Antiviral and immunostimulating effects of lignin-carbohydrate-protein complexes from Pimpinella anisum

Jung Bum Lee, Chihiro Yamagishi, Kyoko Hayashi, Toshimitsu Hayashi*

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

91 被引用数 (Scopus)

抄録

Three antiviral and immunostimulating substances (LC1, LC2 and LC3) were isolated from a hot water extract of seeds of Pimpinella anisum by combination of anion-exchange, gel filtration and hydrophobic interaction column chromatographies. Chemical and spectroscopic analyses revealed them to be lignin-carbohydrate-protein complexes. These lignin-carbohydrate complexes (LCs) showed antiviral activities against herpes simplex virus types 1 and 2 (HSV-1 and-2), human cytomegalovirus (HCMV) and measles virus. LCs were also found to interfere with virus adsorption to the host cell surface and directly inactivate viruses. Furthermore, they enhanced nitric oxide (NO) production by inducing iNOS mRNA and protein expression in RAW 264.7 murine macrophage cells. The induced mRNA expression of cytokines including IL-1β and IL-10 was also apparent. These results suggest that the lignin-carbohydrate-protein complexes from P. anisum possessed potency as functional food ingredients against infectious diseases.

本文言語英語
ページ(範囲)459-465
ページ数7
ジャーナルBioscience, biotechnology, and biochemistry
75
3
DOI
出版ステータス出版済み - 2011

ASJC Scopus 主題領域

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学

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