TY - JOUR
T1 - α-Galactosylceramide
T2 - Potential immunomodulatory activity and future application
AU - Hayakawa, Yoshihiro
AU - Godfrey, Dale I.
AU - Smyth, Mark J.
PY - 2004
Y1 - 2004
N2 - α-Galactosylceramide (α-GalCer), is a glycolipid which has been identified as a ligand recognized by a special group of immune T cells, known as invariant NKT cells. α-GalCer can powerfully activate invariant NKT cells to produce immunoregulatory cytokines, including interferon-γ and IL-4, and thereby exert a variety of subsequent effects on other cells in the immune system. Recent studies have revealed the mechanism of α-GalCer-induced iNKT cell-activation in immune responses to tumors and microbes, and in the suppression of autoimmune diseases. In this review, we discuss the potential immunomodulatory activity of α-GalCer and its possible future application for clinical studies in humans.
AB - α-Galactosylceramide (α-GalCer), is a glycolipid which has been identified as a ligand recognized by a special group of immune T cells, known as invariant NKT cells. α-GalCer can powerfully activate invariant NKT cells to produce immunoregulatory cytokines, including interferon-γ and IL-4, and thereby exert a variety of subsequent effects on other cells in the immune system. Recent studies have revealed the mechanism of α-GalCer-induced iNKT cell-activation in immune responses to tumors and microbes, and in the suppression of autoimmune diseases. In this review, we discuss the potential immunomodulatory activity of α-GalCer and its possible future application for clinical studies in humans.
UR - http://www.scopus.com/inward/record.url?scp=1542749378&partnerID=8YFLogxK
U2 - 10.2174/0929867043456115
DO - 10.2174/0929867043456115
M3 - 総説
C2 - 14754420
AN - SCOPUS:1542749378
SN - 0929-8673
VL - 11
SP - 241
EP - 252
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 2
ER -