TAC-101 inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma

Soo Jin Lee; Yasukata Ohashi; Hiroaki Sakurai; Ikuo Saiki

doi:10.1016/S0304-3835(03)00306-9

TAC-101 inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma

Soo Jin Lee, Yasukata Ohashi, Hiroaki Sakurai, Ikuo Saiki^*

^*Corresponding author for this work

Cancer Cell Biology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The anti-metastatic effect of 4-[3,5-bis(trimethylsilyl)benzamido]benzoic acid (TAC-101) was investigated using our established intrahepatic metastasis model. Orthotopic implantation of a fragment of CBO140C12 hepatoma into the liver resulted in the formation of a solitary tumor nodule and its intrahepatic metastasis. Daily oral administration of TAC-101 at a dose of 8 mg/kg resulted in a significant inhibition of intrahepatic metastasis, but did not affect the growth of the tumor at the implanted site. The down-regulation of transcriptional anti-activator protein-1 (AP-1) activity by TAC-101 paralleled the inhibition of cell invasion and migration through the repression of expression of the mRNAs for urokinase-type plasminogen activator (u-PA) and its receptor (u-PAR). These findings suggest that TAC-101 may improve therapeutic efficacy for liver cancer patients to prevent intrahepatic metastasis.

Original language	English
Pages (from-to)	169-177
Number of pages	9
Journal	Cancer Letters
Volume	198
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(03)00306-9
State	Published - 2003/08

Keywords

AP-1
Hepatocellular carcinoma
Intrahepatic metastasis
TAC-101
u-PA

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(03)00306-9

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@article{177ca6c1ae9946ab9c79869dc5668392,

title = "TAC-101 inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma",

abstract = "The anti-metastatic effect of 4-[3,5-bis(trimethylsilyl)benzamido]benzoic acid (TAC-101) was investigated using our established intrahepatic metastasis model. Orthotopic implantation of a fragment of CBO140C12 hepatoma into the liver resulted in the formation of a solitary tumor nodule and its intrahepatic metastasis. Daily oral administration of TAC-101 at a dose of 8 mg/kg resulted in a significant inhibition of intrahepatic metastasis, but did not affect the growth of the tumor at the implanted site. The down-regulation of transcriptional anti-activator protein-1 (AP-1) activity by TAC-101 paralleled the inhibition of cell invasion and migration through the repression of expression of the mRNAs for urokinase-type plasminogen activator (u-PA) and its receptor (u-PAR). These findings suggest that TAC-101 may improve therapeutic efficacy for liver cancer patients to prevent intrahepatic metastasis.",

keywords = "AP-1, Hepatocellular carcinoma, Intrahepatic metastasis, TAC-101, u-PA",

author = "Lee, {Soo Jin} and Yasukata Ohashi and Hiroaki Sakurai and Ikuo Saiki",

note = "Funding Information: This study was supported in part by a Grant-in-Aid for Cancer Research (No. 14030028) from the Ministry of Education, culture, Sports, Science and Technology, Japan, and by a Grant-in Aid for Leading Regional Utilizing Potential of Regional Science and Technology from the Ministry of Education, Culture, Sports, Science and Technology, Japan.",

year = "2003",

month = aug,

doi = "10.1016/S0304-3835(03)00306-9",

language = "英語",

volume = "198",

pages = "169--177",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - TAC-101 inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma

AU - Lee, Soo Jin

AU - Ohashi, Yasukata

AU - Sakurai, Hiroaki

AU - Saiki, Ikuo

N1 - Funding Information: This study was supported in part by a Grant-in-Aid for Cancer Research (No. 14030028) from the Ministry of Education, culture, Sports, Science and Technology, Japan, and by a Grant-in Aid for Leading Regional Utilizing Potential of Regional Science and Technology from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

PY - 2003/8

Y1 - 2003/8

N2 - The anti-metastatic effect of 4-[3,5-bis(trimethylsilyl)benzamido]benzoic acid (TAC-101) was investigated using our established intrahepatic metastasis model. Orthotopic implantation of a fragment of CBO140C12 hepatoma into the liver resulted in the formation of a solitary tumor nodule and its intrahepatic metastasis. Daily oral administration of TAC-101 at a dose of 8 mg/kg resulted in a significant inhibition of intrahepatic metastasis, but did not affect the growth of the tumor at the implanted site. The down-regulation of transcriptional anti-activator protein-1 (AP-1) activity by TAC-101 paralleled the inhibition of cell invasion and migration through the repression of expression of the mRNAs for urokinase-type plasminogen activator (u-PA) and its receptor (u-PAR). These findings suggest that TAC-101 may improve therapeutic efficacy for liver cancer patients to prevent intrahepatic metastasis.

AB - The anti-metastatic effect of 4-[3,5-bis(trimethylsilyl)benzamido]benzoic acid (TAC-101) was investigated using our established intrahepatic metastasis model. Orthotopic implantation of a fragment of CBO140C12 hepatoma into the liver resulted in the formation of a solitary tumor nodule and its intrahepatic metastasis. Daily oral administration of TAC-101 at a dose of 8 mg/kg resulted in a significant inhibition of intrahepatic metastasis, but did not affect the growth of the tumor at the implanted site. The down-regulation of transcriptional anti-activator protein-1 (AP-1) activity by TAC-101 paralleled the inhibition of cell invasion and migration through the repression of expression of the mRNAs for urokinase-type plasminogen activator (u-PA) and its receptor (u-PAR). These findings suggest that TAC-101 may improve therapeutic efficacy for liver cancer patients to prevent intrahepatic metastasis.

KW - AP-1

KW - Hepatocellular carcinoma

KW - Intrahepatic metastasis

KW - TAC-101

KW - u-PA

UR - http://www.scopus.com/inward/record.url?scp=0142119397&partnerID=8YFLogxK

U2 - 10.1016/S0304-3835(03)00306-9

DO - 10.1016/S0304-3835(03)00306-9

M3 - 学術論文

C2 - 12957355

AN - SCOPUS:0142119397

SN - 0304-3835

VL - 198

SP - 169

EP - 177

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

TAC-101 inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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