A case of anti-laminin 332 mucous membrane pemphigoid manifesting as desquamative gingivitis

Sahoko Imai Maeda; Kumiko Fujiwara; Kei Tomihara; Manabu Yamazaki; Shuichi Imaue; Makoto Noguchi

doi:10.1002/osi2.1073

A case of anti-laminin 332 mucous membrane pemphigoid manifesting as desquamative gingivitis

Sahoko Imai Maeda, Kumiko Fujiwara^*, Kei Tomihara, Manabu Yamazaki, Shuichi Imaue, Makoto Noguchi

^*Corresponding author for this work

Oral and Maxillofacial Surgery

Research output: Contribution to journal › Article › peer-review

Abstract

Anti-laminin 332 mucous membrane pemphigoid (MMP) is characterized by circulating anti-laminin 332 autoantibodies, with a high risk of concurrent malignant neoplasms. We report a case of anti-laminin 332 MMP manifesting as a desquamative gingivitis. A 45-year-old woman experienced painful erythema and occasional bullous lesions on the gingiva despite good oral hygiene and plaque control. Intraoral examination revealed gingival inflammation with desquamation. Biopsy showed subepithelial cleft formation suggesting a subepidermal blister. Direct immunofluorescence revealed the deposition of IgG and IgA in the epithelium. Accordingly, we diagnosed anti-laminin 332 MMP and treated with systemic corticosteroids. The oral lesion resolved after 3 months.

Original language	English
Pages (from-to)	73-77
Number of pages	5
Journal	Oral Science International
Volume	18
Issue number	1
DOIs	https://doi.org/10.1002/osi2.1073
State	Published - 2021/01

Keywords

Anti-laminin 332
desquamative gingivitis
direct immunofluorescence microscopy
mucous membrane pemphigoid

ASJC Scopus subject areas

Otorhinolaryngology

Access to Document

10.1002/osi2.1073

Cite this

@article{9ca0726610a441c89f9df1565701b71a,

title = "A case of anti-laminin 332 mucous membrane pemphigoid manifesting as desquamative gingivitis",

abstract = "Anti-laminin 332 mucous membrane pemphigoid (MMP) is characterized by circulating anti-laminin 332 autoantibodies, with a high risk of concurrent malignant neoplasms. We report a case of anti-laminin 332 MMP manifesting as a desquamative gingivitis. A 45-year-old woman experienced painful erythema and occasional bullous lesions on the gingiva despite good oral hygiene and plaque control. Intraoral examination revealed gingival inflammation with desquamation. Biopsy showed subepithelial cleft formation suggesting a subepidermal blister. Direct immunofluorescence revealed the deposition of IgG and IgA in the epithelium. Accordingly, we diagnosed anti-laminin 332 MMP and treated with systemic corticosteroids. The oral lesion resolved after 3 months.",

keywords = "Anti-laminin 332, desquamative gingivitis, direct immunofluorescence microscopy, mucous membrane pemphigoid",

author = "Maeda, {Sahoko Imai} and Kumiko Fujiwara and Kei Tomihara and Manabu Yamazaki and Shuichi Imaue and Makoto Noguchi",

note = "Publisher Copyright: {\textcopyright} 2020 Japanese Stomatological Society",

year = "2021",

month = jan,

doi = "10.1002/osi2.1073",

language = "英語",

volume = "18",

pages = "73--77",

journal = "Oral Science International",

issn = "1348-8643",

publisher = "The Japanese Stomatological Society",

number = "1",

}

TY - JOUR

T1 - A case of anti-laminin 332 mucous membrane pemphigoid manifesting as desquamative gingivitis

AU - Maeda, Sahoko Imai

AU - Fujiwara, Kumiko

AU - Tomihara, Kei

AU - Yamazaki, Manabu

AU - Imaue, Shuichi

AU - Noguchi, Makoto

PY - 2021/1

Y1 - 2021/1

N2 - Anti-laminin 332 mucous membrane pemphigoid (MMP) is characterized by circulating anti-laminin 332 autoantibodies, with a high risk of concurrent malignant neoplasms. We report a case of anti-laminin 332 MMP manifesting as a desquamative gingivitis. A 45-year-old woman experienced painful erythema and occasional bullous lesions on the gingiva despite good oral hygiene and plaque control. Intraoral examination revealed gingival inflammation with desquamation. Biopsy showed subepithelial cleft formation suggesting a subepidermal blister. Direct immunofluorescence revealed the deposition of IgG and IgA in the epithelium. Accordingly, we diagnosed anti-laminin 332 MMP and treated with systemic corticosteroids. The oral lesion resolved after 3 months.

AB - Anti-laminin 332 mucous membrane pemphigoid (MMP) is characterized by circulating anti-laminin 332 autoantibodies, with a high risk of concurrent malignant neoplasms. We report a case of anti-laminin 332 MMP manifesting as a desquamative gingivitis. A 45-year-old woman experienced painful erythema and occasional bullous lesions on the gingiva despite good oral hygiene and plaque control. Intraoral examination revealed gingival inflammation with desquamation. Biopsy showed subepithelial cleft formation suggesting a subepidermal blister. Direct immunofluorescence revealed the deposition of IgG and IgA in the epithelium. Accordingly, we diagnosed anti-laminin 332 MMP and treated with systemic corticosteroids. The oral lesion resolved after 3 months.

KW - Anti-laminin 332

KW - desquamative gingivitis

KW - direct immunofluorescence microscopy

KW - mucous membrane pemphigoid

UR - http://www.scopus.com/inward/record.url?scp=85087215422&partnerID=8YFLogxK

U2 - 10.1002/osi2.1073

DO - 10.1002/osi2.1073

M3 - 学術論文

AN - SCOPUS:85087215422

SN - 1348-8643

VL - 18

SP - 73

EP - 77

JO - Oral Science International

JF - Oral Science International

IS - 1

ER -

A case of anti-laminin 332 mucous membrane pemphigoid manifesting as desquamative gingivitis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this