Alkaloids inhibiting l-histidine decarboxylase from Sinomenium acutum

Atsushi Kato; Megumi Yasui; Natsuki Yano; Yasuyoshi Kawata; Kuniaki Moriki; Isao Adachi; Jackie Hollinshead; Robert J. Nash

doi:10.1016/j.phytol.2008.12.003

Alkaloids inhibiting l-histidine decarboxylase from Sinomenium acutum

Atsushi Kato^*, Megumi Yasui, Natsuki Yano, Yasuyoshi Kawata, Kuniaki Moriki, Isao Adachi, Jackie Hollinshead, Robert J. Nash

^*この論文の責任著者

薬剤部

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

16 被引用数 (Scopus)

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Chromatographic separation of an extract of the stems of Sinomenium acutum resulted in the isolation of two new alkaloids, 2-O-demethyl-acutumine (4), and 6-O-methyl-laudanosoline-1-O-glucoside (5), together with three known alkaloids, sinomenine (1), sinomenine N-oxide (2), and magnoflorine (3). Sinomenine was found to show good inhibitory activity toward l-histidine decarboxylase from Lactobacillus 30a with an IC₅₀ value of 969 μM but its N-oxide showed no inhibition of this enzyme. Sinomenine inhibited this enzyme in a noncompetitive manner with a K_i of 762 μM.

本文言語	英語
ページ（範囲）	77-80
ページ数	4
ジャーナル	Phytochemistry Letters
巻	2
号	2
DOI	https://doi.org/10.1016/j.phytol.2008.12.003
出版ステータス	出版済み - 2009/04/29

ASJC Scopus 主題領域

バイオテクノロジー
生化学
農業および作物学
植物科学

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10.1016/j.phytol.2008.12.003

引用スタイル

@article{e982c60739e44dd98bd52ea4eafad6b1,

title = "Alkaloids inhibiting l-histidine decarboxylase from Sinomenium acutum",

abstract = "Chromatographic separation of an extract of the stems of Sinomenium acutum resulted in the isolation of two new alkaloids, 2-O-demethyl-acutumine (4), and 6-O-methyl-laudanosoline-1-O-glucoside (5), together with three known alkaloids, sinomenine (1), sinomenine N-oxide (2), and magnoflorine (3). Sinomenine was found to show good inhibitory activity toward l-histidine decarboxylase from Lactobacillus 30a with an IC50 value of 969 μM but its N-oxide showed no inhibition of this enzyme. Sinomenine inhibited this enzyme in a noncompetitive manner with a Ki of 762 μM.",

keywords = "2-O-Demethyl-acutumine, 6-O-Methyl-laudanosoline-1-O-glucoside, Alkaloids, Sinomenine, Sinomenium acutum, l-Histidine decarboxylase inhibitor",

author = "Atsushi Kato and Megumi Yasui and Natsuki Yano and Yasuyoshi Kawata and Kuniaki Moriki and Isao Adachi and Jackie Hollinshead and Nash, {Robert J.}",

year = "2009",

month = apr,

day = "29",

doi = "10.1016/j.phytol.2008.12.003",

language = "英語",

volume = "2",

pages = "77--80",

journal = "Phytochemistry Letters",

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TY - JOUR

T1 - Alkaloids inhibiting l-histidine decarboxylase from Sinomenium acutum

AU - Kato, Atsushi

AU - Yasui, Megumi

AU - Yano, Natsuki

AU - Kawata, Yasuyoshi

AU - Moriki, Kuniaki

AU - Adachi, Isao

AU - Hollinshead, Jackie

AU - Nash, Robert J.

PY - 2009/4/29

Y1 - 2009/4/29

N2 - Chromatographic separation of an extract of the stems of Sinomenium acutum resulted in the isolation of two new alkaloids, 2-O-demethyl-acutumine (4), and 6-O-methyl-laudanosoline-1-O-glucoside (5), together with three known alkaloids, sinomenine (1), sinomenine N-oxide (2), and magnoflorine (3). Sinomenine was found to show good inhibitory activity toward l-histidine decarboxylase from Lactobacillus 30a with an IC50 value of 969 μM but its N-oxide showed no inhibition of this enzyme. Sinomenine inhibited this enzyme in a noncompetitive manner with a Ki of 762 μM.

AB - Chromatographic separation of an extract of the stems of Sinomenium acutum resulted in the isolation of two new alkaloids, 2-O-demethyl-acutumine (4), and 6-O-methyl-laudanosoline-1-O-glucoside (5), together with three known alkaloids, sinomenine (1), sinomenine N-oxide (2), and magnoflorine (3). Sinomenine was found to show good inhibitory activity toward l-histidine decarboxylase from Lactobacillus 30a with an IC50 value of 969 μM but its N-oxide showed no inhibition of this enzyme. Sinomenine inhibited this enzyme in a noncompetitive manner with a Ki of 762 μM.

KW - 2-O-Demethyl-acutumine

KW - 6-O-Methyl-laudanosoline-1-O-glucoside

KW - Alkaloids

KW - Sinomenine

KW - Sinomenium acutum

KW - l-Histidine decarboxylase inhibitor

UR - http://www.scopus.com/inward/record.url?scp=63249117381&partnerID=8YFLogxK

U2 - 10.1016/j.phytol.2008.12.003

DO - 10.1016/j.phytol.2008.12.003

M3 - 学術論文

AN - SCOPUS:63249117381

SN - 1874-3900

VL - 2

SP - 77

EP - 80

JO - Phytochemistry Letters

JF - Phytochemistry Letters

IS - 2

ER -

Alkaloids inhibiting l-histidine decarboxylase from Sinomenium acutum

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