Th1/Th2/Th17 and Regulatory T-Cell Paradigm in Pregnancy

Shigeru Saito; Akitoshi Nakashima; Tomoko Shima; Mika Ito

doi:10.1111/j.1600-0897.2010.00852.x

Th1/Th2/Th17 and Regulatory T-Cell Paradigm in Pregnancy

Shigeru Saito^*, Akitoshi Nakashima, Tomoko Shima, Mika Ito

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

1007 Scopus citations

Abstract

T-helper (Th) cells play a central role in modulating immune responses. The Th1/Th2 paradigm has now developed into the new Th1/Th2/Th17 paradigm. In addition to effector cells, Th cells are regulated by regulatory T (Treg) cells. Their capacity to produce cytokines is suppressed by immunoregulatory cytokines such as transforming growth factor (TGF)-β and interleukin (IL)-10 or by cell-to-cell interaction. Here, we will review the immunological environment in normal pregnancy and complicated pregnancy, such as implantation failure, abortion, preterm labor, and preeclampsia from the viewpoint of the new Th1/Th2/Th17 and Treg paradigms.

Original language	English
Pages (from-to)	601-610
Number of pages	10
Journal	American Journal of Reproductive Immunology
Volume	63
Issue number	6
DOIs	https://doi.org/10.1111/j.1600-0897.2010.00852.x
State	Published - 2010/06

Keywords

Abortion
Cytokine network
Implantation
Preterm labor
Reproduction

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Reproductive Medicine
Obstetrics and Gynecology

Access to Document

10.1111/j.1600-0897.2010.00852.x

Cite this

@article{687b472324414af79c054db0bcb45e07,

title = "Th1/Th2/Th17 and Regulatory T-Cell Paradigm in Pregnancy",

abstract = "T-helper (Th) cells play a central role in modulating immune responses. The Th1/Th2 paradigm has now developed into the new Th1/Th2/Th17 paradigm. In addition to effector cells, Th cells are regulated by regulatory T (Treg) cells. Their capacity to produce cytokines is suppressed by immunoregulatory cytokines such as transforming growth factor (TGF)-β and interleukin (IL)-10 or by cell-to-cell interaction. Here, we will review the immunological environment in normal pregnancy and complicated pregnancy, such as implantation failure, abortion, preterm labor, and preeclampsia from the viewpoint of the new Th1/Th2/Th17 and Treg paradigms.",

keywords = "Abortion, Cytokine network, Implantation, Preterm labor, Reproduction",

author = "Shigeru Saito and Akitoshi Nakashima and Tomoko Shima and Mika Ito",

year = "2010",

month = jun,

doi = "10.1111/j.1600-0897.2010.00852.x",

language = "英語",

volume = "63",

pages = "601--610",

journal = "American Journal of Reproductive Immunology",

issn = "1046-7408",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "6",

}

TY - JOUR

T1 - Th1/Th2/Th17 and Regulatory T-Cell Paradigm in Pregnancy

AU - Saito, Shigeru

AU - Nakashima, Akitoshi

AU - Shima, Tomoko

AU - Ito, Mika

PY - 2010/6

Y1 - 2010/6

N2 - T-helper (Th) cells play a central role in modulating immune responses. The Th1/Th2 paradigm has now developed into the new Th1/Th2/Th17 paradigm. In addition to effector cells, Th cells are regulated by regulatory T (Treg) cells. Their capacity to produce cytokines is suppressed by immunoregulatory cytokines such as transforming growth factor (TGF)-β and interleukin (IL)-10 or by cell-to-cell interaction. Here, we will review the immunological environment in normal pregnancy and complicated pregnancy, such as implantation failure, abortion, preterm labor, and preeclampsia from the viewpoint of the new Th1/Th2/Th17 and Treg paradigms.

AB - T-helper (Th) cells play a central role in modulating immune responses. The Th1/Th2 paradigm has now developed into the new Th1/Th2/Th17 paradigm. In addition to effector cells, Th cells are regulated by regulatory T (Treg) cells. Their capacity to produce cytokines is suppressed by immunoregulatory cytokines such as transforming growth factor (TGF)-β and interleukin (IL)-10 or by cell-to-cell interaction. Here, we will review the immunological environment in normal pregnancy and complicated pregnancy, such as implantation failure, abortion, preterm labor, and preeclampsia from the viewpoint of the new Th1/Th2/Th17 and Treg paradigms.

KW - Abortion

KW - Cytokine network

KW - Implantation

KW - Preterm labor

KW - Reproduction

UR - http://www.scopus.com/inward/record.url?scp=77953924059&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0897.2010.00852.x

DO - 10.1111/j.1600-0897.2010.00852.x

M3 - 総説

C2 - 20455873

AN - SCOPUS:77953924059

SN - 1046-7408

VL - 63

SP - 601

EP - 610

JO - American Journal of Reproductive Immunology

JF - American Journal of Reproductive Immunology

IS - 6

ER -

Th1/Th2/Th17 and Regulatory T-Cell Paradigm in Pregnancy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this