慢性炎症とがんをつなぐ増殖因子受容体のオルタナティブ活性化機構の解明

Keyphrases

1. Endocytosis 54%
2. Clathrin-mediated Endocytosis 53%
3. Glioblastoma Cells 53%
4. EGFRvIII 53%
5. Non-canonical 40%
6. Melanoma 35%
7. Rational Therapy 35%
8. Dinaciclib 35%
9. Negative Feedback Regulation 35%
10. Cell Death 35%
11. Egfr 35%
12. Phosphorylation 34%
13. Epidermal Growth Factor Receptor 24%
14. Anti-melanoma 21%
15. Temozolomide 17%
16. EphA2 17%
17. S6 Kinase 1 (S6K1) 17%
18. Receptor Trafficking 17%
19. Dual-mode 17%
20. BRAF Inhibitor (BRAFi) 14%
21. MEK Inhibitor (MEKi) 14%
22. Apoptosis 14%
23. Downstream Signaling 12%
24. Ligand-free 12%
25. EGFR Variant III 10%
26. Negative Feedback Loop 8%
27. Tyrosine Phosphorylation 8%
28. ERK Pathway 8%
29. Negative Feedback 8%
30. Glioblastoma multiforme 7%
31. SB203580 7%
32. Mitogen-activated Protein Kinase 7%
33. Clathrin-mediated 7%
34. BRAF Inhibition 7%
35. Endocytic Pathway 7%
36. Melanoma Growth 7%
37. Therapeutic Efficacy 7%
38. Receptor Internalization 7%
39. Rational Drug 7%
40. Oncogene 7%
41. Intrinsic Resistance 7%
42. Ligand Binding 7%
43. Ligand Concentration 7%
44. Fluorogen-activating Protein 7%
45. Drug Combination 7%
46. Genetic Modification 7%
47. Tumor 7%
48. Cyclin-dependent Kinase 4 (CDK4) 7%
49. PH-sensitive 7%
50. Induced Apoptosis 7%
51. Myeloid Cell leukemia-1 (Mcl-1) 7%
52. EGFR Endocytosis 7%
53. Clathrin Adaptor 7%
54. Acquired Resistance 7%
55. Unifying Model 7%
56. Dileucine Motif 7%
57. P38 Mitogen-activated Protein Kinase (p38 MAPK) 7%
58. Grb2 7%
59. Stress Trigger 5%
60. Cellular Stress 5%

Biochemistry, Genetics and Molecular Biology

1. Epidermal Growth Factor Receptor 100%
2. Endocytosis 70%
3. Clathrin 40%
4. Cell Death 35%
5. MEK Inhibitor 35%
6. Gene Mutation 17%
7. Ribosomal S6 Kinase 17%
8. Oncogene 17%
9. MCL1 17%
10. Estrogen Receptor 13%
11. Mitogen-Activated Protein Kinase 13%
12. Extracellular Signal-Regulated Kinases 8%
13. Tyrosine Phosphorylation 6%
14. Product Inhibition 6%
15. Internalization 6%