抄録
3,4,5-Trihydroxypiperidines belong to the family of 1,5-dideoxy-1,5-iminosugar natural products and are structural analogues of pentose monosaccharides in the pyranose form. The biological activities of these apparently structurally simple molecules and their N- and O-alkylated and -arylated derivatives are no less remarkable than their C-6 hydroxymethyl counterparts of the hexoses (such as 1-deoxynojirimycin, DNJ). Their biological profiles indicate that the hydroxymethyl branch is crucial to neither potency nor selectivity, with O-alkylation demonstrated to produce exquisite selectivity extending beyond glycosidase inhibition, to immunosuppressant and antibacterial activities.
本文言語 | 英語 |
---|---|
ページ(範囲) | 1171-1197 |
ページ数 | 27 |
ジャーナル | Chemical Biology and Drug Design |
巻 | 92 |
号 | 1 |
DOI | |
出版ステータス | 出版済み - 2018/07 |
ASJC Scopus 主題領域
- 生化学
- 分子医療
- 薬理学
- 創薬
- 有機化学