Synthesis of macrosphelides containing a heterocyclic side chain as a novel apoptosis inducer

Yuji Matsuya; Ayana Hori; Tomomi Kawamura; Heba F. Emam; Kanwal Ahmed; Da Yong Yu; Takashi Kondo; Naoki Toyooka; Hideo Nemoto

doi:10.3987/COM-09-S(S)82

Synthesis of macrosphelides containing a heterocyclic side chain as a novel apoptosis inducer

Yuji Matsuya^*, Ayana Hori, Tomomi Kawamura, Heba F. Emam, Kanwal Ahmed, Da Yong Yu, Takashi Kondo, Naoki Toyooka, Hideo Nemoto

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Synthesis of macrosphelides containing a pyridyl or benzimidazolyl side chain is described. The synthesis was accomplished through sequential assembling of suitable chiral blocks and ring-closing metathesis (RCM) with a high efficiency. These novel derivatives were evaluated on the apoptosis-inducing activity against human lymphoma cells.

Original language	English
Pages (from-to)	579-591
Number of pages	13
Journal	Heterocycles
Volume	80
Issue number	1
DOIs	https://doi.org/10.3987/COM-09-S(S)82
State	Published - 2010/01/01

Keywords

Apoptosis
Macrolide
Macrosphelide
Pyridyl Side-Chain
Ring-Closing Metathesis

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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10.3987/COM-09-S(S)82

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title = "Synthesis of macrosphelides containing a heterocyclic side chain as a novel apoptosis inducer",

abstract = "Synthesis of macrosphelides containing a pyridyl or benzimidazolyl side chain is described. The synthesis was accomplished through sequential assembling of suitable chiral blocks and ring-closing metathesis (RCM) with a high efficiency. These novel derivatives were evaluated on the apoptosis-inducing activity against human lymphoma cells.",

keywords = "Apoptosis, Macrolide, Macrosphelide, Pyridyl Side-Chain, Ring-Closing Metathesis",

author = "Yuji Matsuya and Ayana Hori and Tomomi Kawamura and Emam, {Heba F.} and Kanwal Ahmed and Yu, {Da Yong} and Takashi Kondo and Naoki Toyooka and Hideo Nemoto",

year = "2010",

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doi = "10.3987/COM-09-S(S)82",

language = "英語",

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T1 - Synthesis of macrosphelides containing a heterocyclic side chain as a novel apoptosis inducer

AU - Matsuya, Yuji

AU - Hori, Ayana

AU - Kawamura, Tomomi

AU - Emam, Heba F.

AU - Ahmed, Kanwal

AU - Yu, Da Yong

AU - Kondo, Takashi

AU - Toyooka, Naoki

AU - Nemoto, Hideo

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Synthesis of macrosphelides containing a pyridyl or benzimidazolyl side chain is described. The synthesis was accomplished through sequential assembling of suitable chiral blocks and ring-closing metathesis (RCM) with a high efficiency. These novel derivatives were evaluated on the apoptosis-inducing activity against human lymphoma cells.

AB - Synthesis of macrosphelides containing a pyridyl or benzimidazolyl side chain is described. The synthesis was accomplished through sequential assembling of suitable chiral blocks and ring-closing metathesis (RCM) with a high efficiency. These novel derivatives were evaluated on the apoptosis-inducing activity against human lymphoma cells.

KW - Apoptosis

KW - Macrolide

KW - Macrosphelide

KW - Pyridyl Side-Chain

KW - Ring-Closing Metathesis

UR - http://www.scopus.com/inward/record.url?scp=76949106958&partnerID=8YFLogxK

U2 - 10.3987/COM-09-S(S)82

DO - 10.3987/COM-09-S(S)82

M3 - 学術論文

AN - SCOPUS:76949106958

SN - 0385-5414

VL - 80

SP - 579

EP - 591

JO - Heterocycles

JF - Heterocycles

IS - 1

ER -

Synthesis of macrosphelides containing a heterocyclic side chain as a novel apoptosis inducer

Abstract

Keywords

ASJC Scopus subject areas

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