年別の研究成果
年別の研究成果
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2024
Continuous Monitoring of Pseudopolymorphic Transition in Ezetimibe Using T1Relaxation with Time-Domain NMR
Ono, T., Okada, K., Kaga, M., Eto, H., Kumada, S., Wakui, N. & Onuki, Y., 2024, In: Chemical and Pharmaceutical Bulletin. 72, 7 July, p. 676-680 5 p.研究成果: ジャーナルへの寄稿 › 総説 › 査読
Open Access -
TGA and NMR relaxation measurement of nonmesoporous silica to investigate the amount of hydrolysis product in acetylsalicylic acid adsorbed on silica
Okada, K., Watanabe, D., Ono, T., Hayashi, Y., Kumada, S. & Onuki, Y., 2024/04/15, In: Journal of Pharmaceutical and Biomedical Analysis. 241, 115972.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
1 被引用数 (Scopus) -
Use of Time-Domain NMR for 1H T1 Relaxation Measurement and Fitting Analysis in Homogeneity Evaluation of Amorphous Solid Dispersion
Okada, K., Ono, T., Hayashi, Y., Kumada, S. & Onuki, Y., 2024/03, In: Journal of Pharmaceutical Sciences. 113, 3, p. 680-687 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
3 被引用数 (Scopus) -
2023
A Data-Driven Approach to Predicting Tablet Properties after Accelerated Test Using Raw Material Property Database and Machine Learning
Hayashi, Y., Nakano, Y., Marumo, Y., Kumada, S., Okada, K. & Onuki, Y., 2023/06/01, In: Chemical and Pharmaceutical Bulletin. 71, 6, p. 406-415 10 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access3 被引用数 (Scopus) -
Application of unsupervised and supervised learning to a material attribute database of tablets produced at two different granulation scales
Hayashi, Y., Noguchi, M., Oishi, T., Ono, T., Okada, K. & Onuki, Y., 2023/06/25, In: International Journal of Pharmaceutics. 641, 123066.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access1 被引用数 (Scopus) -
Continuous Monitoring of the Agglomeration and Sedimentation of Indomethacin Nanosuspensions Using T2 Relaxation Time with Time-Domain NMR
Ono, T., Okada, K., Tsuchiya, M., Hayashi, Y., Kumada, S. & Onuki, Y., 2023/08/01, In: Chemical and Pharmaceutical Bulletin. 71, 8, p. 665-669 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
Continuous Monitoring of the Hydration Behavior of Hydrophilic Matrix Tablets Using Time-Domain NMR
Tsuji, T., Ono, T., Taguchi, H., Leong, K. H., Hayashi, Y., Kumada, S., Okada, K. & Onuki, Y., 2023/07/01, In: Chemical and Pharmaceutical Bulletin. 71, 7, p. 576-583 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access6 被引用数 (Scopus) -
Determination of the Solid Content of Active Pharmaceutical Ingredient Powders in Suspension-Type Pharmaceutical Oral Jelly Using Time-Domain NMR
Kobayashi, R., Ono, T., Kumada, S., Okada, K. & Onuki, Y., 2023/10/01, In: Chemical and Pharmaceutical Bulletin. 71, 11, p. 838-842 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access2 被引用数 (Scopus) -
In Silico Technologies to Boost Pharmaceutical Development
Onuki, Y., 2023/06/01, In: Chemical and Pharmaceutical Bulletin. 71, 6, p. 385 1 p.研究成果: ジャーナルへの寄稿 › 編集
Open Access -
Quality Evaluation of Humidified Magnesium Oxide Tablet Formulations with Respect to Disintegration Time Prolongation
Yamamoto, Y., Ohgi, K., Onuki, Y., Fukami, T. & Koided, T., 2023/02/01, In: Chemical and Pharmaceutical Bulletin. 71, 2, p. 165-174 10 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access2 被引用数 (Scopus) -
Usefulness of Applying Partial Least Squares Regression to T2 Relaxation Curves for Predicting the Solid form Content in Binary Physical Mixtures
Chiba, Y., Okada, K., Hayashi, Y., Kumada, S. & Onuki, Y., 2023/04, In: Journal of Pharmaceutical Sciences. 112, 4, p. 1041-1051 11 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access3 被引用数 (Scopus) -
2022
Characterization of the Salt and Free Base of Active Pharmaceutical Ingredients Based on NMR Relaxometry Measured by Time Domain NMR
Chiba, Y., Okada, K., Hayashi, Y., Leong, K. H., Kumada, S. & Onuki, Y., 2022/02/01, In: Chemical and Pharmaceutical Bulletin. 70, 2, p. 162-168 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access4 被引用数 (Scopus) -
Determination of Hardness of a Pharmaceutical Oral Jelly by Using T2 Relaxation Behavior Measured by Time-Domain NMR
Tsuji, T., Kobayashi, R., Hayashi, Y., Kumada, S., Mizuguchi, M., Okada, K. & Onuki, Y., 2022/08/01, In: Chemical and Pharmaceutical Bulletin. 70, 8, p. 558-565 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access3 被引用数 (Scopus) -
Low-Field NMR to Characterize the Crystalline State of Ibuprofen Confined in Ordered or Nonordered Mesoporous Silica
Okada, K., Hayashi, Y., Tsuji, T. & Onuki, Y., 2022/08/01, In: Chemical and Pharmaceutical Bulletin. 70, 8, p. 550-557 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access4 被引用数 (Scopus) -
Study of Orally Disintegrating Tablets Using Erythritol as an Excipient Produced by Moisture-Activated Dry Granulation (MADG)
Yamada, M., Ishikawa, A., Muramatsu, S., Furuishi, T., Onuki, Y., Fukuzawa, K. & Yonemochi, E., 2022/08, In: Pharmaceuticals. 15, 8, 1004.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access4 被引用数 (Scopus) -
The Molded Tablet, a disintegrant-free orally disintegrating tablet, resists thickening solution-reduced drug dissolution
Onuki, Y., Sugiura, D., Kumada, S., Kobayashi, R., Nakamura, T., Kogawa, T., Sakai, H. & Okada, K., 2022/03, In: Journal of Drug Delivery Science and Technology. 69, 103179.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access6 被引用数 (Scopus) -
2021
Application of machine learning to a material library for modeling of relationships between material properties and tablet properties
Hayashi, Y., Nakano, Y., Marumo, Y., Kumada, S., Okada, K. & Onuki, Y., 2021/11/20, In: International Journal of Pharmaceutics. 609, 121158.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
18 被引用数 (Scopus) -
Effects of Manufacturing Process Variables on the Tablet Weight Variation of Mini-tablets Clarified by a Definitive Screening Design
Usuda, S., Masukawa, N., Leong, K. H., Okada, K. & Onuki, Y., 2021/09/01, In: Chemical and Pharmaceutical Bulletin. 69, 9, p. 896-904 9 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access7 被引用数 (Scopus) -
Incompatibility of remimazolam besylate with Ringer's acetate infusion resulting in total occlusion of an intravenous catheter
Matsuo, M., Okada, K., Onuki, Y. & Yamazaki, M., 2021/04/15, In: BMJ Case Reports. 14, 4研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access9 被引用数 (Scopus) -
Nondestructive Investigation of the Agglomeration Process for Nanosuspensions via NMR Relaxation of Water Molecules
Okada, K., Hayashi, Y., Kumada, S. & Onuki, Y., 2021/09/01, In: European Journal of Pharmaceutical Sciences. 164, 105908.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
15 被引用数 (Scopus) -
Time-domain NMR analysis for the determination of water content in pharmaceutical ingredients and wet granules
Ohgi, K., Hayashi, Y., Tsuji, T., Ito, T., Leong, K. H., Usuda, S., Kumada, S., Okada, K. & Onuki, Y., 2021/07/15, In: International Journal of Pharmaceutics. 604, 120770.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
12 被引用数 (Scopus) -
2020
A precise prediction method for the properties of API-containing tablets based on data from placebo tablets
Hayashi, Y., Shirotori, K., Kosugi, A., Kumada, S., Leong, K. H., Okada, K. & Onuki, Y., 2020/07, In: Pharmaceutics. 12, 7, p. 1-13 13 p., 601.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access8 被引用数 (Scopus) -
Characterization of Powder- and Tablet Properties of Different Direct Compaction Grades of Mannitol Using a Kohonen Self-organizing Map and a Lasso Regression Model
Kosugi, A., Leong, K. H., Tsuji, H., Hayashi, Y., Kumada, S., Okada, K. & Onuki, Y., 2020/08, In: Journal of Pharmaceutical Sciences. 109, 8, p. 2585-2593 9 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
11 被引用数 (Scopus) -
Comparison of various pharmaceutical properties of clobetasol propionate cream formulations-considering stability of mixture with moisturizer-
Yamamoto, Y., Onuki, Y., Fukami, T. & Koide, T., 2020/01/30, In: Journal of Pharmaceutical Health Care and Sciences. 6, 1, 1.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access2 被引用数 (Scopus) -
Creation of novel large dataset comprising several granulation methods and the prediction of tablet properties from critical material attributes and critical process parameters using regularized linear regression models including interaction terms
Oishi, T., Hayashi, Y., Noguchi, M., Yano, F., Kumada, S., Takayama, K., Okada, K. & Onuki, Y., 2020/03/15, In: International Journal of Pharmaceutics. 577, 119083.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
14 被引用数 (Scopus) -
Effect of different direct compaction grades of mannitol on the storage stability of tablet properties investigated using a kohonen self-organizing map and elastic net regression model
Kosugi, A., Leong, K. H., Urata, E., Hayashi, Y., Kumada, S., Okada, K. & Onuki, Y., 2020/09, In: Pharmaceutics. 12, 9, p. 1-14 14 p., 886.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access7 被引用数 (Scopus) -
Effect of disintegrants on prolongation of tablet disintegration induced by immersion in xanthan gum-containing thickening solution: Contribution of disintegrant interactions with disintegration fluids
Sugiura, D., Onuki, Y., Fujita, Y., Nakamura, A. & Harada, T., 2020/11/01, In: Chemical and Pharmaceutical Bulletin. 68, 11, p. 1055-1060 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access8 被引用数 (Scopus) -
Effect of the molecular mobility of water adsorbed by disintegrants on storage-induced hydrolytic degradation of acetylsalicylic acid incorporated into tablets under humid conditions
Ougi, K., Okada, K., Leong, K. H., Hayashi, Y., Kumada, S. & Onuki, Y., 2020/11/01, In: European Journal of Pharmaceutical Sciences. 154, 105502.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
17 被引用数 (Scopus) -
Preparation and evaluation of orally disintegrating tablets containing taste masked microparticles of acetaminophen
Ikeuchi-Takahashi, Y., Ito, S., Itokawa, A., Ota, M., Onuki, Y., Hidaka, S. & Onishi, H., 2020/01, In: Pharmazie. 75, 1, p. 2-6 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
5 被引用数 (Scopus) -
Quantitative Evaluation of the Crystallinity of Indomethacin Using 1H T2 Relaxation Behaviors Measured by Time Domain NMR
Okada, K., Hayashi, Y., Kumada, S. & Onuki, Y., 2020/08, In: Journal of Pharmaceutical Sciences. 109, 8, p. 2577-2584 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
11 被引用数 (Scopus) -
2019
1H NMR Relaxation Study to Evaluate the Crystalline State of Active Pharmaceutical Ingredients Containing Solid Dosage Forms Using Time Domain NMR
Okada, K., Hirai, D., Kumada, S., Kosugi, A., Hayashi, Y. & Onuki, Y., 2019/01, In: Journal of Pharmaceutical Sciences. 108, 1, p. 451-456 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access32 被引用数 (Scopus) -
A novel approach to evaluate amorphous-to-crystalline transformation of active pharmaceutical ingredients in solid dispersion using time-domain NMR
Okada, K., Hirai, D., Hayashi, Y., Kumada, S., Kosugi, A. & Onuki, Y., 2019, In: Chemical and Pharmaceutical Bulletin. 67, 3, p. 265-270 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access12 被引用数 (Scopus) -
A time-domain NMR study of the state of water in wet granules with different fillers and its contribution to the wet granulation process and to the characteristics of granules
Ito, T., Okada, K., Leong, K. H., Hirai, D., Hayashi, Y., Kumada, S., Kosugi, A. & Onuki, Y., 2019, In: Chemical and Pharmaceutical Bulletin. 67, 3, p. 271-276 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access12 被引用数 (Scopus) -
Chitosan complexed carboxymethylated iota-carrageenan oral insulin particles: Stability, permeability and in vivo evaluation
Sahoo, P., Leong, K. H., Nyamathulla, S., Onuki, Y., Takayama, K. & Chung, L. Y., 2019/09, In: Materials Today Communications. 20, 100557.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
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Imaging Analysis Enables Differentiation of the Distribution of Pharmaceutical Ingredients in Tacrolimus Ointments
Fujii, M. Y., Yamamoto, Y., Koide, T., Hamaguchi, M., Onuki, Y., Suzuki, N., Suzuki, T. & Fukami, T., 2019/10/01, In: Applied Spectroscopy. 73, 10, p. 1183-1192 10 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
5 被引用数 (Scopus) -
In silico predictions of tablet density using a quantitative structure–property relationship model
Hayashi, Y., Marumo, Y., Takahashi, T., Nakano, Y., Kosugi, A., Kumada, S., Hirai, D., Takayama, K. & Onuki, Y., 2019/03/10, In: International Journal of Pharmaceutics. 558, p. 351-356 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
9 被引用数 (Scopus) -
T2 relaxation study to evaluate the crystalline state of indomethacin containing solid dispersions using time-domain NMR
Okada, K., Hirai, D., Hayashi, Y., Kumada, S., Kosugi, A. & Onuki, Y., 2019, In: Chemical and Pharmaceutical Bulletin. 67, 6, p. 580-586 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access17 被引用数 (Scopus) -
The usefulness of definitive screening design for a quality by design approach as demonstrated by a pharmaceutical study of orally disintegrating tablet
Takagaki, K., Ito, T., Arai, H., Obata, Y., Takayama, K. & Onuki, Y., 2019, In: Chemical and Pharmaceutical Bulletin. 67, 10, p. 1144-1151 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access13 被引用数 (Scopus) -
Time–temperature superposition principle for the kinetic analysis of destabilization of pharmaceutical emulsions
Tsuji, T., Mochizuki, K., Okada, K., Hayashi, Y., Obata, Y., Takayama, K. & Onuki, Y., 2019/05/30, In: International Journal of Pharmaceutics. 563, p. 406-412 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
11 被引用数 (Scopus) -
2018
A comparative study of disintegration actions of various disintegrants using Kohonen's self-organizing maps
Onuki, Y., Kosugi, A., Hamaguchi, M., Marumo, Y., Kumada, S., Hirai, D., Ikeda, J. & Hayashi, Y., 2018/02, In: Journal of Drug Delivery Science and Technology. 43, p. 141-148 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
29 被引用数 (Scopus) -
Determining the influence of granule size on simulation parameters and residual shear stress distribution in tablets by combining the finite element method into the design of experiments
Hayashi, Y., Kosugi, A., Miura, T., Takayama, K. & Onuki, Y., 2018, In: Chemical and Pharmaceutical Bulletin. 66, 5, p. 541-547 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
Inhibition of gastric H+,K+-ATPase activity in vitro by dissolution media of original brand-name and generic tablets of lansoprazole, a proton pump inhibitor
Phutthatiraphap, S., Hayashi, Y., Fujii, T., Kosugi, A., Okada, K., Kadozaki, T., Ishise, T., Sakai, H. & Onuki, Y., 2018, In: Chemical and Pharmaceutical Bulletin. 66, 9, p. 896-900 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access1 被引用数 (Scopus) -
Mixtures of betamethasone butyrate propionate ointments and heparinoid oil-based cream: Physical stability evaluation
Yamamoto, Y., Hanai, A., Onuki, Y., Fujii, M., Onishi, Y., Fukami, T., Metori, K., Suzuki, N., Suzuki, T. & Koide, T., 2018/11/01, In: European Journal of Pharmaceutical Sciences. 124, p. 199-207 9 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
9 被引用数 (Scopus) -
Modeling of quantitative relationships between physicochemical properties of active pharmaceutical ingredients and tensile strength of tablets using a boosted tree
Hayashi, Y., Oishi, T., Shirotori, K., Marumo, Y., Kosugi, A., Kumada, S., Hirai, D., Takayama, K. & Onuki, Y., 2018/07/03, In: Drug Development and Industrial Pharmacy. 44, 7, p. 1090-1098 9 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access28 被引用数 (Scopus) -
MRI monitoring of the mixed state of admixtures consisting of moisturizing cream and steroid ointment during the mixing process by a revolution/rotation-type hybrid mixer
Yokokawa, M., Setoyama, H., Okada, K., Hayashi, Y., Machida, Y., Onuki, Y. & Obata, Y., 2018, In: Chemical and Pharmaceutical Bulletin. 66, 11, p. 1078-1082 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
Nondestructive Monitoring of the Dispersion State of Titanium Dioxide Nanoparticles in Concentrated Suspensions Using Magnetic Resonance Imaging
Ito, T., Kida, C., Okada, K., Ikeda, J., Otomura, K., Hayashi, Y., Obata, Y., Takayama, K. & Onuki, Y., 2018/10/09, In: Langmuir. 34, 40, p. 12093-12099 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
6 被引用数 (Scopus) -
Prediction of skin permeation of flurbiprofen from neat ester oils and their O/W emulsions
Todo, H., Tamura, M., Uchida, T., Kurumada, M., Motoki, A., Sano, T., Onuki, Y., Takayama, K. & Sugibayashi, K., 2018, In: Chemical and Pharmaceutical Bulletin. 66, 10, p. 959-966 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access2 被引用数 (Scopus) -
Strength simulation of scored tablets based on the finite element method using an extreme vertices design
Hayashi, Y., Okada, N., Takayama, K., Obata, Y. & Onuki, Y., 2018, In: Chemical and Pharmaceutical Bulletin. 66, 7, p. 727-731 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access2 被引用数 (Scopus) -
2017
Comparison of pharmaceutical properties among clobetasol propionate cream formulations: Considerations from near infrared spectra
Yamamoto, Y., Fukami, T., Onuki, Y., Metori, K., Suzuki, T. & Koide, T., 2017/11, In: Vibrational Spectroscopy. 93, p. 17-22 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
11 被引用数 (Scopus) -
Improved sustained release of antigen from immunostimulatory DNA hydrogel by electrostatic interaction with chitosan
Ishii-Mizuno, Y., Umeki, Y., Onuki, Y., Watanabe, H., Takahashi, Y., Takakura, Y. & Nishikawa, M., 2017/01/10, In: International Journal of Pharmaceutics. 516, 1-2, p. 392-400 9 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読