α-Galactosylceramide: Potential immunomodulatory activity and future application

Yoshihiro Hayakawa; Dale I. Godfrey; Mark J. Smyth

doi:10.2174/0929867043456115

α-Galactosylceramide: Potential immunomodulatory activity and future application

Yoshihiro Hayakawa, Dale I. Godfrey, Mark J. Smyth^*

^*Corresponding author for this work

Section of Host Defences, Division of Bioscience, Institute of Natural Medicine

Research output: Contribution to journal › Review article › peer-review

70 Scopus citations

Abstract

α-Galactosylceramide (α-GalCer), is a glycolipid which has been identified as a ligand recognized by a special group of immune T cells, known as invariant NKT cells. α-GalCer can powerfully activate invariant NKT cells to produce immunoregulatory cytokines, including interferon-γ and IL-4, and thereby exert a variety of subsequent effects on other cells in the immune system. Recent studies have revealed the mechanism of α-GalCer-induced iNKT cell-activation in immune responses to tumors and microbes, and in the suppression of autoimmune diseases. In this review, we discuss the potential immunomodulatory activity of α-GalCer and its possible future application for clinical studies in humans.

Original language	English
Pages (from-to)	241-252
Number of pages	12
Journal	Current Medicinal Chemistry
Volume	11
Issue number	2
DOIs	https://doi.org/10.2174/0929867043456115
State	Published - 2004

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Drug Discovery
Organic Chemistry

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title = "α-Galactosylceramide: Potential immunomodulatory activity and future application",

abstract = "α-Galactosylceramide (α-GalCer), is a glycolipid which has been identified as a ligand recognized by a special group of immune T cells, known as invariant NKT cells. α-GalCer can powerfully activate invariant NKT cells to produce immunoregulatory cytokines, including interferon-γ and IL-4, and thereby exert a variety of subsequent effects on other cells in the immune system. Recent studies have revealed the mechanism of α-GalCer-induced iNKT cell-activation in immune responses to tumors and microbes, and in the suppression of autoimmune diseases. In this review, we discuss the potential immunomodulatory activity of α-GalCer and its possible future application for clinical studies in humans.",

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AU - Hayakawa, Yoshihiro

AU - Godfrey, Dale I.

AU - Smyth, Mark J.

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N2 - α-Galactosylceramide (α-GalCer), is a glycolipid which has been identified as a ligand recognized by a special group of immune T cells, known as invariant NKT cells. α-GalCer can powerfully activate invariant NKT cells to produce immunoregulatory cytokines, including interferon-γ and IL-4, and thereby exert a variety of subsequent effects on other cells in the immune system. Recent studies have revealed the mechanism of α-GalCer-induced iNKT cell-activation in immune responses to tumors and microbes, and in the suppression of autoimmune diseases. In this review, we discuss the potential immunomodulatory activity of α-GalCer and its possible future application for clinical studies in humans.

AB - α-Galactosylceramide (α-GalCer), is a glycolipid which has been identified as a ligand recognized by a special group of immune T cells, known as invariant NKT cells. α-GalCer can powerfully activate invariant NKT cells to produce immunoregulatory cytokines, including interferon-γ and IL-4, and thereby exert a variety of subsequent effects on other cells in the immune system. Recent studies have revealed the mechanism of α-GalCer-induced iNKT cell-activation in immune responses to tumors and microbes, and in the suppression of autoimmune diseases. In this review, we discuss the potential immunomodulatory activity of α-GalCer and its possible future application for clinical studies in humans.

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α-Galactosylceramide: Potential immunomodulatory activity and future application

Abstract

ASJC Scopus subject areas

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