Three new inositol derivatives from Chisocheton paniculatus

Hoai Thi Nguyen; Linh Thuy Thi Tran; Duc Viet Ho; Kiem Van Phan; Ain Raal; Hiroyuki Morita

doi:10.1016/j.tetlet.2019.06.015

Three new inositol derivatives from Chisocheton paniculatus

Hoai Thi Nguyen, Linh Thuy Thi Tran, Duc Viet Ho, Kiem Van Phan, Ain Raal, Hiroyuki Morita^*

^*Corresponding author for this work

Section of Natural Products & Drug Discovery, Division of Medicinal Resources, Institute of Natural Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Three new inositol derivatives (1–3) were isolated from the leaves of Chisocheton paniculatus collected in Vietnam, along with four known compounds, including a limonoid (4), two triterpenoids (5–6), and a tocopherol (7). The structures of the new compounds were elucidated by 1D- and 2D-NMR and HRESIMS analyses. Compound 4 showed the highest cytotoxicities against the human lung cancer A549 and cervical cancer HeLa cell lines, with IC₅₀ values of 7.3 and 8.8 µM, respectively, among the isolated compounds. Compounds 5 and 7 displayed moderate to weak cytotoxicities against the A549, HeLa, and human stomach cancer GSU cell lines, with IC₅₀ values ranging from 17.7 to 68.0 µM.

Original language	English
Pages (from-to)	1841-1844
Number of pages	4
Journal	Tetrahedron Letters
Volume	60
Issue number	28
DOIs	https://doi.org/10.1016/j.tetlet.2019.06.015
State	Published - 2019/07/11

Keywords

Chisocheton paniculatus
Cytotoxic activity
Inositol derivatives
Meliaceae

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2019.06.015

Cite this

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title = "Three new inositol derivatives from Chisocheton paniculatus",

abstract = "Three new inositol derivatives (1–3) were isolated from the leaves of Chisocheton paniculatus collected in Vietnam, along with four known compounds, including a limonoid (4), two triterpenoids (5–6), and a tocopherol (7). The structures of the new compounds were elucidated by 1D- and 2D-NMR and HRESIMS analyses. Compound 4 showed the highest cytotoxicities against the human lung cancer A549 and cervical cancer HeLa cell lines, with IC50 values of 7.3 and 8.8 µM, respectively, among the isolated compounds. Compounds 5 and 7 displayed moderate to weak cytotoxicities against the A549, HeLa, and human stomach cancer GSU cell lines, with IC50 values ranging from 17.7 to 68.0 µM.",

keywords = "Chisocheton paniculatus, Cytotoxic activity, Inositol derivatives, Meliaceae",

author = "Nguyen, {Hoai Thi} and Tran, {Linh Thuy Thi} and Ho, {Duc Viet} and Phan, {Kiem Van} and Ain Raal and Hiroyuki Morita",

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doi = "10.1016/j.tetlet.2019.06.015",

language = "英語",

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journal = "Tetrahedron Letters",

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T1 - Three new inositol derivatives from Chisocheton paniculatus

AU - Nguyen, Hoai Thi

AU - Tran, Linh Thuy Thi

AU - Ho, Duc Viet

AU - Phan, Kiem Van

AU - Raal, Ain

AU - Morita, Hiroyuki

PY - 2019/7/11

Y1 - 2019/7/11

N2 - Three new inositol derivatives (1–3) were isolated from the leaves of Chisocheton paniculatus collected in Vietnam, along with four known compounds, including a limonoid (4), two triterpenoids (5–6), and a tocopherol (7). The structures of the new compounds were elucidated by 1D- and 2D-NMR and HRESIMS analyses. Compound 4 showed the highest cytotoxicities against the human lung cancer A549 and cervical cancer HeLa cell lines, with IC50 values of 7.3 and 8.8 µM, respectively, among the isolated compounds. Compounds 5 and 7 displayed moderate to weak cytotoxicities against the A549, HeLa, and human stomach cancer GSU cell lines, with IC50 values ranging from 17.7 to 68.0 µM.

AB - Three new inositol derivatives (1–3) were isolated from the leaves of Chisocheton paniculatus collected in Vietnam, along with four known compounds, including a limonoid (4), two triterpenoids (5–6), and a tocopherol (7). The structures of the new compounds were elucidated by 1D- and 2D-NMR and HRESIMS analyses. Compound 4 showed the highest cytotoxicities against the human lung cancer A549 and cervical cancer HeLa cell lines, with IC50 values of 7.3 and 8.8 µM, respectively, among the isolated compounds. Compounds 5 and 7 displayed moderate to weak cytotoxicities against the A549, HeLa, and human stomach cancer GSU cell lines, with IC50 values ranging from 17.7 to 68.0 µM.

KW - Chisocheton paniculatus

KW - Cytotoxic activity

KW - Inositol derivatives

KW - Meliaceae

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DO - 10.1016/j.tetlet.2019.06.015

M3 - 学術論文

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SN - 0040-4039

VL - 60

SP - 1841

EP - 1844

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 28

ER -

Three new inositol derivatives from Chisocheton paniculatus

Abstract

Keywords

ASJC Scopus subject areas

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