A case of anti-laminin 332 mucous membrane pemphigoid manifesting as desquamative gingivitis

Sahoko Imai Maeda; Kumiko Fujiwara; Kei Tomihara; Manabu Yamazaki; Shuichi Imaue; Makoto Noguchi

doi:10.1002/osi2.1073

A case of anti-laminin 332 mucous membrane pemphigoid manifesting as desquamative gingivitis

Sahoko Imai Maeda, Kumiko Fujiwara^*, Kei Tomihara, Manabu Yamazaki, Shuichi Imaue, Makoto Noguchi

^*この論文の責任著者

歯科口腔外科学講座

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

抄録

Anti-laminin 332 mucous membrane pemphigoid (MMP) is characterized by circulating anti-laminin 332 autoantibodies, with a high risk of concurrent malignant neoplasms. We report a case of anti-laminin 332 MMP manifesting as a desquamative gingivitis. A 45-year-old woman experienced painful erythema and occasional bullous lesions on the gingiva despite good oral hygiene and plaque control. Intraoral examination revealed gingival inflammation with desquamation. Biopsy showed subepithelial cleft formation suggesting a subepidermal blister. Direct immunofluorescence revealed the deposition of IgG and IgA in the epithelium. Accordingly, we diagnosed anti-laminin 332 MMP and treated with systemic corticosteroids. The oral lesion resolved after 3 months.

本文言語	英語
ページ（範囲）	73-77
ページ数	5
ジャーナル	Oral Science International
巻	18
号	1
DOI	https://doi.org/10.1002/osi2.1073
出版ステータス	出版済み - 2021/01

ASJC Scopus 主題領域

耳鼻咽喉科学

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10.1002/osi2.1073

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title = "A case of anti-laminin 332 mucous membrane pemphigoid manifesting as desquamative gingivitis",

abstract = "Anti-laminin 332 mucous membrane pemphigoid (MMP) is characterized by circulating anti-laminin 332 autoantibodies, with a high risk of concurrent malignant neoplasms. We report a case of anti-laminin 332 MMP manifesting as a desquamative gingivitis. A 45-year-old woman experienced painful erythema and occasional bullous lesions on the gingiva despite good oral hygiene and plaque control. Intraoral examination revealed gingival inflammation with desquamation. Biopsy showed subepithelial cleft formation suggesting a subepidermal blister. Direct immunofluorescence revealed the deposition of IgG and IgA in the epithelium. Accordingly, we diagnosed anti-laminin 332 MMP and treated with systemic corticosteroids. The oral lesion resolved after 3 months.",

keywords = "Anti-laminin 332, desquamative gingivitis, direct immunofluorescence microscopy, mucous membrane pemphigoid",

author = "Maeda, {Sahoko Imai} and Kumiko Fujiwara and Kei Tomihara and Manabu Yamazaki and Shuichi Imaue and Makoto Noguchi",

note = "Publisher Copyright: {\textcopyright} 2020 Japanese Stomatological Society",

year = "2021",

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doi = "10.1002/osi2.1073",

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AU - Maeda, Sahoko Imai

AU - Fujiwara, Kumiko

AU - Tomihara, Kei

AU - Yamazaki, Manabu

AU - Imaue, Shuichi

AU - Noguchi, Makoto

PY - 2021/1

Y1 - 2021/1

N2 - Anti-laminin 332 mucous membrane pemphigoid (MMP) is characterized by circulating anti-laminin 332 autoantibodies, with a high risk of concurrent malignant neoplasms. We report a case of anti-laminin 332 MMP manifesting as a desquamative gingivitis. A 45-year-old woman experienced painful erythema and occasional bullous lesions on the gingiva despite good oral hygiene and plaque control. Intraoral examination revealed gingival inflammation with desquamation. Biopsy showed subepithelial cleft formation suggesting a subepidermal blister. Direct immunofluorescence revealed the deposition of IgG and IgA in the epithelium. Accordingly, we diagnosed anti-laminin 332 MMP and treated with systemic corticosteroids. The oral lesion resolved after 3 months.

AB - Anti-laminin 332 mucous membrane pemphigoid (MMP) is characterized by circulating anti-laminin 332 autoantibodies, with a high risk of concurrent malignant neoplasms. We report a case of anti-laminin 332 MMP manifesting as a desquamative gingivitis. A 45-year-old woman experienced painful erythema and occasional bullous lesions on the gingiva despite good oral hygiene and plaque control. Intraoral examination revealed gingival inflammation with desquamation. Biopsy showed subepithelial cleft formation suggesting a subepidermal blister. Direct immunofluorescence revealed the deposition of IgG and IgA in the epithelium. Accordingly, we diagnosed anti-laminin 332 MMP and treated with systemic corticosteroids. The oral lesion resolved after 3 months.

KW - Anti-laminin 332

KW - desquamative gingivitis

KW - direct immunofluorescence microscopy

KW - mucous membrane pemphigoid

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A case of anti-laminin 332 mucous membrane pemphigoid manifesting as desquamative gingivitis

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