Anorexigenic action of pituitary adenylate cyclase-activating polypeptide (PACAP) in the goldfish: Feeding-induced changes in the expression of mRNAs for PACAP and its receptors in the brain, and locomotor response to central injection

Kouhei Matsuda; Keisuke Maruyama; Tohru Miura; Minoru Uchiyama; Seiji Shioda

doi:10.1016/j.neulet.2005.05.053

Anorexigenic action of pituitary adenylate cyclase-activating polypeptide (PACAP) in the goldfish: Feeding-induced changes in the expression of mRNAs for PACAP and its receptors in the brain, and locomotor response to central injection

Kouhei Matsuda^*, Keisuke Maruyama, Tohru Miura, Minoru Uchiyama, Seiji Shioda

^*Corresponding author for this work

Department of Biology

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Our recent research has indicated that intracerebroventricular (ICV) administration of pituitary adenylate cyclase-activating polypeptide (PACAP) suppresses food intake in the goldfish. We therefore examined feeding- and fasting-induced changes in the expression of mRNAs for PACAP and its receptors in the goldfish brain, and the effect of ICV administration of synthetic PACAP on locomotor activity in the goldfish. Semiquantitative analysis revealed that the expression of mRNAs for PACAP and the PAC₁ receptor was significantly increased by excessive feeding (daily food supply at ≥5% of the body weight [BW]) for 7 days. ICV administration of PACAP at 20 pmol/g BW induced a significant decrease in locomotor activity during the 60-min post-treatment observation period. These results suggest that PACAP may have an anorexigenic action via hypomotility in goldfish.

Original language	English
Pages (from-to)	9-13
Number of pages	5
Journal	Neuroscience Letters
Volume	386
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2005.05.053
State	Published - 2005/09/23

Keywords

Anorexigenic action
Goldfish
Hypomotility
ICV injection
PAC receptor
PACAP

ASJC Scopus subject areas

General Neuroscience

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Matsuda, K., Maruyama, K., Miura, T., Uchiyama, M., & Shioda, S. (2005). Anorexigenic action of pituitary adenylate cyclase-activating polypeptide (PACAP) in the goldfish: Feeding-induced changes in the expression of mRNAs for PACAP and its receptors in the brain, and locomotor response to central injection. Neuroscience Letters, 386(1), 9-13. https://doi.org/10.1016/j.neulet.2005.05.053

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title = "Anorexigenic action of pituitary adenylate cyclase-activating polypeptide (PACAP) in the goldfish: Feeding-induced changes in the expression of mRNAs for PACAP and its receptors in the brain, and locomotor response to central injection",

abstract = "Our recent research has indicated that intracerebroventricular (ICV) administration of pituitary adenylate cyclase-activating polypeptide (PACAP) suppresses food intake in the goldfish. We therefore examined feeding- and fasting-induced changes in the expression of mRNAs for PACAP and its receptors in the goldfish brain, and the effect of ICV administration of synthetic PACAP on locomotor activity in the goldfish. Semiquantitative analysis revealed that the expression of mRNAs for PACAP and the PAC1 receptor was significantly increased by excessive feeding (daily food supply at ≥5% of the body weight [BW]) for 7 days. ICV administration of PACAP at 20 pmol/g BW induced a significant decrease in locomotor activity during the 60-min post-treatment observation period. These results suggest that PACAP may have an anorexigenic action via hypomotility in goldfish.",

keywords = "Anorexigenic action, Goldfish, Hypomotility, ICV injection, PAC receptor, PACAP",

author = "Kouhei Matsuda and Keisuke Maruyama and Tohru Miura and Minoru Uchiyama and Seiji Shioda",

note = "Funding Information: This work was supported by Grants-in Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and by a research grant from Toyama University.",

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Matsuda, K, Maruyama, K, Miura, T, Uchiyama, M & Shioda, S 2005, 'Anorexigenic action of pituitary adenylate cyclase-activating polypeptide (PACAP) in the goldfish: Feeding-induced changes in the expression of mRNAs for PACAP and its receptors in the brain, and locomotor response to central injection', Neuroscience Letters, vol. 386, no. 1, pp. 9-13. https://doi.org/10.1016/j.neulet.2005.05.053

Anorexigenic action of pituitary adenylate cyclase-activating polypeptide (PACAP) in the goldfish: Feeding-induced changes in the expression of mRNAs for PACAP and its receptors in the brain, and locomotor response to central injection. / Matsuda, Kouhei; Maruyama, Keisuke; Miura, Tohru et al.
In: Neuroscience Letters, Vol. 386, No. 1, 23.09.2005, p. 9-13.

Research output: Contribution to journal › Article › peer-review

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AU - Maruyama, Keisuke

AU - Miura, Tohru

AU - Uchiyama, Minoru

AU - Shioda, Seiji

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AB - Our recent research has indicated that intracerebroventricular (ICV) administration of pituitary adenylate cyclase-activating polypeptide (PACAP) suppresses food intake in the goldfish. We therefore examined feeding- and fasting-induced changes in the expression of mRNAs for PACAP and its receptors in the goldfish brain, and the effect of ICV administration of synthetic PACAP on locomotor activity in the goldfish. Semiquantitative analysis revealed that the expression of mRNAs for PACAP and the PAC1 receptor was significantly increased by excessive feeding (daily food supply at ≥5% of the body weight [BW]) for 7 days. ICV administration of PACAP at 20 pmol/g BW induced a significant decrease in locomotor activity during the 60-min post-treatment observation period. These results suggest that PACAP may have an anorexigenic action via hypomotility in goldfish.

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Matsuda K, Maruyama K, Miura T, Uchiyama M, Shioda S. Anorexigenic action of pituitary adenylate cyclase-activating polypeptide (PACAP) in the goldfish: Feeding-induced changes in the expression of mRNAs for PACAP and its receptors in the brain, and locomotor response to central injection. Neuroscience Letters. 2005 Sep 23;386(1):9-13. doi: 10.1016/j.neulet.2005.05.053