The Pro12Ala polymorphism in PPAR γ2 may confer resistance to type 2 diabetes

Kazuo Hara, Terumasa Okada, Kazuyuki Tobe, Kazuki Yasuda, Yasumichi Mori, Hiroko Kadowaki, Ryoko Hagura, Yasuo Akanuma, Satoshi Kimura, Chikako Ito, Takashi Kadowaki*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

281 Scopus citations

Abstract

Peroxisome proliferator-activated receptor γ (PPARγ) has been implicated in adipocyte differentiation. Recently it was reported that heterozygous deficiency of PPARγ led to the protection from high-fat diet-induced insulin resistance in an animal model. A Pro12Ala polymorphism has been detected in the human PPARγ2 gene. Since this amino acid substitution may cause a reduction in the transcriptional activity of PPARγ, this polymorphism may be associated with decreased insulin resistance and decreased risk of type 2 diabetes. To investigate this hypothesis, we performed a case-control study of the Pro12Ala PPARγ2 polymorphism in Japanese diabetic and non-diabetic subjects. The frequency of Ala12 was significantly lower in the diabetic group. In an overweight or obese group, subjects with Ala12 were more insulin sensitive than those without. These results suggest that the PPARγ is a thrifty gene and that the Pro12Ala PPARγ2 polymorphism protects against type 2 diabetes in the Japanese. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)212-216
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume271
Issue number1
DOIs
StatePublished - 2000/04/29

Keywords

  • Insulin resistance
  • Peroxisome proliferator-activated receptor γ
  • Pro12Ala polymorphism
  • Thrifty gene
  • Type 2 diabetes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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