Artificial macrosphelides as a novel apoptosis-inducing compound

Yuji Matsuya; Hideo Nemoto

doi:10.3987/REV-09-660

Artificial macrosphelides as a novel apoptosis-inducing compound

Yuji Matsuya^*, Hideo Nemoto

^*この論文の責任著者

薬品製造学研究室

研究成果: ジャーナルへの寄稿 › 総説 › 査読

12 被引用数 (Scopus)

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Natural 16-membered macrolide compounds, macrosphelides, have recently been disclosed to exert an apoptosis-inducing effect against human lymphoma U937 cells. In this review, molecular design, syntheses, and biological evaluation of artificial macrosphelides are surveyed, focusing on their apoptosis-inducing activity.

本文言語	英語
ページ（範囲）	57-66
ページ数	10
ジャーナル	Heterocycles
巻	81
号	1
DOI	https://doi.org/10.3987/REV-09-660
出版ステータス	出版済み - 2010/01/01

ASJC Scopus 主題領域

分析化学
薬理学
有機化学

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10.3987/REV-09-660

引用スタイル

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abstract = "Natural 16-membered macrolide compounds, macrosphelides, have recently been disclosed to exert an apoptosis-inducing effect against human lymphoma U937 cells. In this review, molecular design, syntheses, and biological evaluation of artificial macrosphelides are surveyed, focusing on their apoptosis-inducing activity.",

keywords = "Apoptosis, Epothilone, Macrosphelide, Ring-Closing Metathesis, Thiazole Side-Chain",

author = "Yuji Matsuya and Hideo Nemoto",

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AB - Natural 16-membered macrolide compounds, macrosphelides, have recently been disclosed to exert an apoptosis-inducing effect against human lymphoma U937 cells. In this review, molecular design, syntheses, and biological evaluation of artificial macrosphelides are surveyed, focusing on their apoptosis-inducing activity.

KW - Apoptosis

KW - Epothilone

KW - Macrosphelide

KW - Ring-Closing Metathesis

KW - Thiazole Side-Chain

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Artificial macrosphelides as a novel apoptosis-inducing compound

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