Artificial macrosphelides as a novel apoptosis-inducing compound

Yuji Matsuya; Hideo Nemoto

doi:10.3987/REV-09-660

Artificial macrosphelides as a novel apoptosis-inducing compound

Yuji Matsuya^*, Hideo Nemoto

^*Corresponding author for this work

Synthetic and Medicinal Chemistry

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Natural 16-membered macrolide compounds, macrosphelides, have recently been disclosed to exert an apoptosis-inducing effect against human lymphoma U937 cells. In this review, molecular design, syntheses, and biological evaluation of artificial macrosphelides are surveyed, focusing on their apoptosis-inducing activity.

Original language	English
Pages (from-to)	57-66
Number of pages	10
Journal	Heterocycles
Volume	81
Issue number	1
DOIs	https://doi.org/10.3987/REV-09-660
State	Published - 2010/01/01

Keywords

Apoptosis
Epothilone
Macrosphelide
Ring-Closing Metathesis
Thiazole Side-Chain

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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10.3987/REV-09-660

Cite this

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title = "Artificial macrosphelides as a novel apoptosis-inducing compound",

abstract = "Natural 16-membered macrolide compounds, macrosphelides, have recently been disclosed to exert an apoptosis-inducing effect against human lymphoma U937 cells. In this review, molecular design, syntheses, and biological evaluation of artificial macrosphelides are surveyed, focusing on their apoptosis-inducing activity.",

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author = "Yuji Matsuya and Hideo Nemoto",

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AU - Nemoto, Hideo

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AB - Natural 16-membered macrolide compounds, macrosphelides, have recently been disclosed to exert an apoptosis-inducing effect against human lymphoma U937 cells. In this review, molecular design, syntheses, and biological evaluation of artificial macrosphelides are surveyed, focusing on their apoptosis-inducing activity.

KW - Apoptosis

KW - Epothilone

KW - Macrosphelide

KW - Ring-Closing Metathesis

KW - Thiazole Side-Chain

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Artificial macrosphelides as a novel apoptosis-inducing compound

Abstract

Keywords

ASJC Scopus subject areas

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