Acid-Catalyzed Ring-Opening Cyclization of Spirocyclopropanes for the Construction of a 2-Arylbenzofuran Skeleton: Total Synthesis of Cuspidan B

Keyphrases

• 1,3-Cyclohexanedione 50%
• 1-benzofuran 50%
• 2,3-dihydrobenzofuran 50%
• 2-arylbenzofuran 100%
• Acid-catalyzed 100%
• Aryl 100%
• Arylbenzofuran Derivatives 50%
• Excellent Yields 50%
• First Total Synthesis 50%
• Metal-free Conditions 50%
• Ring-opening Cyclizations 100%
• Room Temperature 50%
• Spirocyclopropane 100%
• Tetrahydro-1 50%
• Total Synthesis 100%

Chemistry

• 1-Benzofuran 50%
• 2,3-dihydrobenzofuran 50%
• Ambient Reaction Temperature 50%
• cyclohexane-1,3-dione 50%
• formation 50%
• Ring Opening Reaction 100%