An antivirally active sulfated polysaccharide from Sargassum horneri (Turner) C. Agardh

Tomomi Hoshino; Toshimitsu Hayashi; Kyoko Hayashi; Jin Hamada; Jung Bum Lee; Ushio Sankawa

doi:10.1248/bpb.21.730

An antivirally active sulfated polysaccharide from Sargassum horneri (Turner) C. Agardh

Tomomi Hoshino, Toshimitsu Hayashi^*, Kyoko Hayashi, Jin Hamada, Jung Bum Lee, Ushio Sankawa

^*Corresponding author for this work

Plant Resource Sciences

Research output: Contribution to journal › Article › peer-review

132 Scopus citations

Abstract

A sulfated polysaccharide was isolated from the hot water extract of a brown alga, Sargassum horneri (TURNER) C. AGARDH. Fucose was detected as the main component sugar of this polysaccharide. This compound showed potent antiviral activity against herpes simplex virus type 1, human cytomegalovirus and human immunodeficiency virus type 1. Time-of-addition experiments suggested that it inhibited not only the initial stages of vital infection, such as attachment to and penetration into host cells, but also later replication stages after virus penetration.

Original language	English
Pages (from-to)	730-734
Number of pages	5
Journal	Biological and Pharmaceutical Bulletin
Volume	21
Issue number	7
DOIs	https://doi.org/10.1248/bpb.21.730
State	Published - 1998

Keywords

Anti- HSV-1 activity
Brown alga
Fucan sulfate
Sargassum horneri
Sulfated polysaccharide

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1248/bpb.21.730

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title = "An antivirally active sulfated polysaccharide from Sargassum horneri (Turner) C. Agardh",

abstract = "A sulfated polysaccharide was isolated from the hot water extract of a brown alga, Sargassum horneri (TURNER) C. AGARDH. Fucose was detected as the main component sugar of this polysaccharide. This compound showed potent antiviral activity against herpes simplex virus type 1, human cytomegalovirus and human immunodeficiency virus type 1. Time-of-addition experiments suggested that it inhibited not only the initial stages of vital infection, such as attachment to and penetration into host cells, but also later replication stages after virus penetration.",

keywords = "Anti- HSV-1 activity, Brown alga, Fucan sulfate, Sargassum horneri, Sulfated polysaccharide",

author = "Tomomi Hoshino and Toshimitsu Hayashi and Kyoko Hayashi and Jin Hamada and Lee, {Jung Bum} and Ushio Sankawa",

year = "1998",

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T1 - An antivirally active sulfated polysaccharide from Sargassum horneri (Turner) C. Agardh

AU - Hoshino, Tomomi

AU - Hayashi, Toshimitsu

AU - Hayashi, Kyoko

AU - Hamada, Jin

AU - Lee, Jung Bum

AU - Sankawa, Ushio

PY - 1998

Y1 - 1998

N2 - A sulfated polysaccharide was isolated from the hot water extract of a brown alga, Sargassum horneri (TURNER) C. AGARDH. Fucose was detected as the main component sugar of this polysaccharide. This compound showed potent antiviral activity against herpes simplex virus type 1, human cytomegalovirus and human immunodeficiency virus type 1. Time-of-addition experiments suggested that it inhibited not only the initial stages of vital infection, such as attachment to and penetration into host cells, but also later replication stages after virus penetration.

AB - A sulfated polysaccharide was isolated from the hot water extract of a brown alga, Sargassum horneri (TURNER) C. AGARDH. Fucose was detected as the main component sugar of this polysaccharide. This compound showed potent antiviral activity against herpes simplex virus type 1, human cytomegalovirus and human immunodeficiency virus type 1. Time-of-addition experiments suggested that it inhibited not only the initial stages of vital infection, such as attachment to and penetration into host cells, but also later replication stages after virus penetration.

KW - Anti- HSV-1 activity

KW - Brown alga

KW - Fucan sulfate

KW - Sargassum horneri

KW - Sulfated polysaccharide

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AN - SCOPUS:0031826738

SN - 0918-6158

VL - 21

SP - 730

EP - 734

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 7

ER -

An antivirally active sulfated polysaccharide from Sargassum horneri (Turner) C. Agardh

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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