TY - JOUR
T1 - Synthesis of large macrocyclic tetraaza compounds with a methylene backbone
T2 - Cyclo[‐NH‐ (CH2)n‐]4, (n = 6, 7, 8, 9 and 10). The formation of 28‐, 32‐, 36‐, 40‐ and 44‐membered rings
AU - Tomohiro, Takenori
AU - Uoto, Kouichi
AU - Okuno, Hiroaki (Yohmei)
PY - 1990
Y1 - 1990
N2 - A series of macrocyclic tetraamines with 28‐, 32‐, 36‐, 40‐ and 44‐membered rings have been efficiently prepared from the corresponding ditosylamide and monobromoalcohol derivatives in 6 steps via a double condensation reaction. Overall yields were: 41, 41, 46, 29, and 33%, respectively, for 1,8,15,22‐tetraazacyclooctacontane (11a), 1,9,17,25‐tetraazacyclodotriacontane (11b), 1,10,19,28‐tetraazacyclohexatriacontane (11c), 1,11,21,31‐tetraazacyclotetracontane (11d) and 1,12,23,34‐tetraazacyclotetratetracontane (11e).
AB - A series of macrocyclic tetraamines with 28‐, 32‐, 36‐, 40‐ and 44‐membered rings have been efficiently prepared from the corresponding ditosylamide and monobromoalcohol derivatives in 6 steps via a double condensation reaction. Overall yields were: 41, 41, 46, 29, and 33%, respectively, for 1,8,15,22‐tetraazacyclooctacontane (11a), 1,9,17,25‐tetraazacyclodotriacontane (11b), 1,10,19,28‐tetraazacyclohexatriacontane (11c), 1,11,21,31‐tetraazacyclotetracontane (11d) and 1,12,23,34‐tetraazacyclotetratetracontane (11e).
UR - http://www.scopus.com/inward/record.url?scp=7744239965&partnerID=8YFLogxK
U2 - 10.1002/jhet.5570270513
DO - 10.1002/jhet.5570270513
M3 - 学術論文
AN - SCOPUS:7744239965
SN - 0022-152X
VL - 27
SP - 1233
EP - 1239
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
IS - 5
ER -