年別の研究成果
年別の研究成果
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2018
Functional characteristics of a renal H+/lipophilic cation antiport system in porcine LLC-PK1 cells and rats
Matsui, R., Hattori, R., Usami, Y., Koyama, M., Hirayama, Y., Matsuba, E. & Hashimoto, Y., 2018/02, In: Drug Metabolism and Pharmacokinetics. 33, 1, p. 96-102 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
1 被引用数 (Scopus) -
2017
The true distribution volume and bioavailability of mizoribine in children with chronic kidney disease
Nagai, T., Uemura, O., Kaneda, H., Ushijima, K., Ohta, K., Gotoh, Y., Satomura, K., Shimizu, M., Fujieda, M., Morooka, M., Yamada, T., Yamada, M., Wada, N. & Hashimoto, Y., 2017/10/01, In: Clinical and Experimental Nephrology. 21, 5, p. 884-888 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
1 被引用数 (Scopus) -
2016
Population pharmacokinetics of mizoribine in pediatric patients with kidney disease
Kaneda, H., Shimizu, M., Ohta, K., Ushijima, K., Gotoh, Y., Satomura, K., Nagai, T., Fujieda, M., Morooka, M., Yamada, T., Yamada, M., Wada, N., Takaai, M., Hashimoto, Y. & Uemura, O., 2016/10/01, In: Clinical and Experimental Nephrology. 20, 5, p. 757-763 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
2 被引用数 (Scopus) -
Presence of an H+/Quinidine Antiport System in Madin–Darby Canine Kidney Cells
Fukao, M., Kondo, E., Nishino, H., Hattori, R., Horie, A. & Hashimoto, Y., 2016/12/01, In: European Journal of Drug Metabolism and Pharmacokinetics. 41, 6, p. 819-824 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
3 被引用数 (Scopus) -
2014
Effect of chronic hypoxic hypoxia on oxidation and glucuronidation of carvedilol in rats
Yamaura, S., Fukao, M., Ishida, K., Taguchi, M. & Hashimoto, Y., 2014/03, In: European Journal of Drug Metabolism and Pharmacokinetics. 39, 1, p. 53-59 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
1 被引用数 (Scopus) -
Membrane transport mechanisms of choline in human intestinal epithelial LS180 cells
Horie, A., Ishida, K., Watanabe, Y., Shibata, K. & Hashimoto, Y., 2014/12, In: Biopharmaceutics and Drug Disposition. 35, 9, p. 532-542 11 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
14 被引用数 (Scopus) -
Pharmacokinetic variability of flecainide in younger Japanese patients and mechanisms for renal excretion and intestinal absorption
Horie, A., Ishida, K., Shibata, K., Taguchi, M., Ozawa, A., Hirono, K., Ichida, F. & Hashimoto, Y., 2014/04, In: Biopharmaceutics and Drug Disposition. 35, 3, p. 145-153 9 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
11 被引用数 (Scopus) -
Variability of bioavailability and intestinal absorption mechanisms of metoprolol
Fukao, M., Ishida, K., Horie, A., Taguchi, M., Nozawa, T., Inoue, H. & Hashimoto, Y., 2014, In: Drug Metabolism and Pharmacokinetics. 29, 2, p. 162-167 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
4 被引用数 (Scopus) -
2013
Effect of salt intake on bioavailability of mizoribine in healthy Japanese males
Ishida, K., Fukao, M., Watanabe, H., Taguchi, M., Miyawaki, T., Matsukura, H., Uemura, O., Zhang, Z., Unadkat, J. D. & Hashimoto, Y., 2013, In: Drug Metabolism and Pharmacokinetics. 28, 1, p. 75-80 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
7 被引用数 (Scopus) -
Variability of bioavailability and intestinal absorption characteristics of bisoprolol
Ishida, K., Horie, A., Nishimura, M., Taguchi, M., Fujii, N., Nozawa, T., Inoue, H. & Hashimoto, Y., 2013, In: Drug Metabolism and Pharmacokinetics. 28, 6, p. 491-496 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
5 被引用数 (Scopus) -
2012
Population pharmacokinetics of mizoribine in pediatric recipients of renal transplantation
Ishida, K., Motoyama, O., Shishido, S., Tsuzuki, K. & Hashimoto, Y., 2012/10, In: Clinical and Experimental Nephrology. 16, 5, p. 799-804 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
6 被引用数 (Scopus) -
2011
Evaluation of limited sampling designs to estimate maximal concentration and area under the curve of mizoribine in pediatric patients with renal disease
Ishida, K., Kaneda, H., Uemura, O., Ushijima, K., Ohta, K., Goto, Y., Satomura, K., Shimizu, M., Fujieda, M., Morooka, M., Yamada, T., Yamada, M., Wada, N., Takaai, M. & Hashimoto, Y., 2011, In: Drug Metabolism and Pharmacokinetics. 26, 1, p. 71-78 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
6 被引用数 (Scopus) -
Mechanisms for membrane transport of metformin in human intestinal epithelial Caco-2 cells
Horie, A., Sakata, J., Nishimura, M., Ishida, K., Taguchi, M. & Hashimoto, Y., 2011/07, In: Biopharmaceutics and Drug Disposition. 32, 5, p. 253-260 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
20 被引用数 (Scopus) -
Pharmacokinetics of bosentan in routinely treated Japanese pediatric patients with pulmonary arterial hypertension
Taguchi, M., Ichida, F., Hirono, K., Miyawaki, T., Yoshimura, N., Nakamura, T., Akita, C., Nakayama, T., Saji, T., Kato, Y., Horiuchi, I. & Hashimoto, Y., 2011, In: Drug Metabolism and Pharmacokinetics. 26, 3, p. 280-287 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
29 被引用数 (Scopus) -
Population pharmacokinetics of mizoribine in adult recipients of renal transplantation
Ishida, K., Okamoto, M., Ishibashi, M. & Hashimoto, Y., 2011/12, In: Clinical and Experimental Nephrology. 15, 6, p. 900-906 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
10 被引用数 (Scopus) -
2010
Effects of probenecid on the pharmacokinetics of mizoribine and co-administration of the two drugs in patients with nephrotic syndrome
Utsunomiya, Y., Hara, Y., Ito, H., Okonogi, H., Miyazaki, Y., Hashimoto, Y. & Hosoya, T., 2010/11, In: International Journal of Clinical Pharmacology and Therapeutics. 48, 11, p. 751-755 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
5 被引用数 (Scopus) -
Inhibitory and stimulative effects of amiodarone on metabolism of carvedilol in human liver microsomes
Horiuchi, I., Kato, Y., Nakamura, A., Ishida, K., Taguchi, M. & Hashimoto, Y., 2010/04/10, In: Biological and Pharmaceutical Bulletin. 33, 4, p. 717-720 4 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access4 被引用数 (Scopus) -
Membrane transport mechanisms of quinidine and procainamide in renal LLC-PK1 and intestinal LS180 cells
Masago, M., Takaai, M., Sakata, J., Horie, A., Ito, T., Ishida, K., Taguchi, M. & Hashimoto, Y., 2010, In: Biological and Pharmaceutical Bulletin. 33, 8, p. 1407-1412 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access16 被引用数 (Scopus) -
2009
A simulation study to evaluate limited sampling strategies to estimate area under the curve of drug concentration versus time following repetitive oral dosing: Limited sampling model versus naive trapezoidal method
Kayano, Y., Horiuchi, I., Mori, Y. I., Ishida, K., Saito, T., Taguchi, M. & Hashimoto, Y., 2009/08, In: Biological and Pharmaceutical Bulletin. 32, 8, p. 1486-1490 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access4 被引用数 (Scopus) -
Involvement of the CYP1A subfamily in stereoselective metabolism of carvedilol in β-naphthoflavone-treated Caco-2 cells
Ishida, K., Taguchi, M., Akao, T. & Hashimoto, Y., 2009/03, In: Biological and Pharmaceutical Bulletin. 32, 3, p. 513-516 4 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access12 被引用数 (Scopus) -
Mechanisms responsible for the altered pharmacokinetics of bosentan: Analysis utilizing rats with bile duct ligation-induced liver dysfunction
Horiuchi, I., Mori, Y. I., Taguchi, M., Ichida, F., Miyawaki, T. & Hashimoto, Y., 2009, In: Biopharmaceutics and Drug Disposition. 30, 6, p. 326-333 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
7 被引用数 (Scopus) -
Membrane transport mechanisms of mizoribine in the rat intestine and human epithelial LS180 cells
Ishida, K., Takaai, M., Yotsutani, A., Taguchi, M. & Hashimoto, Y., 2009/04, In: Biological and Pharmaceutical Bulletin. 32, 4, p. 741-745 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access13 被引用数 (Scopus) -
Temperature-dependent specific transport of levofloxacin in human intestinal epithelial LS180 cells
Fukumori, S., Masago, M., Ishida, K., Kayano, Y., Taguchi, M. & Hashimoto, Y., 2009, In: Biopharmaceutics and Drug Disposition. 30, 8, p. 448-456 9 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access6 被引用数 (Scopus) -
2008
Additional notes on clinical repeated-dose pharmacokinetic trials applying a peak-and-trough sampling design to estimate oral clearance
Takaai, M., Kayano, Y., Shimizu, T., Taguchi, M. & Hashimoto, Y., 2008, In: Drug Metabolism and Pharmacokinetics. 23, 2, p. 128-133 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
4 被引用数 (Scopus) -
Contribution of Na+-independent nucleoside transport to ribavirin uptake in the rat intestine and human epithelial LS180 cells
Takaai, M., Morishita, H., Ishida, K., Taguchi, M. & Hashimoto, Y., 2008/12/28, In: European Journal of Pharmacology. 601, 1-3, p. 61-65 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
11 被引用数 (Scopus) -
Directional transcellular transport of bisoprolol in P-glycoprotein-expressed LLC-GA5-COL150 cells, but not in renal epithelial LLC-PK1 cells
Tahara, K., Kagawa, Y., Takaai, M., Taguchi, M. & Hashimoto, Y., 2008, In: Drug Metabolism and Pharmacokinetics. 23, 5, p. 340-346 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
16 被引用数 (Scopus) -
Pharmacokinetics of R- and S-carvedilol in routinely treated Japanese patients with heart failure
Horiuchi, I., Nozawa, T., Fujii, N., Inoue, H., Honda, M., Shimizu, T., Taguchi, M. & Hashimoto, Y., 2008/05, In: Biological and Pharmaceutical Bulletin. 31, 5, p. 976-980 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access21 被引用数 (Scopus) -
Population pharmacokinetics of teicoplanin in patients and simulation of trough concentrations after various initial loading doses
Nakamura, T., Igarashi, T., Yano, R., Tsukamoto, H., Hashimoto, Y. & Masada, M., 2008, In: Journal of Applied Therapeutic Research. 6, 4, p. 32-40 9 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
4 被引用数 (Scopus) -
Stereoselective oxidation and glucuronidation of carvedilol in human liver and intestinal microsomes
Ishida, K., Taira, S., Morishita, H., Kayano, Y., Taguchi, M. & Hashimoto, Y., 2008/06, In: Biological and Pharmaceutical Bulletin. 31, 6, p. 1297-1300 4 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access29 被引用数 (Scopus) -
The apical uptake transporter of levofloxacin is distinct from the peptide transporter in human intestinal epithelial Caco-2 cells
Fukumori, S., Murata, T., Takaai, M., Tahara, K., Taguchi, M. & Hashimoto, Y., 2008, In: Drug Metabolism and Pharmacokinetics. 23, 5, p. 373-378 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
7 被引用数 (Scopus) -
2007
Nonlinear mixed effects model analysis of the pharmacokinetics of aripiprazole in healthy Japanese males
Koue, T., Kubo, M., Funaki, T., Fukuda, T., Azuma, J., Takaai, M., Kayano, Y. & Hashimoto, Y., 2007/11, In: Biological and Pharmaceutical Bulletin. 30, 11, p. 2154-2158 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access15 被引用数 (Scopus) -
Pharmacokinetic analysis of transcellular transport of levofloxacin across LLC-PK1 and Caco-2 cell monolayers
Takaai, M., Suzuki, H., Ishida, K., Tahara, K. & Hashimoto, Y., 2007/11, In: Biological and Pharmaceutical Bulletin. 30, 11, p. 2167-2172 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access18 被引用数 (Scopus) -
Pharmacokinetics and hepatic extraction of metoprolol in rats with glycerol-induced acute renal failure
Tanabe, H., Taira, S., Taguchi, M. & Hashimoto, Y., 2007/03, In: Biological and Pharmaceutical Bulletin. 30, 3, p. 552-555 4 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access17 被引用数 (Scopus) -
Population pharmacokinetics and proton pump inhibitory effects of intravenous lansoprazole in healthy Japanese males
Sakurai, Y., Hirayama, M., Hashimoto, M., Tanaka, T., Hasegawa, S., Irie, S., Ashida, K., Kayano, Y., Taguchi, M. & Hashimoto, Y., 2007/12, In: Biological and Pharmaceutical Bulletin. 30, 12, p. 2238-2243 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access15 被引用数 (Scopus) -
Rapid and drastic induction of CYP3A4 mRNA expression via vitamin D receptor in human intestinal LS180 cells.
Fukumori, S., Murata, T., Taguchi, M. & Hashimoto, Y., 2007/10, In: Drug Metabolism and Pharmacokinetics. 22, 5, p. 377-381 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
26 被引用数 (Scopus) -
Simulation for clinical repeated-dose pharmacokinetic trials applying a peak-and-trough sampling design to estimate oral clearance
Ishida, K., Kayano, Y., Taguchi, M. & Hashimoto, Y., 2007/11, In: Biological and Pharmaceutical Bulletin. 30, 11, p. 2159-2162 4 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access4 被引用数 (Scopus) -
Stereoselective metabolism of carvedilol by the β-naphthoflavone- inducible enzyme in human intestinal epithelial Caco-2 cells
Ishida, K., Honda, M., Shimizu, T., Taguchi, M. & Hashimoto, Y., 2007/10, In: Biological and Pharmaceutical Bulletin. 30, 10, p. 1930-1933 4 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access6 被引用数 (Scopus) -
UGT2B7*3 did not affect the pharmacokinetics of R- and S-carvedilol in healthy Japanese.
Honda, M., Toyoda, W., Shimizu, T., Horiuchi, I., Kayano, Y., Taguchi, M., Nozawa, T., Inoue, H. & Hashimoto, Y., 2007/10, In: Drug Metabolism and Pharmacokinetics. 22, 5, p. 382-386 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
7 被引用数 (Scopus) -
2006
Endogenous uremic substances are not involved in the reduced hepatic extraction of metoprolol in bilateral ureter-ligated rats.
Taguchi, M., Urai, M., Taira, S., Tanabe, H. & Hashimoto, Y., 2006/04, In: Drug Metabolism and Pharmacokinetics. 21, 2, p. 156-164 9 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
2 被引用数 (Scopus) -
Multiple regression analysis of pharmacogenetic variability of carvedilol disposition in 54 healthy Japanese volunteers
Honda, M., Ogura, Y., Toyoda, W., Taguchi, M., Nozawa, T., Inoue, H. & Hashimoto, Y., 2006/04, In: Biological and Pharmaceutical Bulletin. 29, 4, p. 772-778 7 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access40 被引用数 (Scopus) -
Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias
Taguchi, M., Fujiki, A., Iwamoto, J., Inoue, H., Tahara, K., Saigusa, K., Horiuchi, I., Oshima, Y. & Hashimoto, Y., 2006/03, In: Biological and Pharmaceutical Bulletin. 29, 3, p. 517-521 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access10 被引用数 (Scopus) -
Pharmacokinetic analysis of transcellular transport of quinidine across monolayers of human intestinal epithelial Caco-2 cells
Ishida, K., Takaai, M. & Hashimoto, Y., 2006/03, In: Biological and Pharmaceutical Bulletin. 29, 3, p. 522-526 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access19 被引用数 (Scopus) -
Pharmacokinetics and pharmacodynamics of bisoprolol in rats with bilateral ureter ligation-induced renal failure.
Tahara, K., Saigusa, K., Kagawa, Y., Taguchi, M. & Hashimoto, Y., 2006/10, In: Drug Metabolism and Pharmacokinetics. 21, 5, p. 389-394 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
4 被引用数 (Scopus) -
Population pharmacokinetics of higher-dose mizoribine in healthy male volunteers
Honda, M., Itoh, H., Suzuki, T. & Hashimoto, Y., 2006/12, In: Biological and Pharmaceutical Bulletin. 29, 12, p. 2460-2464 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access25 被引用数 (Scopus) -
2005
Effect of CYP2D6*10 on the pharmacokinetics of R- and S-carvedilol in healthy Japanese volunteers
Honda, M., Nozawa, T., Igarashi, N., Inoue, H., Arakawa, R., Ogura, Y., Okabe, H., Taguchi, M. & Hashimoto, Y., 2005/08, In: Biological and Pharmaceutical Bulletin. 28, 8, p. 1476-1479 4 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access45 被引用数 (Scopus) -
Evaluation of phenytoin dosage regimens based on genotyping of CYP2C subfamily in routinely treated Japanese patients.
Taguchi, M., Hongou, K., Yagi, S., Miyawaki, T., Takizawa, M., Aiba, T. & Hashimoto, Y., 2005/04, In: Drug Metabolism and Pharmacokinetics. 20, 2, p. 107-112 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
26 被引用数 (Scopus) -
Influence of CYP2D6 genotype on metoprolol plasma concentration and β-adrenergic inhibition during long-term treatment: A comparison with bisoprolol
Nozawa, T., Taguchi, M., Tahara, K., Hashimoto, Y., Igarashi, N., Nonomura, M., Kato, B. I., Igawa, A. & Inoue, H., 2005/11, In: Journal of Cardiovascular Pharmacology. 46, 5, p. 713-720 8 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access61 被引用数 (Scopus) -
Intestinal expression and metabolic activity of the CYP3A subfamily in female rats
Aiba, T., Yoshinaga, M., Ishida, K., Takehara, Y. & Hashimoto, Y., 2005/02, In: Biological and Pharmaceutical Bulletin. 28, 2, p. 311-315 5 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access34 被引用数 (Scopus) -
Mechanism responsible for the decreased hepatic NADPH generation rate in rats with bilateral ureter ligation-induced renal failure
Higashi, T., Urai, M., Taguchi, M. & Hashimoto, Y., 2005/09, In: Biological and Pharmaceutical Bulletin. 28, 9, p. 1809-1812 4 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access3 被引用数 (Scopus) -
Pharmacokinetic characterization of transcellular transport and drug interaction of digoxin in Caco-2 cell monolayers
Aiba, T., Ishida, K., Yoshinaga, M., Okuno, M. & Hashimoto, Y., 2005/01, In: Biological and Pharmaceutical Bulletin. 28, 1, p. 114-119 6 p.研究成果: ジャーナルへの寄稿 › 学術論文 › 査読
Open Access23 被引用数 (Scopus)