Artificial nucleosides possessing metal binding sites at the 3′- and 5′-positions of the deoxyribose moieties

Jun ya Chiba, Kentaro Tanaka, Yukinori Ohshiro, Ryosuke Miyake, Shuichi Hiraoka, Motoo Shiro, Mitsuhiko Shionoya*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

17 被引用数 (Scopus)

抄録

This paper describes a convenient synthetic procedure for nucleoside mimics, 1-6, in which the 3′,5′-hydroxy groups of natural 2′-deoxythymidine or 2′-deoxyadenosine are replaced by thiol, amine, or alkylthiol groups. Such nucleosides would be built up into a single DNA strand with cooperative participation of metal coordination, where internucleoside linkages are replaced by metal complexation motifs. The X-ray crystal structure and complexation behaviors of 3′,5′-dithiothymidine, 1, with AuI are also reported.

本文言語英語
ページ(範囲)331-338
ページ数8
ジャーナルJournal of Organic Chemistry
68
2
DOI
出版ステータス出版済み - 2003/01/24

ASJC Scopus 主題領域

  • 有機化学

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