An antivirally active sulfated polysaccharide from Sargassum horneri (Turner) C. Agardh

Tomomi Hoshino, Toshimitsu Hayashi*, Kyoko Hayashi, Jin Hamada, Jung Bum Lee, Ushio Sankawa

*この論文の責任著者

研究成果: ジャーナルへの寄稿学術論文査読

132 被引用数 (Scopus)

抄録

A sulfated polysaccharide was isolated from the hot water extract of a brown alga, Sargassum horneri (TURNER) C. AGARDH. Fucose was detected as the main component sugar of this polysaccharide. This compound showed potent antiviral activity against herpes simplex virus type 1, human cytomegalovirus and human immunodeficiency virus type 1. Time-of-addition experiments suggested that it inhibited not only the initial stages of vital infection, such as attachment to and penetration into host cells, but also later replication stages after virus penetration.

本文言語英語
ページ(範囲)730-734
ページ数5
ジャーナルBiological and Pharmaceutical Bulletin
21
7
DOI
出版ステータス出版済み - 1998

ASJC Scopus 主題領域

  • 薬理学
  • 薬科学

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