Anorexigenic action of pituitary adenylate cyclase-activating polypeptide (PACAP) in the goldfish: Feeding-induced changes in the expression of mRNAs for PACAP and its receptors in the brain, and locomotor response to central injection

Kouhei Matsuda*, Keisuke Maruyama, Tohru Miura, Minoru Uchiyama, Seiji Shioda

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

52 被引用数 (Scopus)

抄録

Our recent research has indicated that intracerebroventricular (ICV) administration of pituitary adenylate cyclase-activating polypeptide (PACAP) suppresses food intake in the goldfish. We therefore examined feeding- and fasting-induced changes in the expression of mRNAs for PACAP and its receptors in the goldfish brain, and the effect of ICV administration of synthetic PACAP on locomotor activity in the goldfish. Semiquantitative analysis revealed that the expression of mRNAs for PACAP and the PAC1 receptor was significantly increased by excessive feeding (daily food supply at ≥5% of the body weight [BW]) for 7 days. ICV administration of PACAP at 20 pmol/g BW induced a significant decrease in locomotor activity during the 60-min post-treatment observation period. These results suggest that PACAP may have an anorexigenic action via hypomotility in goldfish.

本文言語英語
ページ(範囲)9-13
ページ数5
ジャーナルNeuroscience Letters
386
1
DOI
出版ステータス出版済み - 2005/09/23

ASJC Scopus 主題領域

  • 神経科学一般

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