The Pro12Ala polymorphism in PPAR γ2 may confer resistance to type 2 diabetes

Kazuo Hara; Terumasa Okada; Kazuyuki Tobe; Kazuki Yasuda; Yasumichi Mori; Hiroko Kadowaki; Ryoko Hagura; Yasuo Akanuma; Satoshi Kimura; Chikako Ito; Takashi Kadowaki

doi:10.1006/bbrc.2000.2605

The Pro12Ala polymorphism in PPAR γ2 may confer resistance to type 2 diabetes

Kazuo Hara, Terumasa Okada, Kazuyuki Tobe, Kazuki Yasuda, Yasumichi Mori, Hiroko Kadowaki, Ryoko Hagura, Yasuo Akanuma, Satoshi Kimura, Chikako Ito, Takashi Kadowaki^*

^*Corresponding author for this work

Internal Medicine （1）

Research output: Contribution to journal › Article › peer-review

281 Scopus citations

Abstract

Peroxisome proliferator-activated receptor γ (PPARγ) has been implicated in adipocyte differentiation. Recently it was reported that heterozygous deficiency of PPARγ led to the protection from high-fat diet-induced insulin resistance in an animal model. A Pro12Ala polymorphism has been detected in the human PPARγ2 gene. Since this amino acid substitution may cause a reduction in the transcriptional activity of PPARγ, this polymorphism may be associated with decreased insulin resistance and decreased risk of type 2 diabetes. To investigate this hypothesis, we performed a case-control study of the Pro12Ala PPARγ2 polymorphism in Japanese diabetic and non-diabetic subjects. The frequency of Ala12 was significantly lower in the diabetic group. In an overweight or obese group, subjects with Ala12 were more insulin sensitive than those without. These results suggest that the PPARγ is a thrifty gene and that the Pro12Ala PPARγ2 polymorphism protects against type 2 diabetes in the Japanese. (C) 2000 Academic Press.

Original language	English
Pages (from-to)	212-216
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	271
Issue number	1
DOIs	https://doi.org/10.1006/bbrc.2000.2605
State	Published - 2000/04/29

Keywords

Insulin resistance
Peroxisome proliferator-activated receptor γ
Pro12Ala polymorphism
Thrifty gene
Type 2 diabetes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1006/bbrc.2000.2605

Cite this

@article{0a483eedb47c4e89bf870e837b7b2c28,

title = "The Pro12Ala polymorphism in PPAR γ2 may confer resistance to type 2 diabetes",

abstract = "Peroxisome proliferator-activated receptor γ (PPARγ) has been implicated in adipocyte differentiation. Recently it was reported that heterozygous deficiency of PPARγ led to the protection from high-fat diet-induced insulin resistance in an animal model. A Pro12Ala polymorphism has been detected in the human PPARγ2 gene. Since this amino acid substitution may cause a reduction in the transcriptional activity of PPARγ, this polymorphism may be associated with decreased insulin resistance and decreased risk of type 2 diabetes. To investigate this hypothesis, we performed a case-control study of the Pro12Ala PPARγ2 polymorphism in Japanese diabetic and non-diabetic subjects. The frequency of Ala12 was significantly lower in the diabetic group. In an overweight or obese group, subjects with Ala12 were more insulin sensitive than those without. These results suggest that the PPARγ is a thrifty gene and that the Pro12Ala PPARγ2 polymorphism protects against type 2 diabetes in the Japanese. (C) 2000 Academic Press.",

keywords = "Insulin resistance, Peroxisome proliferator-activated receptor γ, Pro12Ala polymorphism, Thrifty gene, Type 2 diabetes",

author = "Kazuo Hara and Terumasa Okada and Kazuyuki Tobe and Kazuki Yasuda and Yasumichi Mori and Hiroko Kadowaki and Ryoko Hagura and Yasuo Akanuma and Satoshi Kimura and Chikako Ito and Takashi Kadowaki",

note = "Funding Information: This work was supported by Health Sciences Research Grants (Research on Human Genome and Gene Therapy) from the Ministry of Health and Welfare (to T. Kadowaki). We thank Yuko Okada for technical assistance. This work was also supported by grant-in-aid from Ministry of Education, Science, Sports and Culture (to T. Kadowaki).",

year = "2000",

month = apr,

day = "29",

doi = "10.1006/bbrc.2000.2605",

language = "英語",

volume = "271",

pages = "212--216",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - The Pro12Ala polymorphism in PPAR γ2 may confer resistance to type 2 diabetes

AU - Hara, Kazuo

AU - Okada, Terumasa

AU - Tobe, Kazuyuki

AU - Yasuda, Kazuki

AU - Mori, Yasumichi

AU - Kadowaki, Hiroko

AU - Hagura, Ryoko

AU - Akanuma, Yasuo

AU - Kimura, Satoshi

AU - Ito, Chikako

AU - Kadowaki, Takashi

N1 - Funding Information: This work was supported by Health Sciences Research Grants (Research on Human Genome and Gene Therapy) from the Ministry of Health and Welfare (to T. Kadowaki). We thank Yuko Okada for technical assistance. This work was also supported by grant-in-aid from Ministry of Education, Science, Sports and Culture (to T. Kadowaki).

PY - 2000/4/29

Y1 - 2000/4/29

N2 - Peroxisome proliferator-activated receptor γ (PPARγ) has been implicated in adipocyte differentiation. Recently it was reported that heterozygous deficiency of PPARγ led to the protection from high-fat diet-induced insulin resistance in an animal model. A Pro12Ala polymorphism has been detected in the human PPARγ2 gene. Since this amino acid substitution may cause a reduction in the transcriptional activity of PPARγ, this polymorphism may be associated with decreased insulin resistance and decreased risk of type 2 diabetes. To investigate this hypothesis, we performed a case-control study of the Pro12Ala PPARγ2 polymorphism in Japanese diabetic and non-diabetic subjects. The frequency of Ala12 was significantly lower in the diabetic group. In an overweight or obese group, subjects with Ala12 were more insulin sensitive than those without. These results suggest that the PPARγ is a thrifty gene and that the Pro12Ala PPARγ2 polymorphism protects against type 2 diabetes in the Japanese. (C) 2000 Academic Press.

AB - Peroxisome proliferator-activated receptor γ (PPARγ) has been implicated in adipocyte differentiation. Recently it was reported that heterozygous deficiency of PPARγ led to the protection from high-fat diet-induced insulin resistance in an animal model. A Pro12Ala polymorphism has been detected in the human PPARγ2 gene. Since this amino acid substitution may cause a reduction in the transcriptional activity of PPARγ, this polymorphism may be associated with decreased insulin resistance and decreased risk of type 2 diabetes. To investigate this hypothesis, we performed a case-control study of the Pro12Ala PPARγ2 polymorphism in Japanese diabetic and non-diabetic subjects. The frequency of Ala12 was significantly lower in the diabetic group. In an overweight or obese group, subjects with Ala12 were more insulin sensitive than those without. These results suggest that the PPARγ is a thrifty gene and that the Pro12Ala PPARγ2 polymorphism protects against type 2 diabetes in the Japanese. (C) 2000 Academic Press.

KW - Insulin resistance

KW - Peroxisome proliferator-activated receptor γ

KW - Pro12Ala polymorphism

KW - Thrifty gene

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=0034728762&partnerID=8YFLogxK

U2 - 10.1006/bbrc.2000.2605

DO - 10.1006/bbrc.2000.2605

M3 - 学術論文

C2 - 10777704

AN - SCOPUS:0034728762

SN - 0006-291X

VL - 271

SP - 212

EP - 216

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 1

ER -

The Pro12Ala polymorphism in PPAR γ2 may confer resistance to type 2 diabetes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this