TY - JOUR
T1 - An α-glucoside of 1,4-dideoxy-1,4-imino-d-lyxitol with an eleven carbon side chain
AU - Kato, Atsushi
AU - Hollinshead, Jackie
AU - Yamashita, Yukiko
AU - Nakagawa, Shinpei
AU - Koike, Yuriko
AU - Adachi, Isao
AU - Yu, Chu Yi
AU - Fleet, George W.J.
AU - Nash, Robert J.
PY - 2010/12/17
Y1 - 2010/12/17
N2 - The distribution of pyrrolidine-type iminosugars with a long-side chain appears to be restricted to the relatively unrelated plant families Moraceae, Campanulaceae, and Hyacinthaceae. In a search for glycosidase inhibitors in these plant families, we isolated the 1,4-dideoxy-1,4-imino-d-lyxitol (DIL) glucoside bearing the 1,2,11-trihydroxyundec-4-ene side chain at the C-1α position from the roots of Adenophora triphylla. This iminosugar was a powerful and selective inhibitor of coffee bean α-galactosidase, with an IC 50 value of 8 μM.
AB - The distribution of pyrrolidine-type iminosugars with a long-side chain appears to be restricted to the relatively unrelated plant families Moraceae, Campanulaceae, and Hyacinthaceae. In a search for glycosidase inhibitors in these plant families, we isolated the 1,4-dideoxy-1,4-imino-d-lyxitol (DIL) glucoside bearing the 1,2,11-trihydroxyundec-4-ene side chain at the C-1α position from the roots of Adenophora triphylla. This iminosugar was a powerful and selective inhibitor of coffee bean α-galactosidase, with an IC 50 value of 8 μM.
KW - 1,4-Dideoxy-1,4-imino-d-lyxitol
KW - Glycosidase inhibitor
KW - Iminosugars
KW - Pyrrolidine alkaloids
KW - α-Galactosidase inhibitor
UR - http://www.scopus.com/inward/record.url?scp=78649495379&partnerID=8YFLogxK
U2 - 10.1016/j.phytol.2010.08.006
DO - 10.1016/j.phytol.2010.08.006
M3 - 学術論文
AN - SCOPUS:78649495379
SN - 1874-3900
VL - 3
SP - 230
EP - 233
JO - Phytochemistry Letters
JF - Phytochemistry Letters
IS - 4
ER -