A comparison of electrochemical DNA probes possessing an isomeric ferrocene-diamidopyridine conjugate for SNPs detection on Au(111)

Reona Ikeda; Junya Chiba; Masahiko Inouye

doi:10.1380/ejssnt.2005.393

A comparison of electrochemical DNA probes possessing an isomeric ferrocene-diamidopyridine conjugate for SNPs detection on Au(111)

Reona Ikeda^*, Junya Chiba, Masahiko Inouye

^*この論文の責任著者

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

9 被引用数 (SciVal)

抄録

Electrochemical single nucleotide polymorphisms (SNPs) detection was investigated on gold surface modified with 16-base-pair duplex DNAs. In these duplexes, probe DNAs consisted of complementary sequences for target DNAs and a series of ferrocene-diamidopyridine conjugates as an electrochemically active moiety. Regardless of isomeric structures in the conjugates, all the DNA probes showed electrochemical discrimination between fully matched DNAs and SNPs. A detailed comparison was carried out for these probes.

本文言語	英語
ページ（範囲）	393-398
ページ数	6
ジャーナル	e-Journal of Surface Science and Nanotechnology
巻	3
DOI	https://doi.org/10.1380/ejssnt.2005.393
出版ステータス	出版済み - 2005/12/07

ASJC Scopus 主題領域

バイオテクノロジー
バイオエンジニアリング
凝縮系物理学
材料力学
表面および界面
表面、皮膜および薄膜

文献へのアクセス

10.1380/ejssnt.2005.393

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引用スタイル

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abstract = "Electrochemical single nucleotide polymorphisms (SNPs) detection was investigated on gold surface modified with 16-base-pair duplex DNAs. In these duplexes, probe DNAs consisted of complementary sequences for target DNAs and a series of ferrocene-diamidopyridine conjugates as an electrochemically active moiety. Regardless of isomeric structures in the conjugates, all the DNA probes showed electrochemical discrimination between fully matched DNAs and SNPs. A detailed comparison was carried out for these probes.",

keywords = "Electrochemical methods, Ferrocene, Gold, Single nucleotide polymorphism",

author = "Reona Ikeda and Junya Chiba and Masahiko Inouye",

year = "2005",

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AU - Ikeda, Reona

AU - Chiba, Junya

AU - Inouye, Masahiko

PY - 2005/12/7

Y1 - 2005/12/7

N2 - Electrochemical single nucleotide polymorphisms (SNPs) detection was investigated on gold surface modified with 16-base-pair duplex DNAs. In these duplexes, probe DNAs consisted of complementary sequences for target DNAs and a series of ferrocene-diamidopyridine conjugates as an electrochemically active moiety. Regardless of isomeric structures in the conjugates, all the DNA probes showed electrochemical discrimination between fully matched DNAs and SNPs. A detailed comparison was carried out for these probes.

AB - Electrochemical single nucleotide polymorphisms (SNPs) detection was investigated on gold surface modified with 16-base-pair duplex DNAs. In these duplexes, probe DNAs consisted of complementary sequences for target DNAs and a series of ferrocene-diamidopyridine conjugates as an electrochemically active moiety. Regardless of isomeric structures in the conjugates, all the DNA probes showed electrochemical discrimination between fully matched DNAs and SNPs. A detailed comparison was carried out for these probes.

KW - Electrochemical methods

KW - Ferrocene

KW - Gold

KW - Single nucleotide polymorphism

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DO - 10.1380/ejssnt.2005.393

M3 - 学術論文

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JO - e-Journal of Surface Science and Nanotechnology

JF - e-Journal of Surface Science and Nanotechnology

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