Chemical constituents of Thai Piper ribesoides and their antiausterity activities against the PANC-1 human pancreatic cancer cell line

Sijia Sun; Ashraf M. Omar; Min Jo Kim; Nguyen Duy Phan; Yaowared Chulikhit; Suresh Awale

doi:10.1016/j.fitote.2021.104901

Chemical constituents of Thai Piper ribesoides and their antiausterity activities against the PANC-1 human pancreatic cancer cell line

Sijia Sun, Ashraf M. Omar, Min Jo Kim, Nguyen Duy Phan, Yaowared Chulikhit, Suresh Awale^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A methanolic extract of Thai Piper ribesoides showed preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition, with a PC₅₀ value of 24 μg/mL. Phytochemical investigation of this bio-active extract led to the isolation of six compounds (1–6), including two new polyoxygenated cyclohexane derivatives, named ribesoidones A and B (1 and 2). The structural elucidation of the new compounds was achieved by a combination of HREIMS, NMR, and circular dichroism spectroscopic analyses. Isolated compounds were tested for their antiausterity activity against PANC-1 human pancreatic cancer cell line. Among these, compounds 1, 3, and 4 displayed potent preferential cytotoxic activity with PC₅₀ values of 5.5–7.2 μM. Ribesoidone A (1) was also found to inhibit PANC-1 colony formation under normal nutrient-rich conditions.

Original language	English
Article number	104901
Journal	Fitoterapia
Volume	151
DOIs	https://doi.org/10.1016/j.fitote.2021.104901
State	Published - 2021/06

Keywords

Cyclohexanones
PANC-1
Piper ribesoides
Preferential cytotoxicity

ASJC Scopus subject areas

Pharmacology
Drug Discovery

Access to Document

10.1016/j.fitote.2021.104901

Cite this

@article{06f83cfa849449bbbb24b5b80609cae1,

title = "Chemical constituents of Thai Piper ribesoides and their antiausterity activities against the PANC-1 human pancreatic cancer cell line",

abstract = "A methanolic extract of Thai Piper ribesoides showed preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition, with a PC50 value of 24 μg/mL. Phytochemical investigation of this bio-active extract led to the isolation of six compounds (1–6), including two new polyoxygenated cyclohexane derivatives, named ribesoidones A and B (1 and 2). The structural elucidation of the new compounds was achieved by a combination of HREIMS, NMR, and circular dichroism spectroscopic analyses. Isolated compounds were tested for their antiausterity activity against PANC-1 human pancreatic cancer cell line. Among these, compounds 1, 3, and 4 displayed potent preferential cytotoxic activity with PC50 values of 5.5–7.2 μM. Ribesoidone A (1) was also found to inhibit PANC-1 colony formation under normal nutrient-rich conditions.",

keywords = "Cyclohexanones, PANC-1, Piper ribesoides, Preferential cytotoxicity",

author = "Sijia Sun and Omar, {Ashraf M.} and Kim, {Min Jo} and Phan, {Nguyen Duy} and Yaowared Chulikhit and Suresh Awale",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = jun,

doi = "10.1016/j.fitote.2021.104901",

language = "英語",

volume = "151",

journal = "Fitoterapia",

issn = "0367-326X",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Chemical constituents of Thai Piper ribesoides and their antiausterity activities against the PANC-1 human pancreatic cancer cell line

AU - Sun, Sijia

AU - Omar, Ashraf M.

AU - Kim, Min Jo

AU - Phan, Nguyen Duy

AU - Chulikhit, Yaowared

AU - Awale, Suresh

PY - 2021/6

Y1 - 2021/6

N2 - A methanolic extract of Thai Piper ribesoides showed preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition, with a PC50 value of 24 μg/mL. Phytochemical investigation of this bio-active extract led to the isolation of six compounds (1–6), including two new polyoxygenated cyclohexane derivatives, named ribesoidones A and B (1 and 2). The structural elucidation of the new compounds was achieved by a combination of HREIMS, NMR, and circular dichroism spectroscopic analyses. Isolated compounds were tested for their antiausterity activity against PANC-1 human pancreatic cancer cell line. Among these, compounds 1, 3, and 4 displayed potent preferential cytotoxic activity with PC50 values of 5.5–7.2 μM. Ribesoidone A (1) was also found to inhibit PANC-1 colony formation under normal nutrient-rich conditions.

AB - A methanolic extract of Thai Piper ribesoides showed preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition, with a PC50 value of 24 μg/mL. Phytochemical investigation of this bio-active extract led to the isolation of six compounds (1–6), including two new polyoxygenated cyclohexane derivatives, named ribesoidones A and B (1 and 2). The structural elucidation of the new compounds was achieved by a combination of HREIMS, NMR, and circular dichroism spectroscopic analyses. Isolated compounds were tested for their antiausterity activity against PANC-1 human pancreatic cancer cell line. Among these, compounds 1, 3, and 4 displayed potent preferential cytotoxic activity with PC50 values of 5.5–7.2 μM. Ribesoidone A (1) was also found to inhibit PANC-1 colony formation under normal nutrient-rich conditions.

KW - Cyclohexanones

KW - PANC-1

KW - Piper ribesoides

KW - Preferential cytotoxicity

UR - http://www.scopus.com/inward/record.url?scp=85103710232&partnerID=8YFLogxK

U2 - 10.1016/j.fitote.2021.104901

DO - 10.1016/j.fitote.2021.104901

M3 - 学術論文

C2 - 33794305

AN - SCOPUS:85103710232

SN - 0367-326X

VL - 151

JO - Fitoterapia

JF - Fitoterapia

M1 - 104901

ER -

Chemical constituents of Thai Piper ribesoides and their antiausterity activities against the PANC-1 human pancreatic cancer cell line

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this