年別の研究成果
年別の研究成果
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2025
A New 19(10→9)Abeo-Euphane Triterpenoid with other Terpenoid Components from Trichilia dregeana Leaves and their NO Production Inhibitory Activities in LPS-Stimulated RAW264.7 Macrophages
Mba Nguekeu, Y. M., Kodama, T., Paing Htoo, Z., Matheuda, E. G., Tsepeupon Matchide, M. G., Augustin Ngouela, S., Tene, M., Ducret Awouafack, M. & Morita, H., 2025/01, In: Chemistry and Biodiversity. 22, 1, e202401919.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
1 被引用数 (Scopus) -
A new antibacterial neo-clerodane diterpenoid and other constituents from Chasmanthera dependens Hochst. (Menispermaceae) and their chemotaxonomic significance
Ngalaha Ediah, S. H., Matheuda, E. G., Kefossang, B. A., Nguekeu, Y. M. M., Kodama, T., Hnin, S. Y. Y., Qian, Z., Awouafack, M. D., Tsopmo, A., Morita, H. & Tene, M., 2025/02, In: Biochemical Systematics and Ecology. 118, 104922.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
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Derivatives of the Clinically Used HIF Prolyl Hydroxylase Inhibitor Desidustat Are Efficient Inhibitors of Human γ-Butyrobetaine Hydroxylase
Corner, T. P., Tumber, A., Salah, E., Jabbary, M., Nakashima, Y., Schnaubelt, L. I., Basak, S., Alshref, F. M., Brewitz, L. & Schofield, C. J., 2025/05/08, In: Journal of Medicinal Chemistry. 68, 9, p. 9777-9798 22 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
Divergent total synthesis of natural products bearing isoflavone and 2-oxabicyclo[3.3.1]nonane skeleton using phloroglucinol and their application in drug discovery
Okada, T., Mizuguchi, M., Yokoyama, T., Awale, S. & Toyooka, N., 2025, (受理済み/印刷中) Advances in Heterocyclic Chemistry. Academic Press Inc., (Advances in Heterocyclic Chemistry).研究成果: 書籍の章/レポート/会議録 › 章 › 査読
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Enhanced Production of Rebaudioside D and Rebaudioside M through V155T Substitution in the Glycosyltransferase UGT91D2 from Stevia rebaudiana
Shoji, T., Tanaka, Y., Nakashima, Y., Mizohata, E., Komaki, M., Sugawara, S., Takaya, J., Yonekura-Sakakibara, K., Morita, H., Saito, K. & Hirai, T., 2025/01/22, In: Journal of Agricultural and Food Chemistry. 73, 3, p. 2019-2032 14 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
2 被引用数 (Scopus) -
Natural xanthones as modulators of the Nrf2/ARE signaling pathway and potential gastroprotective agents
Gunter, N. V., Teh, S. S., Jantan, I., Law, K. P., Morita, H. & Mah, S. H., 2025/04, In: Phytotherapy Research. 39, 4, p. 1721-1734 14 p.研究成果: ジャーナルへの寄稿 › 総説 › 査読
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Nelumbo nucifera Petals Ameliorate Depressive-like Symptom and Cognitive Deficit in Unpredictable Chronic Mild Stress Mouse Model
Maneenet, J., Chotritthirong, Y., Omar, A. M., Choonong, R., Daodee, S., Monthakantirat, O., Khamphukdee, C., Pitiporn, S., Awale, S., Matsumoto, K. & Chulikhit, Y., 2025/01, In: Nutrients. 17, 1, 94.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
New cerebrosides and ceramide with other constituents from the aerial parts of Raphidiocystis mannii Hook. f. and their cytotoxic activities
Nguekeu, Y. M. M., Fozeng, H. D. S., Chukwuma, C. I., Hnin, S. Y. Y., Hoang, N. N., Njoya, E. M., Ngouela, S. A., Tene, M., Makhafola, T. J., Morita, H. & Awouafack, M. D., 2025/03, In: Natural Medicines. 79, 2, p. 412-421 10 p., e1700472.研究成果: ジャーナルへの寄稿 › コメント/討論
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Nontargeted Metabolomics of Streptomyces Sourced from Thailand Reveals the Presence of Bioactive Metabolites
Sunghanghwa, Y., Paemanee, A., Do, K. M., Meethangdee, M., Plechatá, M., Pathom-Aree, W., Punsawad, C., Morita, H., Tangphatsornruang, S., Kamenik, Z. & Jaisi, A., 2025/03/25, In: ACS Omega. 10, 11, p. 11567-11579 13 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
The genus Pittosporum: current knowledge on traditional use, phytochemistry, and pharmacological activity
Linh, N. T. T., Van Tuyen, N., Pham, T. V., Awale, S. & Son, N. T., 2025/04, In: Phytochemistry Reviews. 24, 2, p. 2015-2058 44 p., 105292.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
3 被引用数 (SciVal) -
Toyaburgine, a Synthetic N-Biphenyl-Dihydroisoquinoline Inspired by Related N,C-Coupled Naphthylisoquinoline Alkaloids, with High In Vivo Efficacy in Preclinical Pancreatic Cancer Models
Awale, S., Maneenet, J., Phan, N. D., Nguyen, H. H., Fujii, T., Ihmels, H., Soost, D., Tajuddeen, N., Feineis, D. & Bringmann, G., 2025/04/18, In: ACS Chemical Biology. 20, 4, p. 917-929 13 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
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2024
A new 3,4-seco-isopimarane and three new isopimarane diterpenoids from Kaempferia champasakensis collected from Vietnam and their cytotoxic activities
Do, K. M., Hoshino, S., Kodama, T., Nguyen, H. M., Van Le, S., Ikumi, N., Onaka, H. & Morita, H., 2024, (受理済み/印刷中) In: Natural Medicines.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
2 被引用数 (Scopus) -
Antibacterial activity, cytotoxicity and chemotaxonomic significance of chemical constituents from Alsophila manniana Hook R.M.Tryon (Cyatheaceae) rhizomes
Tsepeupon Matchide, M. G., Sonfack Fozeng, H. D., Tchuente Tchuenmogne, M. A., Djadock Anensong, C. S., Wembe Koagne, W., Anthonissen, S., Mba Nguekeu, Y. M., Do, K. M., Lee, Y. E., Dehaen, W., Morita, H., Tene, M., Ngouela, S. A. & Awouafack, M. D., 2024/06, In: Biochemical Systematics and Ecology. 114, 104834.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
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Antibacterial activity of five Indonesian medicinal plants and the isolation of compounds from Plectranthus scutellarioides
Rakainsa, S. K., Nisa, K., Ito, T. & Morita, H., 2024/05, In: Journal of Applied Pharmaceutical Science. 14, 5, p. 185-192 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity
Wu, Y., Chen, Y., Corner, T. P., Nakashima, Y., Salah, E., Li, Z., Zhang, L., Yang, L., Tumber, A., Sun, Z., Wen, Y., Zhong, A., Yang, F., Li, X., Zhang, Z., Schofield, C. J. & Zhang, X., 2024/10/01, In: Angewandte Chemie - International Edition. 63, 40, e202410438.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access5 被引用数 (Scopus) -
Chitosan-graft-poly(lactide) nanocarriers: An efficient antioxidant delivery system for combating oxidative stress
Goshtasbi, H., Awale, S., Amini-Fazl, M. S., Fathi, M., Movafeghi, A., Barar, J. & Omidi, Y., 2024/11, In: International Journal of Biological Macromolecules. 279, 135280.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
1 被引用数 (Scopus) -
Crystallographic and Selectivity Studies on the Approved HIF Prolyl Hydroxylase Inhibitors Desidustat and Enarodustat
Corner, T. P., Salah, E., Tumber, A., Kaur, S., Nakashima, Y., Allen, M. D., Schnaubelt, L. I., Fiorini, G., Brewitz, L. & Schofield, C. J., 2024/12/16, In: ChemMedChem. 19, 24, e202400504.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access1 被引用数 (Scopus) -
Cytotoxic potential of dihydrochalcones from Eriosema glomeratum and their semi-synthetic derivatives
Tabakam, G. T., Kodama, T., Tchuenmogne, M. A. T., Hoang, N. N., Nomin-Erdene, B., Ngouela, S. A., Tene, M., Morita, H. & Awouafack, M. D., 2024, In: Natural Product Research. 38, 2, p. 186-197 12 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
3 被引用数 (Scopus) -
Droserone and dioncoquinone B, and related naphthoquinones as potent antiausterity agents against human PANC-1 pancreatic cancer cells
Maneenet, J., Tajuddeen, N., Hong Nguyen, H., Fujii, R., Kimbadi Lombe, B., Feineis, D., Awale, S. & Bringmann, G., 2024/01, In: Results in Chemistry. 7, 101352.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access3 被引用数 (Scopus) -
Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase for the Formation of Longer Alkyl-Chain Olivetolic Acid Analogs and Their Antibacterial Activities
Morita, H., 2024, In: Chemical and Pharmaceutical Bulletin. 72, 1, p. 1-10 10 p.研究成果: ジャーナルへの寄稿 › 総説 › 査読
Open Access -
Effect of Diacetylcurcumin Manganese Complex on Rotenone-Induced Oxidative Stress, Mitochondria Dysfunction, and Inflammation in the SH-SY5Y Parkinson’s Disease Cell Model
Pirunkaset, E., Boonyarat, C., Maneenet, J., Khamphukdee, C., Daodee, S., Monthakantirat, O., Awale, S., Kijjoa, A. & Chulikhit, Y., 2024/03, In: Molecules. 29, 5, 957.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access5 被引用数 (Scopus) -
Facile Synthesis of 1,2-Disubstituted Benzimidazoles as Potent Cytotoxic Agents
Bui, H. T. B., Htoo, Z. P., Hong, Q. V., Le, H. T., Tran, D. Q., Hnin, S. Y. Y., Do, K. M. & Morita, H., 2024/11, In: Chemical and Pharmaceutical Bulletin. 72, 11, p. 944-949 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access1 被引用数 (Scopus) -
Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities
Do, K. M., Hoshino, S., Kodama, T., Nguyen, H. M., Ikumi, N., Onaka, H. & Morita, H., 2024/09, In: Natural Medicines. 78, 4, p. 908-918 11 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
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Goreisan-induced modulation of fecal bile acid composition and gut microbiota in mice
Watanabe, S., Takahashi, K., Awale, S., Furusawa, Y., Tabuchi, Y., Nishidono, Y. & Tanaka, K., 2024/04, In: Traditional & Kampo Medicine. 11, 1, p. 46-53 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
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Justicidin B and related lignans from two South African Monsonia species with potent activity against HeLa cervical cancer cells
Tajuddeen, N., Muyisa, S., Maneenet, J., Nguyen, H. H., Naidoo-Maharaj, D., Maharaj, V., Awale, S. & Bringmann, G., 2024/04, In: Phytochemistry Letters. 60, p. 234-238 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
3 被引用数 (Scopus) -
New 19(10 → 9)abeo-euphane-type triterpenoids from Trichilia dregeana leaves and NO production inhibitory activities
Mba Nguekeu, Y. M., Kodama, T., Tsepeupon Matchide, M. G., Do, K. M., Nghokeng, J., Tabakam, G. T., Tsuge, K., Ngouela, S. A., Mathieu, T., Awouafack, M. D. & Morita, H., 2024/07, In: Fitoterapia. 176, 106001.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
2 被引用数 (Scopus) -
Peptide Epimerase Responsible for d-Amino Acid Introduction in Poly-γ-glutamic Acid Biosynthesis
Kato, H., Sakuta, M., Tsunoda, T., Nakashima, Y., Morita, H., Ogasawara, Y. & Dairi, T., 2024/01/08, In: Biomacromolecules. 25, 1, p. 349-354 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
2 被引用数 (Scopus) -
Solvent-free strategy for facile synthesis and cytotoxicity evaluation of benzimidazole derivatives
Bui, H. T. B., Do, K. M., Hong, Q. V., Le, H. T., Hnin, S. Y. Y., Tran, D. Q., Mai, H. V., Nguyen, T. T. T., Mai, T. T. K. & Morita, H., 2024/04/28, In: Tetrahedron. 156, 133940.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
1 被引用数 (Scopus) -
Structure-Based Catalytic Mechanism of Amaryllidaceae O-Methyltransferases
Hnin, S. Y. Y., Nakashima, Y., Kodama, T. & Morita, H., 2024/08/02, In: ACS Catalysis. 14, 15, p. 11865-11880 16 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
1 被引用数 (Scopus) -
Substrate-Dependent Alteration in the C- and O-Prenylation Specificities of Cannabis Prenyltransferase
Tanaya, R., Kodama, T., Maneenet, J., Yasuno, Y., Nakayama, A., Shinada, T., Takahashi, H., Ito, T., Morita, H., Awale, S. & Taura, F., 2024/02, In: Biological and Pharmaceutical Bulletin. 47, 2, p. 449-453 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
Substrate Flexibilities of Norbelladine Synthase and Noroxomaritidine/ Norcraugsodine Reductase for Hydroxylated and/or Methoxylated Aldehydes
Hnin, S. Y. Y., Nakashima, Y. & Morita, H., 2024, In: Chemical and Pharmaceutical Bulletin. 72, 5, p. 507-511 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access5 被引用数 (Scopus) -
Syntheses and Cytotoxicities of Quinazolinone-Based Conjugates
Le, H. T., Do, K. M., Nguyen, Q. P., Doan, C. N. M., Nguyen, N. A., Phan, T. T., Tran, X. T. C., Ha, Q. T. K., Tran, D. Q., Morita, H. & Bui, H. T. B., 2024/01/20, In: Chemical and Pharmaceutical Bulletin. 72, 1, p. 61-67 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access -
Targeting Pancreatic Cancer with Novel Nicolaioidesin C Derivatives: Molecular Mechanism, In Vitro, and In Vivo Evaluations
Yamazaki, T., Phan, N. D., Maneenet, J., Yamagishi, M., Nishikawa, Y., Okada, T., Okumura, T., Toyooka, N., Fujii, T. & Awale, S., 2024/08/22, In: Journal of Medicinal Chemistry. 67, 16, p. 14313-14328 16 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
3 被引用数 (Scopus) -
Three neo-Clerodane Diterpenoids from Tinospora cordifolia Stems and Their Arginase Inhibitory Activities
Hoang, N. N., Hoshino, S., Kodama, T., Nakashima, Y., Do, K. M., Thao, H. X., Ikumi, N., Onaka, H. & Morita, H., 2024/06, In: Chemical and Pharmaceutical Bulletin. 72, 6, p. 540-546 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access3 被引用数 (Scopus) -
Two new neo-clerodane diterpenoids from Tinospora cordifolia stems
Hoang, N. N., Hoshino, S., Kodama, T., Hoang, T. X., Onaka, H. & Morita, H., 2024/10, In: Phytochemistry Letters. 63, p. 54-59 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
1 被引用数 (Scopus) -
2023
5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5
Brewitz, L., Nakashima, Y., Piasecka, S. K., Salah, E., Fletcher, S. C., Tumber, A., Corner, T. P., Kennedy, T. J., Fiorini, G., Thalhammer, A., Christensen, K. E., Coleman, M. L. & Schofield, C. J., 2023/08/10, In: Journal of Medicinal Chemistry. 66, 15, p. 10849-10865 17 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access7 被引用数 (Scopus) -
Antidepressant-like Effect of Oroxylum indicum Seed Extract in Mice Model of Unpredictable Chronic Mild Stress
Chalermwongkul, C., Khamphukdee, C., Maneenet, J., Daodee, S., Monthakantirat, O., Boonyarat, C., Chotritthirong, Y., Awale, S., Kijjoa, A. & Chulikhit, Y., 2023/11, In: Nutrients. 15, 22, 4742.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access3 被引用数 (Scopus) -
Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes
Hoang, N. N., Kodama, T., Nakashima, Y., Do, K. M., Hnin, S. Y. Y., Lee, Y. E., Prema, Ikumi, N. & Morita, H., 2023/09, In: Natural Medicines. 77, 4, p. 891-897 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
3 被引用数 (Scopus) -
Catalytic Potential of Cannabis Prenyltransferase to Expand Cannabinoid Scaffold Diversity
Tanaya, R., Kodama, T., Lee, Y. E., Yasuno, Y., Shinada, T., Takahashi, H., Ito, T., Morita, H., Awale, S. & Taura, F., 2023/12/08, In: Organic Letters. 25, 48, p. 8601-8605 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
5 被引用数 (Scopus) -
Dioncophyllidine E: The first configurationally semi-stable, 7,3′-coupled naphthyldihydroisoquinoline alkaloid, from Ancistrocladus abbreviatus, with antiausterity activity against PANC-1 human pancreatic cancer cells
Fayez, S., Cacciatore, A., Maneenet, J., Nguyen, H. H., Tajuddeen, N., Feineis, D., Assi, L. A., Awale, S. & Bringmann, G., 2023/04/15, In: Bioorganic and Medicinal Chemistry Letters. 86, 129234.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
2 被引用数 (Scopus) -
Dryoptkirbioside, A New Fructofuranoside Glycerol, and Other Constituents from Dryopteris kirbi Hook et Grav Rhizomes
Matchide, M. G. T., Hnin, S. Y. Y., Nguekeu, Y. M. M., Matheuda, E. G., Nghokeng, J., Tabakam, G. T., Djoumbissie, R. A. D., Ngouela, S. A., Lee, Y. E., Tene, M., Morita, H. & Awouafack, M. D., 2023/09, In: Chemistry and Biodiversity. 20, 9, e202301127.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access4 被引用数 (Scopus) -
Harnessing microalgae as sustainable cellular factories for biopharmaceutical production
Goshtasbi, H., Okolodkov, Y. B., Movafeghi, A., Awale, S., Safary, A., Barar, J. & Omidi, Y., 2023/07, In: Algal Research. 74, 103237.研究成果: ジャーナルへの寄稿 › 総説 › 査読
23 被引用数 (Scopus) -
Identification of a diarylpentanoid-producing polyketide synthase in the biosynthesis of 2-(2-phenylethyl)chromones in agarwood
Morita, H., Lee, Y. E. & Shi, S. P., 2023/09, In: Natural Medicines. 77, 4, p. 667-676 10 p.研究成果: ジャーナルへの寄稿 › 総説 › 査読
Open Access4 被引用数 (Scopus) -
Multi-Target Actions of Flavonoid Derivatives from Mesua ferrea Linn Flower against Alzheimer’s disease Pathogenesis
Plekratoke, K., Waiwut, P., Yenjai, C., Monthakantirat, O., Takomthong, P., Nualkaew, N., Awale, S., Chulikhit, Y., Daodee, S., Khamphukdee, C. & Boonyarat, C., 2023/10/01, In: Biomedical Sciences and Clinical Medicine. 62, 4, p. 169-180 12 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access1 被引用数 (Scopus) -
Nicolaioidesin C: An Antiausterity Agent Shows Promising Antitumor Activity in a Pancreatic Cancer Xenograft Mouse Model
Phan, N. D., Omar, A. M., Takahashi, I., Baba, H., Okumura, T., Imura, J., Okada, T., Toyooka, N., Fujii, T. & Awale, S., 2023/06/23, In: Journal of Natural Products. 86, 6, p. 1402-1410 9 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
7 被引用数 (Scopus) -
Phenolic Derivatives with Anti-Acetylcholinesterase Inhibitory Activities from Galeola nudifolia in Vietnam
Do, K. M., Nakashima, Y., Kodama, T., Lee, Y. E., Nguyen, H. M., Ikumi, N. & Morita, H., 2023/12, In: Chemistry and Biodiversity. 20, 12, e202301482.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
1 被引用数 (Scopus) -
Phenylphenalenone-type phytoalexins in banana (Musa species): a comprehensive review for new research directions
Krishnamurthy, P., Ravikumar, M. J., Arumugam Palanivelu, S., Pothiraj, R., Suthanthiram, B., Subbaraya, U. & Morita, H., 2023/02, In: Phytochemistry Reviews. 22, 1, p. 187-210 24 p.研究成果: ジャーナルへの寄稿 › 総説 › 査読
6 被引用数 (Scopus) -
Piper longum Constituents Induce PANC-1 Human Pancreatic Cancer Cell Death under Nutrition Starvation
Fujihashi, Y., Jo Kim, M., Maneenet, J. & Awale, S., 2023/09, In: Chemistry and Biodiversity. 20, 9, e202300280.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
2 被引用数 (Scopus) -
Seco- and isopimarane diterpenoids from Kaempferia marginata rhizomes and their NO inhibition activities
Do, K. M., Kodama, T., Nguyen, H. M., Ikumi, N., Soeda, C., Shiokawa, K. I. & Morita, H., 2023/01, In: Phytochemistry. 205, 113510.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access3 被引用数 (Scopus) -
Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2
Figg, W. D., Fiorini, G., Chowdhury, R., Nakashima, Y., Tumber, A., McDonough, M. A. & Schofield, C. J., 2023/11, In: Proteins: Structure, Function and Genetics. 91, 11, p. 1510-1524 15 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access6 被引用数 (Scopus)