Synthesis and glycosidase inhibition of C-7 modified casuarine derivatives

Bin Cheng; Yuki Hirokami; Yi Xian Li; Atsushi Kato; Yue Mei Jia; Chu Yi Yu

doi:10.1016/j.cclet.2017.06.016

Synthesis and glycosidase inhibition of C-7 modified casuarine derivatives

Bin Cheng, Yuki Hirokami, Yi Xian Li, Atsushi Kato, Yue Mei Jia, Chu Yi Yu^*

^*Corresponding author for this work

Hospital Pharmacy

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A series of C-7 modified analogues of casuarine have been synthesized from sugar-derived nitrone and assayed against various glycosidases. Introduction of C-7 aminomethyl or amide group led to sharp decrease of the inhibitory activities.

Original language	English
Pages (from-to)	1701-1704
Number of pages	4
Journal	Chinese Chemical Letters
Volume	28
Issue number	8
DOIs	https://doi.org/10.1016/j.cclet.2017.06.016
State	Published - 2017/08

Keywords

1,3-Dipolar cycloaddition
Ammonolysis
Glycosidase inhibitors
Nitrone
Polyhydroxylated pyrrolizidines

ASJC Scopus subject areas

General Chemistry

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10.1016/j.cclet.2017.06.016

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title = "Synthesis and glycosidase inhibition of C-7 modified casuarine derivatives",

abstract = "A series of C-7 modified analogues of casuarine have been synthesized from sugar-derived nitrone and assayed against various glycosidases. Introduction of C-7 aminomethyl or amide group led to sharp decrease of the inhibitory activities.",

keywords = "1,3-Dipolar cycloaddition, Ammonolysis, Glycosidase inhibitors, Nitrone, Polyhydroxylated pyrrolizidines",

author = "Bin Cheng and Yuki Hirokami and Li, {Yi Xian} and Atsushi Kato and Jia, {Yue Mei} and Yu, {Chu Yi}",

note = "Publisher Copyright: {\textcopyright} 2017",

year = "2017",

month = aug,

doi = "10.1016/j.cclet.2017.06.016",

language = "英語",

volume = "28",

pages = "1701--1704",

journal = "Chinese Chemical Letters",

issn = "1001-8417",

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T1 - Synthesis and glycosidase inhibition of C-7 modified casuarine derivatives

AU - Cheng, Bin

AU - Hirokami, Yuki

AU - Li, Yi Xian

AU - Kato, Atsushi

AU - Jia, Yue Mei

AU - Yu, Chu Yi

PY - 2017/8

Y1 - 2017/8

N2 - A series of C-7 modified analogues of casuarine have been synthesized from sugar-derived nitrone and assayed against various glycosidases. Introduction of C-7 aminomethyl or amide group led to sharp decrease of the inhibitory activities.

AB - A series of C-7 modified analogues of casuarine have been synthesized from sugar-derived nitrone and assayed against various glycosidases. Introduction of C-7 aminomethyl or amide group led to sharp decrease of the inhibitory activities.

KW - 1,3-Dipolar cycloaddition

KW - Ammonolysis

KW - Glycosidase inhibitors

KW - Nitrone

KW - Polyhydroxylated pyrrolizidines

UR - http://www.scopus.com/inward/record.url?scp=85021117196&partnerID=8YFLogxK

U2 - 10.1016/j.cclet.2017.06.016

DO - 10.1016/j.cclet.2017.06.016

M3 - 学術論文

AN - SCOPUS:85021117196

SN - 1001-8417

VL - 28

SP - 1701

EP - 1704

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 8

ER -

Synthesis and glycosidase inhibition of C-7 modified casuarine derivatives

Abstract

Keywords

ASJC Scopus subject areas

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