Keisuke Yaku

2024

Mitochondrial Redox Status Regulates Glycogen Metabolism via Glycogen Phosphorylase Activity

Sakamoto, I., Shibuya, S., Nojiri, H., Takeno, K., Nishimune, H., Yaku, K., Nakagawa, T., Ishijima, M. & Shimizu, T., 2024/11, In: Antioxidants. 13, 11, 1421.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2023

Adipocyte NMNAT1 expression is essential for nuclear NAD⁺ biosynthesis but dispensable for regulating thermogenesis and whole-body energy metabolism

Yamaguchi, S., Kojima, D., Iqbal, T., Kosugi, S., Franczyk, M. P., Qi, N., Sasaki, Y., Yaku, K., Kaneko, K., Kinouchi, K., Itoh, H., Hayashi, K., Nakagawa, T. & Yoshino, J., 2023/09/24, In: Biochemical and Biophysical Research Communications. 674, p. 162-169 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

2 被引用数 (Scopus)

Blood levels of nicotinic acid negatively correlate with hearing ability in healthy older men

Nakagawa-Nagahama, Y., Igarashi, M., Miura, M., Kashiwabara, K., Yaku, K., Fukamizu, Y., Sato, T., Sakurai, T., Nakagawa, T., Kadowaki, T. & Yamauchi, T., 2023/02/15, In: BMC Geriatrics. 23, 1, 97.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Blood levels of nicotinic acid negatively correlate with hearing ability in healthy older men

Nakagawa-Nagahama, Y., Igarashi, M., Miura, M., Kashiwabara, K., Yaku, K., Fukamizu, Y., Sato, T., Sakurai, T., Nakagawa, T., Kadowaki, T. & Yamauchi, T., 2023/12, In: BMC Geriatrics. 23, 1, 97.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (Scopus)

Deletion of Nmnat1 in Skeletal Muscle Leads to the Reduction of NAD Levels but Has No Impact on Skeletal Muscle Morphology and Fiber Types

Karim, M., Iqbal, T., Nawaz, A., Yaku, K. & Nakagawa, T., 2023, In: Journal of Nutritional Science and Vitaminology. 69, 3, p. 184-189 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

3 被引用数 (Scopus)

Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma

Nomura, M., Ohuchi, M., Sakamoto, Y., Kudo, K., Yaku, K., Soga, T., Sugiura, Y., Morita, M., Hayashi, K., Miyahara, S., Sato, T., Yamashita, Y., Ito, S., Kikuchi, N., Sato, I., Saito, R., Yaegashi, N., Fukuhara, T., Yamada, H. & Shima, H. & 9 others, Nakayama, K. I., Hirao, A., Kawasaki, K., Arai, Y., Akamatsu, S., Tanuma, S. I., Sato, T., Nakagawa, T. & Tanuma, N., 2023/12, In: Nature Communications. 14, 1, 8095.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

7 被引用数 (Scopus)

Regional contributions of D-serine to Alzheimer’s disease pathology in male App^{NL–G–F/NL–G–F} mice

Ni, X., Inoue, R., Wu, Y., Yoshida, T., Yaku, K., Nakagawa, T., Saito, T., Saido, T. C., Takao, K. & Mori, H., 2023, In: Frontiers in Aging Neuroscience. 15, 1211067.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

3 被引用数 (Scopus)

2022

Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men

Igarashi, M., Nakagawa-nagahama, Y., Miura, M., Kashiwabara, K., Yaku, K., Sawada, M., Sekine, R., Fukamizu, Y., Sato, T., Sakurai, T., Sato, J., Ino, K., Kubota, N., Nakagawa, T., Kadowaki, T. & Yamauchi, T., 2022/05/01, In: npj Aging. 8, 1

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Food odor perception promotes systemic lipid utilization

Tsuneki, H., Sugiyama, M., Ito, T., Sato, K., Matsuda, H., Onishi, K., Yubune, K., Matsuoka, Y., Nagai, S., Yamagishi, T., Maeda, T., Honda, K., Okekawa, A., Watanabe, S., Yaku, K., Okuzaki, D., Otsubo, R., Nomoto, M., Inokuchi, K. & Nakagawa, T. & 3 others, Wada, T., Yasui, T. & Sasaoka, T., 2022/11, In: Nature Metabolism. 4, 11, p. 1514-1531 18 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

16 被引用数 (Scopus)

Food odor perception promotes systemic lipid utilization

Tsuneki, H., Sugiyama, M., Ito, T., Sato, K., Matsuda, H., Onishi, K., Yubune, K., Matsuoka, Y., Nagai, S., Yamagishi, T., Maeda, T., Honda, K., Okekawa, A., Watanabe, S., Yaku, K., Okuzaki, D., Otsubo, R., Nomoto, M., Inokuchi, K. & Nakagawa, T. & 3 others, Wada, T., Yasui, T. & Sasaoka, T., 2022/11, In: Nature Metabolism. 4, 11, p. 1514-1531

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Loss of hepatic Nmnat1 has no impact on diet-induced fatty liver disease

Iqbal, T., Nawaz, A., Karim, M., Yaku, K., Hikosaka, K., Matsumoto, M. & Nakagawa, T., 2022/12/25, In: Biochemical and Biophysical Research Communications. 636, p. 89-95 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

4 被引用数 (Scopus)

Nmnat3 deficiency in hemolytic anemia exacerbates malaria infection

Mahmood, A., Yaku, K., Hikosaka, K., Gulshan, M., Inoue, S. I., Kobayashi, F. & Nakagawa, T., 2022/12/31, In: Biochemical and Biophysical Research Communications. 637, p. 58-65 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects

Okabe, K., Yaku, K., Uchida, Y., Fukamizu, Y., Sato, T., Sakurai, T., Tobe, K. & Nakagawa, T., 2022/04/11, In: Frontiers in Nutrition. 9

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

52 被引用数 (Scopus)

2021

BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities

Yaku, K., Palikhe, S., Izumi, H., Yoshida, T., Hikosaka, K., Hayat, F., Karim, M., Iqbal, T., Nitta, Y., Sato, A., Migaud, M. E., Ishihara, K., Mori, H. & Nakagawa, T., 2021/12, In: Nature Communications. 12, 1, 6767.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

54 被引用数 (SciVal)

Simultaneous measurement of amino acid enantiomers in aged mouse brain samples by lc/ms/ms combined with derivatization using n^α-(5-fluoro-2,4-dinitrophenyl)-l-leucinamide (l-fdla)

Yamamoto, T., Yaku, K. & Nakagawa, T., 2021/01, In: Metabolites. 11, 1, p. 1-13 13 p., 57.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

12 被引用数 (Scopus)

2020

Deletion of the GAPDH gene contributes to genome stability in Saccharomyces cerevisiae

Hanasaki, M., Yaku, K., Yamauchi, M., Nakagawa, T. & Masumoto, H., 2020/12, In: Scientific Reports. 10, 1, 21146.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

5 被引用数 (SciVal)

NAD+ Metabolism Regulates Preadipocyte Differentiation by Enhancing α-Ketoglutarate-Mediated Histone H3K9 Demethylation at the PPARγ Promoter

Okabe, K., Nawaz, A., Nishida, Y., Yaku, K., Usui, I., Tobe, K. & Nakagawa, T., 2020/11/24, In: Frontiers in Cell and Developmental Biology. 8, 586179.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

26 被引用数 (Scopus)

The microRNAs miR-302b and miR-372 regulate mitochondrial metabolism via the SLC25A12 transporter, which controls MAVS-mediated antiviral innate immunity

Yasukawa, K., Kinoshita, D., Yaku, K., Nakagawa, T. & Koshiba, T., 2020/01/10, In: Journal of Biological Chemistry. 295, 2, p. 444-457 14 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

32 被引用数 (SciVal)

2019

Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases.

K, H., K, Y., K, O. & T., N., 2019, In: Nutritional Neuroscience. -, 5, p. 1-17

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Metabolism and biochemical properties of nicotinamide adenine dinucleotide (NAD) analogs, nicotinamide guanine dinucleotide (NGD) and nicotinamide hypoxanthine dinucleotide (NHD)

Yaku, K., Okabe, K., Gulshan, M., Takatsu, K., Okamoto, H. & Nakagawa, T., 2019/12/01, In: Scientific Reports. 9, 1, 13102.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

23 被引用数 (Scopus)

The microRNAs miR-302b and miR-372 regulate mitochondrial metabolism via the SLC25A12 transporter, which controls MAVS-mediated antiviral innate immunity

Kai, Y., Daisuke, K., Keisuke, Y., Takashi, N. & Takumi, K., 2019, In: Journal of Biological Chemistry. 295, 2, p. 444-457

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2018

1′-Acetoxychavicol Acetate Increases Proteasome Activity by Activating cAMP-PKA Signaling

Yaku, K., Matsui-Yuasa, I. & Kojima-Yuasa, A., 2018/02/01, In: Planta Medica. 84, 3, p. 153-159 7 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

6 被引用数 (SciVal)

Deletion of PHGDH in adipocytes improves glucose intolerance in diet-induced obese mice

Okabe, K., Usui, I., Yaku, K., Hirabayashi, Y., Tobe, K. & Nakagawa, T., 2018/09/26, In: Biochemical and Biophysical Research Communications. 504, 1, p. 309-314 6 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

11 被引用数 (Scopus)

Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice

Matsui, S., Sasaki, T., Kohno, D., Yaku, K., Inutsuka, A., Yokota-Hashimoto, H., Kikuchi, O., Suga, T., Kobayashi, M., Yamanaka, A., Harada, A., Nakagawa, T., Onaka, T. & Kitamura, T., 2018/12/01, In: Nature Communications. 9, 1, 4604.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

46 被引用数 (Scopus)

Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance

Gulshan, M., Yaku, K., Okabe, K., Mahmood, A., Sasaki, T., Yamamoto, M., Hikosaka, K., Usui, I., Kitamura, T., Tobe, K. & Nakagawa, T., 2018/08, In: Aging Cell. 17, 4, e12798.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

39 被引用数 (Scopus)

Simultaneous measurement of NAD metabolome in aged mice tissue using liquid chromatography tandem-mass spectrometry

Yaku, K., Okabe, K. & Nakagawa, T., 2018/06, In: Biomedical Chromatography. 32, 6, e4205.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

38 被引用数 (Scopus)

2017

NAD 代謝による老化制御機構

夜久圭介 & 中川崇, 2017, In: 基礎老化研究. 41, p. 23-27

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Novel role of serine racemase in anti-apoptosis and metabolism

Talukdar, G., Inoue, R., Yoshida, T., Ishimoto, T., Yaku, K., Nakagawa, T. & Mori, H., 2017/01/01, In: BBA - General Subjects. 1861, 1, p. 3378-3387 10 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

8 被引用数 (Scopus)

2016

1′-Acetoxychavicol acetate ameliorates age-related spatial memory deterioration by increasing serum ketone body production as a complementary energy source for neuronal cells

Kojima-Yuasa, A., Yamamoto, T., Yaku, K., Hirota, S., Takenaka, S., Kawabe, K. & Matsui-Yuasa, I., 2016/09/25, In: Chemico-Biological Interactions. 257, p. 101-109 9 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

Open Access

9 被引用数 (Scopus)

2013

AMPK synergizes with the combined treatment of 1′-acetoxychavicol acetate and sodium butyrate to upregulate phase II detoxifying enzyme activities

Yaku, K., Matsui-Yuasa, I., Konishi, Y. & Kojima-Yuasa, A., 2013/07, In: Molecular Nutrition and Food Research. 57, 7, p. 1198-1208 11 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

16 被引用数 (Scopus)

2012

1′-acetoxychavicol acetate inhibits adipogenesis in 3T3-L1 adipocytes and in high fat-fed rats

Ohnishi, R., Matsui-Yuasa, I., Deguchi, Y., Yaku, K., Tabuchi, M., Munakata, H., Akahoshi, Y. & Kojima-Yuasa, A., 2012, In: American Journal of Chinese Medicine. 40, 6, p. 1189-1204 16 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

23 被引用数 (Scopus)

The enhancement of phase 2 enzyme activities by sodium butyrate in normal intestinal epithelial cells is associated with Nrf2 and p53

Yaku, K., Enami, Y., Kurajyo, C., Matsui-Yuasa, I., Konishi, Y. & Kojima-Yuasa, A., 2012/11, In: Molecular and Cellular Biochemistry. 370, 1-2, p. 7-14 8 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

48 被引用数 (Scopus)

2011

1′-acetoxychavicol acetate enhances the phase II enzyme activities via the increase in intranuclear Nrf2 level and cytosolic p21 level

Yaku, K., Matsui-Yuasa, I., Azuma, H. & Kojima-Yuasa, A., 2011, In: American Journal of Chinese Medicine. 39, 4, p. 789-802 14 p.

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

13 被引用数 (Scopus)

夜久 圭介

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夜久圭介