TY - JOUR
T1 - Nondestructive Monitoring of the Dispersion State of Titanium Dioxide Nanoparticles in Concentrated Suspensions Using Magnetic Resonance Imaging
AU - Ito, Terushi
AU - Kida, Chihiro
AU - Okada, Kotaro
AU - Ikeda, Junko
AU - Otomura, Kotaro
AU - Hayashi, Yoshihiro
AU - Obata, Yasuko
AU - Takayama, Kozo
AU - Onuki, Yoshinori
N1 - Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/10/9
Y1 - 2018/10/9
N2 - The purpose of the present study is to demonstrate the applicability of magnetic resonance imaging, especially T2 relaxation time mapping, for nondestructive monitoring of the dispersion state of nanoparticles (NPs) in concentrated suspensions. TiO2 15-nm-diameter NPs, for use in sunscreen lotion products, were examined as a test NP. First, this study investigated whether T2 is sensitive to the NP concentration. In experiments with pulsed nuclear magnetic resonance on TiO2 NP suspensions with different organic solvents (ethanol, acetone, and decamethylcyclopentasiloxane), the T2 of each solvent varied in the suspensions according to the NP concentration. This study also confirmed that T2 mapping was effective for visualizing differences in NP concentration. Subsequently, gravitational sedimentation of the test suspensions was investigated. T2 mapping exhibited better detection sensitivity to sedimentation occurring in concentrated suspensions than visual observation, as it enabled the detection of changes in NP distributions that could not be visible to the naked eye. In addition, measurements of backscattered light enabled the full understanding of the dispersion stability of the TiO2 NPs in each solvent. Finally, the present study evaluated the centrifuge sedimentation of a commercial TiO2 NP suspension. T2 mapping clearly showed the complicated sedimentation behavior induced by the centrifugation treatment. The simulated fluid flow was consistent with the particle distribution in the centrifuged sample; thus, the sedimentation was believed to have developed in accordance with the vorticity generated by the centrifugation.
AB - The purpose of the present study is to demonstrate the applicability of magnetic resonance imaging, especially T2 relaxation time mapping, for nondestructive monitoring of the dispersion state of nanoparticles (NPs) in concentrated suspensions. TiO2 15-nm-diameter NPs, for use in sunscreen lotion products, were examined as a test NP. First, this study investigated whether T2 is sensitive to the NP concentration. In experiments with pulsed nuclear magnetic resonance on TiO2 NP suspensions with different organic solvents (ethanol, acetone, and decamethylcyclopentasiloxane), the T2 of each solvent varied in the suspensions according to the NP concentration. This study also confirmed that T2 mapping was effective for visualizing differences in NP concentration. Subsequently, gravitational sedimentation of the test suspensions was investigated. T2 mapping exhibited better detection sensitivity to sedimentation occurring in concentrated suspensions than visual observation, as it enabled the detection of changes in NP distributions that could not be visible to the naked eye. In addition, measurements of backscattered light enabled the full understanding of the dispersion stability of the TiO2 NPs in each solvent. Finally, the present study evaluated the centrifuge sedimentation of a commercial TiO2 NP suspension. T2 mapping clearly showed the complicated sedimentation behavior induced by the centrifugation treatment. The simulated fluid flow was consistent with the particle distribution in the centrifuged sample; thus, the sedimentation was believed to have developed in accordance with the vorticity generated by the centrifugation.
UR - http://www.scopus.com/inward/record.url?scp=85054405016&partnerID=8YFLogxK
U2 - 10.1021/acs.langmuir.8b02410
DO - 10.1021/acs.langmuir.8b02410
M3 - 学術論文
C2 - 30217112
AN - SCOPUS:85054405016
SN - 0743-7463
VL - 34
SP - 12093
EP - 12099
JO - Langmuir
JF - Langmuir
IS - 40
ER -