieved by a combination of HREIMS, NMR, and circular dichroism spectroscopic analyses. Isolated compounds were tested for their antiausterity activity against PANC-1 human pancreatic cancer cell line. Among these, compounds 1, 3, and 4 displayed potent preferential cytotoxic activity with PC₅₀ values of 5.5–7.2 μM. Ribesoidone A (1) was also found to inhibit PANC-1 colony formation under normal nutrient-rich conditions.

本文言語	英語
論文番号	104901
ジャーナル	Fitoterapia
巻	151
DOI	https://doi.org/10.1016/j.fitote.2021.104901
出版ステータス	出版済み - 2021/06

ASJC Scopus 主題領域

薬理学
創薬

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10.1016/j.fitote.2021.104901

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title = "Chemical constituents of Thai Piper ribesoides and their antiausterity activities against the PANC-1 human pancreatic cancer cell line",

abstract = "A methanolic extract of Thai Piper ribesoides showed preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition, with a PC50 value of 24 μg/mL. Phytochemical investigation of this bio-active extract led to the isolation of six compounds (1–6), including two new polyoxygenated cyclohexane derivatives, named ribesoidones A and B (1 and 2). The structural elucidation of the new compounds was achieved by a combination of HREIMS, NMR, and circular dichroism spectroscopic analyses. Isolated compounds were tested for their antiausterity activity against PANC-1 human pancreatic cancer cell line. Among these, compounds 1, 3, and 4 displayed potent preferential cytotoxic activity with PC50 values of 5.5–7.2 μM. Ribesoidone A (1) was also found to inhibit PANC-1 colony formation under normal nutrient-rich conditions.",

keywords = "Cyclohexanones, PANC-1, Piper ribesoides, Preferential cytotoxicity",

author = "Sijia Sun and Omar, {Ashraf M.} and Kim, {Min Jo} and Phan, {Nguyen Duy} and Yaowared Chulikhit and Suresh Awale",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = jun,

doi = "10.1016/j.fitote.2021.104901",

language = "英語",

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T1 - Chemical constituents of Thai Piper ribesoides and their antiausterity activities against the PANC-1 human pancreatic cancer cell line

AU - Sun, Sijia

AU - Omar, Ashraf M.

AU - Kim, Min Jo

AU - Phan, Nguyen Duy

AU - Chulikhit, Yaowared

AU - Awale, Suresh

PY - 2021/6

Y1 - 2021/6

N2 - A methanolic extract of Thai Piper ribesoides showed preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition, with a PC50 value of 24 μg/mL. Phytochemical investigation of this bio-active extract led to the isolation of six compounds (1–6), including two new polyoxygenated cyclohexane derivatives, named ribesoidones A and B (1 and 2). The structural elucidation of the new compounds was achieved by a combination of HREIMS, NMR, and circular dichroism spectroscopic analyses. Isolated compounds were tested for their antiausterity activity against PANC-1 human pancreatic cancer cell line. Among these, compounds 1, 3, and 4 displayed potent preferential cytotoxic activity with PC50 values of 5.5–7.2 μM. Ribesoidone A (1) was also found to inhibit PANC-1 colony formation under normal nutrient-rich conditions.

AB - A methanolic extract of Thai Piper ribesoides showed preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition, with a PC50 value of 24 μg/mL. Phytochemical investigation of this bio-active extract led to the isolation of six compounds (1–6), including two new polyoxygenated cyclohexane derivatives, named ribesoidones A and B (1 and 2). The structural elucidation of the new compounds was achieved by a combination of HREIMS, NMR, and circular dichroism spectroscopic analyses. Isolated compounds were tested for their antiausterity activity against PANC-1 human pancreatic cancer cell line. Among these, compounds 1, 3, and 4 displayed potent preferential cytotoxic activity with PC50 values of 5.5–7.2 μM. Ribesoidone A (1) was also found to inhibit PANC-1 colony formation under normal nutrient-rich conditions.

KW - Cyclohexanones

KW - PANC-1

KW - Piper ribesoides

KW - Preferential cytotoxicity

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AN - SCOPUS:85103710232

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JO - Fitoterapia

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