The enantioselective synthesis of poison-frog alkaloids (-)-203A, (-)-209B, (-)-231C, (-)-233D, and (-)-235B″

Naoki Toyooka*, Zhou Dejun, Hideo Nemoto, H. Martin Garraffo, Thomas F. Spande, John W. Daly

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The enantioselective synthesis of indolizidines (-)-203A, (-)-209B, (-)-231C, (-)-233D, and (-)-235B″ has been achieved and the absolute stereochemistry of both indolizidines 203A and 233D was established as 5S,8R,9S. The relative stereochemistry of natural 231C was established by the present asymmetric synthesis.

Original languageEnglish
Pages (from-to)577-580
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number4
DOIs
StatePublished - 2006/01/23

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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