抄録
Acid-catalyzed ring-opening cyclization of cyclohexane-1,3-dione-2-spirocyclopropanes under metal-free conditions proceeded smoothly at room temperature to provide 2-aryl-3,5,6,7-tetrahydro-1-benzofuran-4(2H)-ones in excellent yields without the formation of 3-substituted isomers. The obtained product was converted into a 2-arylbenzofuran derivative via a synthetically useful 2-aryl-2,3-dihydrobenzofuran intermediate. Furthermore, the first total synthesis of cuspidan B was achieved by using the present method.
本文言語 | 英語 |
---|---|
論文番号 | ss-2016-c0077-op |
ページ(範囲) | 1892-1901 |
ページ数 | 10 |
ジャーナル | Synthesis |
巻 | 48 |
号 | 12 |
DOI | |
出版ステータス | 出版済み - 2016/06/16 |
ASJC Scopus 主題領域
- 触媒
- 有機化学