Biological activities of 3,4,5-trihydroxypiperidines and their N- and O-derivatives

Kate Prichard, David Campkin, Nicholas O'Brien, Atsushi Kato, George W.J. Fleet, Michela I. Simone*

*この論文の責任著者

研究成果: ジャーナルへの寄稿総説査読

32 被引用数 (Scopus)

抄録

3,4,5-Trihydroxypiperidines belong to the family of 1,5-dideoxy-1,5-iminosugar natural products and are structural analogues of pentose monosaccharides in the pyranose form. The biological activities of these apparently structurally simple molecules and their N- and O-alkylated and -arylated derivatives are no less remarkable than their C-6 hydroxymethyl counterparts of the hexoses (such as 1-deoxynojirimycin, DNJ). Their biological profiles indicate that the hydroxymethyl branch is crucial to neither potency nor selectivity, with O-alkylation demonstrated to produce exquisite selectivity extending beyond glycosidase inhibition, to immunosuppressant and antibacterial activities.

本文言語英語
ページ(範囲)1171-1197
ページ数27
ジャーナルChemical Biology and Drug Design
92
1
DOI
出版ステータス出版済み - 2018/07

ASJC Scopus 主題領域

  • 生化学
  • 分子医療
  • 薬理学
  • 創薬
  • 有機化学

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