Toll-like receptor signaling in uterine natural killer cells-role in embryonic loss

Yi Lin; Akitoshi Nakashima; Tomoko Shima; Xing Zhou; Shigeru Saito

doi:10.1016/j.jri.2009.09.004

Toll-like receptor signaling in uterine natural killer cells-role in embryonic loss

Yi Lin^*, Akitoshi Nakashima, Tomoko Shima, Xing Zhou, Shigeru Saito

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Embryonic development is a complex process that is regulated by many cell types and signaling pathways. This review focuses on the role of NK cells and regulatory T-cells (Treg cells) in embryonic loss. Approximately 70% of uterine leukocytes until the time of mid-gestation are found to be CD16^-CD56^bright NK cells. This subset of NK cells, along with Treg cells, has been shown to regulate fetal development. We recently found a population of NK cells in the pregnant mouse uterus with a unique CD3^-CD49b⁺CD25⁺Foxp3⁺ phenotype. This review summarizes the studies indicating critical roles for expression of IL-10 by CD3^-CD49b⁺CD25⁺Foxp3⁺ cells and CXCR4 expression on CD16^-CD56^bright NK cells in preventing embryonic loss. In addition, the roles of toll-like receptors (TLRs) and CXCR4 in NK cell migration and functional modulation are discussed.

Original language	English
Pages (from-to)	95-100
Number of pages	6
Journal	Journal of Reproductive Immunology
Volume	83
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jri.2009.09.004
State	Published - 2009/01

Keywords

Immune modulation
Immune tolerance
Pregnancy
Toll-like receptor
uNK cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Reproductive Medicine
Obstetrics and Gynecology

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10.1016/j.jri.2009.09.004

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title = "Toll-like receptor signaling in uterine natural killer cells-role in embryonic loss",

abstract = "Embryonic development is a complex process that is regulated by many cell types and signaling pathways. This review focuses on the role of NK cells and regulatory T-cells (Treg cells) in embryonic loss. Approximately 70% of uterine leukocytes until the time of mid-gestation are found to be CD16-CD56bright NK cells. This subset of NK cells, along with Treg cells, has been shown to regulate fetal development. We recently found a population of NK cells in the pregnant mouse uterus with a unique CD3-CD49b+CD25+Foxp3+ phenotype. This review summarizes the studies indicating critical roles for expression of IL-10 by CD3-CD49b+CD25+Foxp3+ cells and CXCR4 expression on CD16-CD56bright NK cells in preventing embryonic loss. In addition, the roles of toll-like receptors (TLRs) and CXCR4 in NK cell migration and functional modulation are discussed.",

keywords = "Immune modulation, Immune tolerance, Pregnancy, Toll-like receptor, uNK cells",

author = "Yi Lin and Akitoshi Nakashima and Tomoko Shima and Xing Zhou and Shigeru Saito",

note = "Funding Information: Work in the authors{\textquoteright} laboratories was funded by the National Natural Science Foundation of China ( 30672231 , 30730087 and 30872761 ); the National Basic Research Program of China ( 2006CB944007 ); and Grants from the Ministry of Education, Culture, Sports, Science and Technology, Japan [Grant-in Aid for Scientific Research (B)- 20390431 and Grant-in-Aid for Exploratory Research 18659482 ] and [Grant-in-Aid H20-kodomo-ippan-002 from the Ministry of Health, Labor and Welfare].",

year = "2009",

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doi = "10.1016/j.jri.2009.09.004",

language = "英語",

volume = "83",

pages = "95--100",

journal = "Journal of Reproductive Immunology",

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AU - Lin, Yi

AU - Nakashima, Akitoshi

AU - Shima, Tomoko

AU - Zhou, Xing

AU - Saito, Shigeru

N1 - Funding Information: Work in the authors’ laboratories was funded by the National Natural Science Foundation of China ( 30672231 , 30730087 and 30872761 ); the National Basic Research Program of China ( 2006CB944007 ); and Grants from the Ministry of Education, Culture, Sports, Science and Technology, Japan [Grant-in Aid for Scientific Research (B)- 20390431 and Grant-in-Aid for Exploratory Research 18659482 ] and [Grant-in-Aid H20-kodomo-ippan-002 from the Ministry of Health, Labor and Welfare].

PY - 2009/1

Y1 - 2009/1

N2 - Embryonic development is a complex process that is regulated by many cell types and signaling pathways. This review focuses on the role of NK cells and regulatory T-cells (Treg cells) in embryonic loss. Approximately 70% of uterine leukocytes until the time of mid-gestation are found to be CD16-CD56bright NK cells. This subset of NK cells, along with Treg cells, has been shown to regulate fetal development. We recently found a population of NK cells in the pregnant mouse uterus with a unique CD3-CD49b+CD25+Foxp3+ phenotype. This review summarizes the studies indicating critical roles for expression of IL-10 by CD3-CD49b+CD25+Foxp3+ cells and CXCR4 expression on CD16-CD56bright NK cells in preventing embryonic loss. In addition, the roles of toll-like receptors (TLRs) and CXCR4 in NK cell migration and functional modulation are discussed.

AB - Embryonic development is a complex process that is regulated by many cell types and signaling pathways. This review focuses on the role of NK cells and regulatory T-cells (Treg cells) in embryonic loss. Approximately 70% of uterine leukocytes until the time of mid-gestation are found to be CD16-CD56bright NK cells. This subset of NK cells, along with Treg cells, has been shown to regulate fetal development. We recently found a population of NK cells in the pregnant mouse uterus with a unique CD3-CD49b+CD25+Foxp3+ phenotype. This review summarizes the studies indicating critical roles for expression of IL-10 by CD3-CD49b+CD25+Foxp3+ cells and CXCR4 expression on CD16-CD56bright NK cells in preventing embryonic loss. In addition, the roles of toll-like receptors (TLRs) and CXCR4 in NK cell migration and functional modulation are discussed.

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KW - Immune tolerance

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Toll-like receptor signaling in uterine natural killer cells-role in embryonic loss

Abstract

Keywords

ASJC Scopus subject areas

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